<i>Bauhinia pulchella</i>: chemical constituents, antioxidant and alpha-glucosidase inhibitory activities

Monteiro, Aurelio de Oliveira; Carvalho, Jarbas Lima de; Silva, Horlando Carlota da; Nascimento, Gerlan Oliveira do; Silva, Ana Maria Amaral; Trevisan, M.; Santiago, Gilvandete Maria Pinheiro

doi:10.1080/14786419.2021.1887176

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…[15,16] Plants of the Bauhinia genus exhibit various phytochemicals with antioxidant activities described in the literature, characterized by high levels of phenolic compounds and flavonoids. [17,18] Although the mechanisms behind the antioxidant activity of this species remain obscure, the antioxidant effects of Bauhinia ungulata essential oil (EOBU) have not been addressed. With this premise, work aims to trace the different bioactive compounds in EOBU collected during the rainy season in Boa Vista, Roraima -Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…[13,14] Studies have revealed that B. ungulata possesses antioxidant, antimicrobial, larvicidal, anti‐inflammatory, cytotoxic, antiproliferative, and antiacetylcholinesterase properties, as well as hypoglycemic effects [15,16] . Plants of the Bauhinia genus exhibit various phytochemicals with antioxidant activities described in the literature, characterized by high levels of phenolic compounds and flavonoids [17,18] …”

Section: Introductionmentioning

confidence: 99%

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In Vitro and In Silico Antioxidant Activity and Molecular Characterization of Bauhinia ungulata L. Essential Oil

Nunes de Andrade Medeiros,

Conrado Bezerra,

José da Silva

et al. 2024

Chemistry & Biodiversity

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Bauhinia ungulate is an antioxidant medicinal plant used in Brazil to lower glycemic index and alternative treatment for diabetes. Therefore, this study aimed to investigate the antioxidant effects of the essential oil of Bauhinia ungulata (EOBU) collected in Boa Vista, Roraima, Brazil, located in the Amazon region. Gas chromatography was used to characterize the components, and antioxidant assays such as DPPH, TAC, reducing power, Fe2+ chelation, and total phenols were performed. The major constituents were molecularly anchored with the human catalase (CAT) enzyme, and maltol was used as a positive control. Among the 25 revealed components, the main ones were α‐bisabolol (27.2%), β‐Caryophyllene (12.5%), Epi‐γ‐eudesmol (13.6%), α‐Humulene (4.5%), and Caryophyllene Oxide (4.3%). The EOBU showed a TAC value of 618.79 mg of ascorbic acid equivalent, free radical scavenging capacity (DPPH) around 43% and 65%, Fe2+ chelation capacity of 161 ± 6 and 126.7 ± 39.6, for 0.1 mg.mL‐1 and 0.5 mg.mL‐1, respectively. Also, 96.5% of total phenols. α‐bisabolol (‐5.7 ± 0.4 Kcal.mol‐1) and β‐caryophyllene (‐6.1 ± 0.5 Kcal.mol‐1) showed good interaction with CAT compared to Maltol (‐4.4 ± 0.4 Kcal.mol‐1). This study demonstrated that EOBU functions as a potent antioxidant, capable of scavenging free radicals and reducing oxidative stress damage.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro and In Silico Antioxidant Activity and Molecular Characterization of Bauhinia ungulata L. Essential Oil

Nunes de Andrade Medeiros,

Conrado Bezerra,

José da Silva

et al. 2024

Chemistry & Biodiversity

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“…Ivorian flora is abundant in medicinal plants. Previous phytochemical and biological studies on the plants of the genus Bauhinia revealed the presence of several classes of secondary metabolites including terpenoids, flavonoids and other phenolic compounds with various biological activities [5,6,7,8,9]. Among these plants, Bauhinia thonningii Schumach & Thonn, is employed in traditional medicine to treat various illnesses, including urinary tract infection [10].…”

Section: Introductionmentioning

confidence: 99%

Bauhinia thonningii Schumach & Thonn (Fabaceae): Phytochemical Screening and Evaluation of the Antibacterial Activity of Barks

Brice,

Axel,

Benson

2024

CSIJ

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The aim of this study was to identify the groups of chemical compounds present in the aqueous extract of B. thoninginii bark from Ivorian flora and to assess its antibacterial activity against multi-resistant strains of P. aeruginosa and A. baumannii. Phytochemical sorting was used to identify polyphenols, flavonoids, tannins, coumarins, alkaloids, terpenes and derivatives. The levels of polyphenols, flavonoids, flavone aglycones, anthocyanins and condensed tannins were respectively 0.748 ± 0.03, 0.091 ± 0.01, 0.0094 ± 0.03, 0.0359 ± 0.01 and 0.117 ± 0.02 mg EAG /g MS. Sensitivity tests showed that BT was ineffective against multi-resistant strains of P. aeruginosa and A. baumannii.

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“…Taraxerone, an active constituent of the traditional Chinese herb threadleaf white velvet , is a compound derived from its herbal extract. Notably, taraxerone has been shown to exhibit remarkable immunomodulatory, antiallergic, anti‐inflammatory, hypoglycemic, and other notable biological effects (Ahmed et al, 2010; Barboza et al, 2020; Chunhakant & Chaicharoenpong, 2019; Jayaraman & Variyar, 2021; Mawa et al, 2016; Monteiro et al, 2022; Sung et al, 2012). However, the effects and mechanisms of action of taraxerone on pulmonary fibrosis remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Taraxerone exerts antipulmonary fibrosis effect through Smad signaling pathway and antioxidant stress response in a Sirtuin1‐dependent manner

Chen,

Xie,

Tang

et al. 2024

Phytotherapy Research

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Idiopathic pulmonary fibrosis treatments are limited, often with severe side effects, highlighting the need for novel options. Taraxerone has diverse biomedical properties, but its mechanism remains unclear. This study investigates taraxerone's impact and the mechanisms involved in bleomycin‐induced pulmonary fibrosis in mice. After establishing a pulmonary fibrosis mouse model, taraxerone was intraperitoneally injected continuously for 14–28 days. The in vivo antifibrotic and antioxidative stress effects of taraxerone were assessed. In vitro, the influence of taraxerone on transforming growth factor‐β1‐induced myofibroblast transformation and oxidative stress was investigated. Subsequently, quantitative polymerase chain reaction screened the histone deacetylase and Sirtuin family, and taraxerone's effects on SIRT1 were assessed. After SIRT1 siRNA treatment, changes in myofibroblast transformation and antioxidant capacity in response to taraxerone were observed. Acetylation and phosphorylation levels of Smad3 were evaluated. We also examined the binding levels of SIRT1 with Pho‐Smad3 and Smad3, as well as the nuclear localization of Smad2/3. EX527 confirmed SIRT1's in vivo action in response to taraxerone. In vitro experiments suggested that taraxerone inhibited myofibroblast differentiation by activating SIRT1 and reducing oxidative stress. We also observed a new interaction between SIRT1 and the Smad complex. Taraxerone activates SIRT1, enabling it to bind directly to Smad3. This leads to reduced Smad complex phosphorylation and limited nuclear translocation. As a result, the transcription of fibrotic factors is reduced. In vivo validation confirms taraxerone's SIRT1‐mediated antifibrotic effectiveness. This suggests that targeting SIRT1‐mediated inhibition of myofibroblast differentiation could be a key strategy in taraxerone‐based therapy for pulmonary fibrosis.

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Bauhinia pulchella: chemical constituents, antioxidant and alpha-glucosidase inhibitory activities

Cited by 6 publications

References 27 publications

In Vitro and In Silico Antioxidant Activity and Molecular Characterization of Bauhinia ungulata L. Essential Oil

In Vitro and In Silico Antioxidant Activity and Molecular Characterization of Bauhinia ungulata L. Essential Oil

Bauhinia thonningii Schumach & Thonn (Fabaceae): Phytochemical Screening and Evaluation of the Antibacterial Activity of Barks

Taraxerone exerts antipulmonary fibrosis effect through Smad signaling pathway and antioxidant stress response in a Sirtuin1‐dependent manner

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