In vitro evaluation of physical and chemical parameters involved in aPDT of Aggregatibacter actinomycetemcomitans

Sousa, Gerdal Roberto de; Soares, Leandro O; Soares, Betânia Maria; Cruz, Rosana de Carvalho; Uliana, Paulo; Santiago, Thiago de Melo; Farias, Luiz M.; Magalhães, Paula Prazeres; Silveira, Lívio Barros; Lopes, Luciana Almeida; Mancini, Marília Wellichan; Huebner, Rudolf; Ferreira, Marta Araújo Tavares

doi:10.1007/s10103-021-03267-4

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Red/infrared diode laser was used as the light source for a-PDT with blue dye initially, and its antibacterial effect against Gram-negative periodontopathic bacteria, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, has been demonstrated in vitro. Additional studies using red/infrared LED light have been conducted to confirm their efficacy [38,39]. Commercially available laser devices specifically designed for a-PDT in dental treatment were released before LEDs, and most clinical studies have used diode lasers.…”

Section: Red Light/infrared Lightmentioning

confidence: 99%

Application of Different Wavelengths of LED Lights in Antimicrobial Photodynamic Therapy for the Treatment of Periodontal Disease

Takeuchi,

Aoki,

Hiratsuka

et al. 2023

Antibiotics

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Therapeutic light has been increasingly used in clinical dentistry for surgical ablation, disinfection, bio-stimulation, reduction in inflammation, and promotion of wound healing. Photodynamic therapy (PDT), a type of phototherapy, has been used to selectively destroy tumor cells. Antimicrobial PDT (a-PDT) is used to inactivate causative bacteria in infectious oral diseases, such as periodontitis. Several studies have reported that this minimally invasive technique has favorable therapeutic outcomes with a low probability of adverse effects. PDT is based on the photochemical reaction between light, a photosensitizer, and oxygen, which affects its efficacy. Low-power lasers have been predominantly used in phototherapy for periodontal treatments, while light-emitting diodes (LEDs) have received considerable attention as a novel light source in recent years. LEDs can emit broad wavelengths of light, from infrared to ultraviolet, and the lower directivity of LED light appears to be suitable for plaque control over large and complex surfaces. In addition, LED devices are small, lightweight, and less expensive than lasers. Although limited evidence exists on LED-based a-PDT for periodontitis, a-PDT using red or blue LED light could be effective in attenuating bacteria associated with periodontal diseases. LEDs have the potential to provide a new direction for light therapy in periodontics.

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Section: Red Light/infrared Lightmentioning

confidence: 99%