The role of the light source in antimicrobial photodynamic therapy

Piksa, Marta; Lian, Cheng; Samuel, Imogen C; Pawlik, Krzysztof; Samuel, Ifor D. W.; Matczyszyn, Katarzyna

doi:10.1039/d0cs01051k

Cited by 77 publications

(50 citation statements)

References 445 publications

(307 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…356−358 Selective and efficient PDT can also be realized by precisely manipulating the light irradiation area, which is an effective way to minimize side effects to healthy tissues. 359 Besides, PDT exhibits several other merits such as noninvasiveness, few side effects, negligible drug resistance and low systemic toxicity, all of which has motivated scientists to work on PDT as a therapeutic modality for disease treatment. 360,361 As one of the key elements in PDT, various PSs such as porphyrin, chlorin, phthalocyanine, squaraine, BODIPY derivatives, and transition metal complexes have been explored so far to date.…”

Section: Combat Diseases: Cancer Theranostics and Bacterial Eliminationmentioning

confidence: 99%

Aggregation-Induced Emission (AIE), Life and Health

Wang

Alam

et al. 2023

ACS Nano

View full text Add to dashboard Cite

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

show abstract

Section: Combat Diseases: Cancer Theranostics and Bacterial Eliminationmentioning

confidence: 99%

Aggregation-Induced Emission (AIE), Life and Health

Wang

Alam

et al. 2023

ACS Nano

View full text Add to dashboard Cite

show abstract

“…This NIR light is weakly absorbed and scattered by tissues and penetrates deeper into biological samples than the shorter wavelengths used for excitation of fluorescence through onephoton absorption. 27,28 In most cases, the TPEFM imaging of biological systems is carried out not through autofluorescence (which is usually weak) but with the use of fluorescent markers. The design of new candidates for such an application needs to take into account physical, chemical, and biological aspects of the experiments such as the presence of effective TPA in the first biological-window wavelength range, high fluorescence quantum yield, and compatibility with aqueous media.…”

Section: Introductionmentioning

confidence: 99%

“…Typically, irradiation in the near-infrared (NIR) region (in the first biological window) is used. This NIR light is weakly absorbed and scattered by tissues and penetrates deeper into biological samples than the shorter wavelengths used for excitation of fluorescence through one-photon absorption. , …”

Section: Introductionmentioning

confidence: 99%

Strongly Emitting Folic Acid-Derived Carbon Nanodots for One- and Two-Photon Imaging of Lyotropic Myelin Figures

Benkowska-Biernacka

Mucha

Firlej

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Non-invasive imaging of morphological changes in biologically relevant lipidic mesophases is essential for the understanding of membrane-mediated processes. However, its methodological aspects need to be further explored, with particular attention paid to the design of new excellent fluorescent probes. Here, we have demonstrated that bright and biocompatible folic acid-derived carbon nanodots (FA CNDs) may be successfully applied as fluorescent markers in one- and two-photon imaging of bioinspired myelin figures (MFs). Structural and optical properties of these new FA CNDs were first extensively characterized; they revealed remarkable fluorescence performance in linear and non-linear excitation regimes, justifying further applications. Then, confocal fluorescence microscopy and two-photon excited fluorescence microscopy were used to investigate a three-dimensional distribution of FA CNDs within the phospholipid-based MFs. Our results showed that FA CNDs are effective markers for imaging various forms and parts of multilamellar microstructures.

show abstract

“…4,5 One possibility is the photodynamic inhibition or photodynamic inactivation (PDI) of pathogenic bacteria, in which the oxidative stress following irradiation with visible light leads to microbial death. 6 PDI operates through the synergistic action of molecular oxygen, naturally present in cells, appropriately designed nontoxic photosensitizers (PS) and light. Upon light excitation, the PS ends up in a triplet state that can transfer energy/ electrons to molecular oxygen.…”

Section: Introductionmentioning

confidence: 99%