High protein diet leads to prediabetes remission and positive changes in incretins and cardiovascular risk factors

Reply to Landry et al. Findings from Diet Comparison Difficult to Interpret in the Absence of Adherence Assessment. Comment on “Tricò et al. Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals. Nutrients 2021, 13, 1345”

“…It is not surprising therefore-and perhaps a further clue of the good adherence to the diet-that volunteers randomized to the low-carbohydrate diet lost more weight than those following a balanced Mediterranean diet. Whether the higher efficacy of the low-carbohydrate/high-protein diet is driven by the peculiar properties of proteins [5][6][7][8][9] or could be partly attributed to greater engagement and adherence of participants, as suggested by the Authors [1], cannot be established from our data. However, a different engagement between the two study groups seems unlikely given that all participants were extremely motivated to achieve a minimum weight loss of 5%, regardless of the type of diet, as strictly required to qualify for future metabolic surgery.…”

Clinical Evidence of Low-Carbohydrate Diets against Obesity and Diabetes Mellitus

“…In comparison with typical dietary interventions, a low-carbohydrate/high-protein diet exhibits better efficiency in decreasing body mass in a brief time period [ 46 ].This finding was ascribed to the satiating effects of protein and its effect on inhibiting hunger [ 47 ], and to the rise in thermogenesis due to food ingestion [ 48 ] compared to carbohydrates and fat. Particularly, in people affected by obesity eligible for bariatric surgery, an LCD is suggested as a reasonable way to achieve a 5–10% body mass reduction in the preoperative period, which facilitates surgery and decreases the probability of adverse events [ 42 ].…”

In vitro comparison of whey protein isolate and hydrolysate for their effect on glucose homeostasis markers

“…The key to fighting diabetes and metabolic syndrome is a change in diet, including a reduction in saturated fat and cholesterol and an increase in the consumption of low-fat dairy products, vegetables, and cereals. A high-protein diet has already shown positive results on satiety and the production of hypoglycaemic hormones such as insulin (32)(33)(34). In addition, a high-protein diet may yield better results than an isoenergetic diet of fat and carbohydrates (35).…”