Evolution of SARS-CoV-2: A prediction on the lineages and vaccine effectiveness

Choudhary, Priyanka; Choudhary, Om Prakash; Singh, Indraj

doi:10.1016/j.tmaid.2021.101983

Cited by 5 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adopting mass vaccination against COVID-19 vaccine has become a key measure for countries to fight against the epidemic 43 . In addition, the development and approval of intra-nasal vaccines against COVID-19 have turned out to be a global game changer 44 .…”

Section: Discussionmentioning

confidence: 99%

Healthcare workers’ knowledge and risk perception regarding the first wave of COVID-19 in Khyber Pakhtunkhwa, Pakistan: an online cross-sectional survey

Ali,

Hassan,

Rahat Ullah

et al. 2024

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Background: Increased COVID-19 transmission among the populace may be caused by HCWs who lack knowledge, awareness, and good preventive practices. Additionally, it may cause elevated stress levels, anxiety, poor medical judgement, and situational overestimation. Objectives: The present survey aimed to assess knowledge and risk perception regarding COVID-19 among Health Care Workers (HCWs) in Khyber Pakhtunkhwa (KP), Pakistan. Methodology: A web-based online, pre-tested questionnaire comprising 26 items was circulated via social media in April 2020 amongst HCWs in major tertiary care facilities in KP. Results: The study’s results, revealing both the commendable knowledge levels among Health Care Workers (HCWs) about COVID-19 and their heightened risk perception, highlight the critical need for targeted interventions to address the potential impact on self-protective behaviour and mental health within this vital workforce. This insight is important for designing strategies that not only enhance HCWs’ well-being but also ensure the continued effectiveness of healthcare delivery during pandemics. The percentage mean score (PMS) of COVID-19 knowledge was 85.14±10.82. Male HCWs and those with an age ≥32 years demonstrated a higher knowledge score (85.62±11.08; P=0.032 & 87.59±7.33, P=0.021 respectively). About 76% of HCWs feared contracting COVID-19. Nearly 82% of respondents were mentally preoccupied with the pandemic and also terrified of it. ‘Of these, 81% were nurses, 87% had a job experience of 6-8 years and 54.45% were frontline workers. Feelings of panic and concern about the pandemic were found to be more in HCWs who were physicians above the age of 32, and who had 3-5 years of work experience. HCWs’ overall risk perception was found to be significantly different between males (7.04±2.26) and females (8.01±1.97), job experience of 6-10 years (8.04±177) with 3-5 years and ≤2 years job experience (7.18±2.43,6.93±2.22) respectively and between frontline HCWs (7.50±2.10) and non-frontline HCWs (6.84±2.40). Conclusion: HCWs demonstrated good knowledge about COVID-19. As the risk perception of COVID-19 among HCWs is high, it can raise concerns about their self-protective behaviour, and mental health. These issues need to be addressed.

show abstract

Section: Discussionmentioning

confidence: 99%

Healthcare workers’ knowledge and risk perception regarding the first wave of COVID-19 in Khyber Pakhtunkhwa, Pakistan: an online cross-sectional survey

Ali,

Hassan,

Rahat Ullah

et al. 2024

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

show abstract

“…As of March 2021, >132 million COVID‐19 cases with 2.86 million deaths have been reported worldwide 3 . New variants have alarming implications on the efficiency of current vaccines, 41 signaling a pandemic that is far from over. Heath care personnel will continue to remain on the frontlines and therefore require respirator use.…”

Section: Discussionmentioning

confidence: 99%

N95 vs Half‐face Respirator Wear in Surgical Trainees: Physiologic and Psychological Effects of Prolonged Use

et al. 2021

View full text Add to dashboard Cite

Objectives As specialists of the upper airway, otolaryngologists are at high risk for COVID-19 transmission. N95 and half-face respirator (HFR) masks are commonly worn, each with advantages in functionality and comfort. In this study, physiologic and psychological parameters of prolonged N95 vs HFR wear were compared. Study Design Prospective crossover cohort study. Setting Single academic tertiary care hospital. Methods A prospective crossover cohort study was performed. Healthy otolaryngology trainees and medical students (N = 23) participated and wore N95 and HFR masks continuously for 3 hours each on separate days. Various measures were analyzed: vitals, spirometry variables, scores on the State-Trait Anxiety Inventory and HIT-6 (Headache Impact Test–6), distress, and “difficulty being understood.” Results The average age was 26.3 years (SD, 3.42). There were no significant differences in vital signs and spirometry variables between N95 and HFR wear. N95 wear was associated with decreases in oxygen saturation of approximately 1.09% more than with HFRs (95% CI, 0.105-2.077). State-Trait Anxiety Inventory scores increased more with HFR wear when compared with mean changes with N95 wear (95% CI, 1.350-8.741). There were no significant differences in HIT-6 scores or distress levels between masks. The proportions of participants reporting difficulty being understood was significantly higher with HFRs. Conclusions Oxygen saturation decreases with prolonged N95 wear, but anxiety and difficulty being understood are greater with HFR wear. Although HFRs have less resistance to gas exchange, N95 respirators may produce less anxiety and distress in clinical situations. Further studies are warranted to evaluate the clinical significance of these differences. Level of Evidence 2.

show abstract

“…Due to the limited understanding of the COVID-19 transmission and infectivity up to now, there are still no effective mitigation measures 6 . Despite of considerable efforts in vaccine development 7 – 10 , prevention 11 – 14 , and advancements in digital health 15 , 16 , the COVID-19 pandemic has a significant impact on healthcare systems and vulnerable patients, especially those with malignant brain tumours 4 , 17 . Glioblastoma (GBM) is the most common malignant primary intracranial lesion, accounting for nearly half of all primary malignant central nervous system tumours.…”

Section: Introductionmentioning

confidence: 99%

Glioblastoma patients’ survival and its relevant risk factors during the pre-COVID-19 and post-COVID-19 pandemic: real-world cohort study in the USA and China

Qin,

Li,

Zheng

et al. 2024

International Journal of Surgery

View full text Add to dashboard Cite

Background: Although the coronavirus disease 2019 (COVID-19) pandemic has exerted potential impact on patients with glioblastomas (GBMs), it remains unclear whether the survival and its related risk factors of GBM patients would be altered or not during the period spanning from pre- to post- COVID-19 pandemic era. This study aimed to clarify the important issues above. Methods: Two observational cohorts were utilized, including the nationwide American cohort from the Surveillance, Epidemiology, and End-Results (SEER) and the Chinese glioblastoma cohort (CGC) at our institution during 2018-2020. Demographics, tumor features, treatment regimens and clinical outcomes were collected. Cox regression model, competing risk model, and subgroup and sensitivity analysis were used to dynamically estimate the survival and its relevant risk factors over different diagnosis years from the pre- (2018 and 2019) to post-COVID-19 (2020) pandemic. Causal mediation analysis was further adopted to explore the potential relationship between risk factors and mortality. Results: This study included 11321 GBM cases in SEER and 226 GBM patients in CGC, respectively. Instead of the diagnostic years of 2018-2020, the prognostic risk factors, such as advanced age, bilateral tumor and absence of comprehensive therapy (surgery combined with chemoradiotherapy), were identified to persistently affect GBM survival independently during the period from 2018 to 2020 in the SEER cohort (all P < 0.05). In CGC, lack of comprehensive therapy for GBM patients were restated as survival risk factors during the same timeframe. Causal mediation analysis showed that the effect of comprehensive therapy on all-cause mortality played a determinant role (direct effect value -0.227, 95% confidence interval -0.248 to -0.207), which was partially mediated by age (9.11%) rather than tumor laterality. Conclusions: As the timeframe shifted from pre- to post-COVID-19 pandemic, survival of GBM patients remained stable, yet advanced age, bilateral tumors, and passive treatment continuingly impacted GBM survival. It is necessary to optimize the comprehensive treatment for GBM patients even in the post-pandemic era.

show abstract

Evolution of SARS-CoV-2: A prediction on the lineages and vaccine effectiveness

Cited by 5 publications

References 4 publications

Healthcare workers’ knowledge and risk perception regarding the first wave of COVID-19 in Khyber Pakhtunkhwa, Pakistan: an online cross-sectional survey

Healthcare workers’ knowledge and risk perception regarding the first wave of COVID-19 in Khyber Pakhtunkhwa, Pakistan: an online cross-sectional survey

N95 vs Half‐face Respirator Wear in Surgical Trainees: Physiologic and Psychological Effects of Prolonged Use

Glioblastoma patients’ survival and its relevant risk factors during the pre-COVID-19 and post-COVID-19 pandemic: real-world cohort study in the USA and China

Contact Info

Product

Resources

About