Co-administration of zinc phthalocyanine and quercetin via hybrid nanoparticles for augmented photodynamic therapy

Thakur, Neeraj; Mandal, Narattam; Patel, Gopal; Kirar, Seema; Reddy, Yeddula Nikhileshwar; Kushwah, Varun; Bhaumik, Jayeeta; Banerjee, Uttam Chand

doi:10.1016/j.nano.2021.102368

Cited by 30 publications

(35 citation statements)

References 56 publications

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“…The synthesized nanoparticle was tested both in vitro and in vivo. In vitro cytotoxic study shows increased cell death against MCF-7 cells, and an increased PDT antitumor effect in an in vivo study (Sprague Dawley rats) [100].…”

Section: Microemulsion Polymerization Methods ~170 and 220 Nm Hpphmentioning

confidence: 93%

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Kumar

Abrahamse

2021

Pharmaceutics

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In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

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Section: Microemulsion Polymerization Methods ~170 and 220 Nm Hpphmentioning

confidence: 93%

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Kumar

Abrahamse

2021

Pharmaceutics

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“…In this respect, natural polysaccharides such as hyaluronic acid (HA) [ 102 , 103 , 104 , 105 ], chitosan [ 102 , 106 , 107 , 108 ], chitin, heparin [ 95 , 99 , 100 ], and fucoidan [ 84 ] have been utilized as potential photosensitizer carriers due to their biocompatibility and biodegradability. In addition, not only polymers but also hydrophobic small molecule anticancer drugs (such as doxorubicin [ 96 ], docetaxel [ 97 , 107 , 109 , 110 ], paclitaxel [ 85 , 93 , 103 , 111 , 112 ], camptothecin, and quercetin [ 113 , 114 ]) can be grafted onto PS.…”

Section: Nanotechnology For Enhanced Photodynamic Therapymentioning

confidence: 99%

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

Kim

Lee

2022

Biomedicines

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The current treatment for malignant brain tumors includes surgical resection, radiotherapy, and chemotherapy. Nevertheless, the survival rate for patients with glioblastoma multiforme (GBM) with a high grade of malignancy is less than one year. From a clinical point of view, effective treatment of GBM is limited by several challenges. First, the anatomical complexity of the brain influences the extent of resection because a fine balance must be struck between maximal removal of malignant tissue and minimal surgical risk. Second, the central nervous system has a distinct microenvironment that is protected by the blood–brain barrier, restricting systemically delivered drugs from accessing the brain. Additionally, GBM is characterized by high intra-tumor and inter-tumor heterogeneity at cellular and histological levels. This peculiarity of GBM-constituent tissues induces different responses to therapeutic agents, leading to failure of targeted therapies. Unlike surgical resection and radiotherapy, photodynamic therapy (PDT) can treat micro-invasive areas while protecting sensitive brain regions. PDT involves photoactivation of photosensitizers (PSs) that are selectively incorporated into tumor cells. Photo-irradiation activates the PS by transfer of energy, resulting in production of reactive oxygen species to induce cell death. Clinical outcomes of PDT-treated GBM can be advanced in terms of nanomedicine. This review discusses clinical PDT applications of nanomedicine for the treatment of GBM.

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“…One such combination of medicine includes the use of phytochemicals. A study by Thakur and colleagues combined the PS, zinc phthalocyanine, with quercetin to improve the cancer-killing effects [ 19 ]. A study that combined quercetin and PDT with an aluminum phthalocyanine tetrasulfonate PS on human larynx carcinoma cells resulted in cell cytotoxicity [ 16 ].…”

Section: Photodynamic Therapymentioning

confidence: 99%

“…These include the treatment of cancers, such as skin, breast, prostate, oral, colon, etc., with positive therapeutic outcomes [ 14 , 15 ]. Phytochemicals are also used in photodynamic therapy for cancer [ 16 , 17 , 18 , 19 ]. These phytochemicals are used as photosensitizers and include riboflavin, punicalagin, and quercetin [ 16 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Efficacy of Punica granatum and Its Bioactive Constituents with Special Reference to Photodynamic Therapy

Fakudze

Aniogo

George

et al. 2022

Plants

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Punica granatum (P. granatum) is a fruit-bearing tree from the Punicaceae family, indigenous to Iran. This plant has healing qualities that have drawn the interest of the medical community as an alternative treatment for malignancies and non-malignancies. Its healing quality is due to the phytochemicals present in the plant. These include ellagic acid, punicic acid, phenols, and flavonoids. In traditional medicine, P. granatum has been used in treating diseases such as dysentery, bleeding disorders, leprosy, and burns. This review explores the effects of the phytochemical constituents of P. granatum on photodynamic therapy for cancer, chronic inflammation, osteoarthritis, and viral infections. Its antioxidant and antitumor effects play a role in reduced free radical damage and cancer cell proliferation. It was concluded that P. granatum has been used for many disease conditions for a better therapeutic outcome. This paper will give visibility to more studies and expand the knowledge on the potential use of P. granatum in photodynamic cancer treatment.

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Co-administration of zinc phthalocyanine and quercetin via hybrid nanoparticles for augmented photodynamic therapy

Cited by 30 publications

References 56 publications

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors

The Therapeutic Efficacy of Punica granatum and Its Bioactive Constituents with Special Reference to Photodynamic Therapy

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