Two new 2,5-diketopiperazine derivatives from mangrove-derived endophytic fungus <i>Nigrospora camelliae-sinensis</i> S30

Huang, Dan-Yu; Nong, Xu‐Hua; Zhang, Yuqin; Xu, Wei; Sun, Long-Yu; Zhang, Tao; Chen, Guang‐Ying; Han, Chang‐Ri

doi:10.1080/14786419.2021.1878168

Cited by 10 publications

(4 citation statements)

References 29 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CHP reportedly accumulates in the CNS regardless of its low entry rate owing to its long half-life and marked resistance to enzymatic degradation [ 63 ]. Therefore, compound 8 could maintain a precise CNS concentration owing to its high stability against enzymatic hydrolysis [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…2,5-Diketopiperazines (2,5-DKPs), also known as cyclic dipeptides [ 27 ], are found to occur in diverse natural products [ 28 ] and demonstrate attractive bioactivities, including antitumor, neuroprotective, anti-inflammatory, and antibiotic activities [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Moreover, these compounds were found to possess high stability against proteolysis as well as superior intestinal absorption conferred by their unique heterocyclic structure [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Effect of Cyclo-(L-Pro-L-Phe) Isolated from the Jellyfish-Derived Fungus Aspergillus flavus

Wang

Kim

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

Peroxisome proliferator-activated receptor (PPAR) expression has been implicated in pathological states such as cancer, inflammation, diabetes, and neurodegeneration. We isolated natural PPAR agonists—eight 2,5-diketopiperazines—from the jellyfish-derived fungus Aspergillus flavus. Cyclo-(L-Pro-L-Phe) was the most potent PPAR-γ activator among the eight 2,5-DKPs identified. Cyclo-(L-Pro-L-Phe) activated PPAR-γ in Ac2F rat liver cells and SH-SY5Y human neuroblastoma cells. The neuroprotective effect of this partial PPAR-γ agonist was examined using the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, lactate dehydrogenase release, and the Hoechst 33342 staining assay in SH-SY5Y cells. Our findings revealed that cyclo-(L-Pro-L-Phe) reduced hydrogen peroxide-induced apoptosis as well as the generation of reactive oxygen species. Rhodamine 123 staining and western blotting revealed that cyclo-(L-Pro-L-Phe) prevented the loss of mitochondrial membrane potential and inhibited the activation of mitochondria-related apoptotic proteins, such as caspase 3 and poly (ADP-ribose) polymerase. Moreover, cyclo-(L-Pro-L-Phe) inhibited the activation and translocation of nuclear factor-kappa B. Thus, the partial PPAR-γ agonist cyclo-(L-Pro-L-Phe) demonstrated potential neuroprotective activity against oxidative stress-induced neurodegeneration in SH-SY5Y cells.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Cyclo-(L-Pro-L-Phe) Isolated from the Jellyfish-Derived Fungus Aspergillus flavus

Wang

Kim

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…299 Sediment-derived Nigrospora camelliae-sinensis yielded two simple diketopiperazines nigrosporaamides A 837 and B 838 . 300 A thiodiketopiperazine, adametizine C 839 and alkane derivatives 840 – 844 were reported from sediment-derived Penicillium ludwigii . Adametizine C showed weak anti-inflammatory activity.…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

Carroll,

Copp,

Grkovic

et al. 2024

Nat. Prod. Rep.

View full text Add to dashboard Cite

show abstract

“…Specifically, Nigrospora oryzae and Nigrospora sphaerica have predominantly been isolated from marine organisms such as corals [ 12 ], mangroves [ 13–15 ], macroalgae [ 16–19 ], sea fans [ 19 , 20 ], and sponges [ 21 , 22 ]. Furthermore, Nigrospora camelliae-sinensis has been isolated from a mangrove [ 23 ], and Nigrospora aurantiaca has been found in sponges [ 24 ]. Most of these studies aimed at discovering bioactive compounds derived from Nigrospora rather than exploring its diversity or ecological interactions.…”

Section: Introductionmentioning

confidence: 99%

Diversity of Nigrospora ( Xylariales , Apiosporaceae ) Species Identified in Korean Macroalgae Including Five Unrecorded Species

Lee,

Kim,

Perera

et al. 2023

Mycobiology

View full text Add to dashboard Cite

Nigrospora ( Xylariales , Apiosporaceae ) consists of species of terrestrial plant endophytes and pathogens. Nigrospora has also been reported in marine environments such as mangroves, sea fans, and macroalgae. However, limited research has been conducted on Nigrospora associated with macroalgae. Here, we isolated Nigrospora species from three types of algae (brown, green, and red algae) from Korean islands (Chuja, Jeju, and Ulleung) based on phylogenetic analyses of multigenetic markers: the internal transcribed spacers (ITS), beta-tubulin ( BenA ), and translation elongation factor 1 ( TEF1-α ). A total of 17 Nigrospora strains were isolated from macroalgae and identified as nine distinct species. The majority of Nigrospora species (seven) were found on brown algae, followed by red algae (three), and then green algae (two). To our understanding, this study represents the first account of N. cooperae , N. covidalis , N. guilinensis , N. lacticolonia , N. osmanthi , N. pyriformis , and N. rubi occurring in marine environments. Additionally, this study provides the first report of the occurrence of N. cooperae , N. covidalis , N. guilinensis , N. lacticolonia , and N. osmanthi in South Korea. This study will provide valuable insights for future research exploring the functions of fungi in macroalgal communities.

show abstract

Two new 2,5-diketopiperazine derivatives from mangrove-derived endophytic fungus Nigrospora camelliae-sinensis S30

Cited by 10 publications

References 29 publications

Neuroprotective Effect of Cyclo-(L-Pro-L-Phe) Isolated from the Jellyfish-Derived Fungus Aspergillus flavus

Neuroprotective Effect of Cyclo-(L-Pro-L-Phe) Isolated from the Jellyfish-Derived Fungus Aspergillus flavus

Marine natural products

Diversity of Nigrospora ( Xylariales , Apiosporaceae ) Species Identified in Korean Macroalgae Including Five Unrecorded Species

Contact Info

Product

Resources

About