Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies

Emma, Maria Rita; Augello, Giuseppa; Stefano, Vita Di; Azzolina, Antonina; Giannitrapani, Lydia; Montalto, Giuseppe; Cervello, Melchiorre; Cusimano, Antonella

doi:10.3390/ijms22031234

Cited by 59 publications

(53 citation statements)

References 131 publications

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“…Thus, the bitterness of many of this compounds has been considered to be a deterrent for herbivores [29]. The potential protective role exhibited by secoiridoids from Olea europaea L. for the prevention and treatment of cancers of inflammatory and reactive oxygen species (ROS)-mediated diseases was recently described in the literature [30,31]. Thus, the observed increase of secoiridoids content for the untreated infected cultivar could be also taken into account for possible biotechnological use in pharma industry.…”

Section: Cultivar-related Treatment Effects For Naturally Infected Leccino Cellina DI Nardò and Ogliarola Salentina Over The Two Leaf Sammentioning

confidence: 99%

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Girelli

Coco

Angilè

et al. 2021

Plants

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Xylella fastidiosa subsp. pauca, is a bacterial phytopathogen associated with the “olive quick decline syndrome” (OQDS) causing severe economic losses to olive groves in Salento area (Apulia, Italy). In a previous work, we analyzed by 1H-NMR the metabolic pattern of naturally infected Ogliarola salentina and Cellina di Nardò susceptible cultivars untreated and treated with a zinc-copper citric acid biocomplex and we observed the treatment related variation of the disease biomarker quinic acid. In this study, we focused also on the Leccino cultivar, known to exhibit tolerance to the disease progression. The 1H-NMR-based metabolomic approach was applied with the aim to characterize the overall metabolism of tolerant Leccino in comparison with the susceptible cultivars Ogliarola salentina and Cellina di Nardò under periodic mid-term treatment. In particular, we studied the leaf extract molecular patterns of naturally infected trees untreated and treated with the biocomplex. The metabolic Leccino profiles were analyzed for the first time and compared with those exhibited by the susceptible Cellina di Nardò and Ogliarola salentina cultivars. The study highlighted a specificity in the metabolic response of the tolerant Leccino compared to susceptible cultivars. These differences provide useful information to describe the defensive mechanisms underlying the change of metabolites as a response to the infection, and the occurrence of different levels of disease, season and treatment effects for olive cultivars.

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Section: Cultivar-related Treatment Effects For Naturally Infected Leccino Cellina DI Nardò and Ogliarola Salentina Over The Two Leaf Sammentioning

confidence: 99%

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Girelli

Coco

Angilè

et al. 2021

Plants

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“…Secoiridoids include several bioactive compounds found expressed in all species of Oleaceae plants. The composition of bioactive molecules in the leaves depends on plant variety and season harvesting [1][2][3][4][5][6]. In the leaves, oleuropein is the most abundant secoiridoid, having welldocumented health effects.…”

Section: Introductionmentioning

confidence: 99%

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Centrone

Ranieri

Mise

et al. 2021

FFHD

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In the last few years, the production of olive oil has incredibly increased due to its beneficial properties on human health. On the other hand, the amount of waste and by-products derived from the olive oil industry has increased as well, prompting the development of new fields of research aiming to reduce disposal costs and valorize bioactive compounds from the viewpoint of the green economy. Interestingly, olive oil and by-products contain numerous molecules, including phenols, exhibiting pleiotropic effects in both in vitro and in vivo studies. This review aims to describe the more recent studies focusing to identify and describe the potential roles and the new applications of extracts isolated from wastes and by-products or specific compounds, such as hydroxytyrosol (HT) and oleuropein. Extracts or bioactive molecules from olive oil and by-products have been proposed as a food additive, to produce biofuel, for animal feeding, and to create new matrices in bioremediation protocols. Moreover, bio-compounds have been described to have numerous beneficial effects on human health as they reduce the risk of developing certain chronic diseases. Despite the already published studies, more research is necessary to valorize bioactive compounds in olive oil and by-products, as well as their potential use to improve human health and green applications in different industrial processes. Keywords: extra virgin olive oil, by-products, olive leaf extract, bioactive compounds, human health, and industrial application

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“…The anti-inflammatory effect of turmeric and extra virgin olive oil provoked interest in several scientific research and has been discovered to have antioxidant and anti-inflammatory properties and many other diet's health benefits. Each can alter the human immune system by influencing the release of interleukins involved in immunological defense [17,18,19].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice

Attiyah

Mohammed

2021

JPRI

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Background: Anti-Inflammatory properties of turmeric and extra virgin olive oil have numerous health benefits. They exert and promote anti-inflammatory actions, moreover, each gives benefits that go beyond reducing inflammation. Objective: The aim of our study is to evaluate and compare the immunomodulatory effect of each turmeric and extra virgin olive oil (EVOO) alone or in combination. Methods: We demonstrated the serum level of pro-inflammatory cytokines IL-6 and IL-10 in healthy male Swiss albino mice (C57BL/6 strain) after oral intake of curcumin and extra virgin olive oil for six weeks by ELISA assay. Results: Our results showed that dietary intake of turmeric and EVOO had a reducing effect on serum IL-6 level and could increase the production of IL-10 level significantly. Inflammatory responses of turmeric and EVOO combination appear to be more effective on health by inhibition of IL 6 and induce IL 10 production. Conclusion: Anti-inflammatory effect of turmeric and EVOO can play an important role in modulating the level of IL 6 and IL-10. Moreover, co-administration of them having a greater anti-inflammatory effect.

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Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies

Cited by 59 publications

References 131 publications

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Olive Cultivars Susceptible or Tolerant to Xylella fastidiosa Subsp. pauca Exhibit Mid-Term Different Metabolomes upon Natural Infection or a Curative Treatment

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Effectiveness of Turmeric and Extra Virgin Olive Oil in the Management of IL 6 and IL 10 in Healthy Mice

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