Quantitative Assessment of Copper(II) in Wilson’s Disease Based on Photoacoustic Imaging and Ratiometric Surface-Enhanced Raman Scattering

Feng, Hongjuan; Fu, Qinrui; Du, Wei; Zhu, Rong; Xia, Ge; Wang, Chenlu; Li, Qingqing; Su, Lichao; Yang, Huanghao; Song, Jibin

doi:10.1021/acsnano.0c10407

Cited by 62 publications

(43 citation statements)

References 56 publications

(100 reference statements)

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“…First, the AuNNPs were synthesized according to our previous report. [ 15 ] The 17 nm AuNPs were first prepared referring to the well‐established sodium citrate reduction method and used as the seed (Figure S1, Supporting Information). Then, the AgNO 3 solution was added to form AuNPs@Ag through ascorbic acid reduction and the AuNPs@Ag were finally converted to AuNNPs by adding HAuCl 4 due to the oxidization and corrosion.…”

Section: Resultsmentioning

confidence: 99%

Stimuli‐Responsive Hybrid Vesicle for Tumor Dual‐Model NIR‐II Photoacoustic and Fluorescence Imaging and Precise Radiotherapy

Zhang

Wang

et al. 2022

Advanced Optical Materials

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Bioimaging guided‐radiotherapy is widely investigated as one of the mainstream cancer theranostic strategies for precision medicine. Nevertheless, background noise with “always‐on” imaging signal and inadequate tumor enrichment restrict disease diagnosis and therapy. Here, a nanogapped gold nanoparticles (AuNNPs)–silver sulfide (Ag2S) vesicle (Ve) is designed as a “biological switch” through the self‐assembly of pH‐responsive polymer thiolated polystyrene‐co‐poly(4‐vinylpyridine) grafted AuNNPs and Ag2S quantum dots (QDs). The AuNNPs–Ag2S Ve exhibits quenched NIR‐II fluorescence (FL) and enhanced photoacoustic signals initially, which can be specifically activated by an acidic environment to release Ag2S QDs and “turn on” NIR‐II FL signal in the second near‐infrared (NIR‐II, 950–1700 nm) window. Besides, the strategy of disease‐located NIR‐II imaging guided cancer therapy can remarkably enhance the therapeutic efficacy of radiotherapy, as well as minimize side effects. Such an intelligent nanoplatform with the ability of stimulus activated NIR‐II imaging guided radiotherapy shows great promise to precision biomedicine in the future.

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Section: Resultsmentioning

confidence: 99%

Stimuli‐Responsive Hybrid Vesicle for Tumor Dual‐Model NIR‐II Photoacoustic and Fluorescence Imaging and Precise Radiotherapy

Zhang

Wang

et al. 2022

Advanced Optical Materials

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“…has been widely used in various fields such as chemical and biological analysis, 2,3 medical diagnosis, 4,5 environmental analysis, 6,7 food safety, 8,9 and artwork restoration. 10 At present, the widely accepted SERS enhancement mechanism includes the electromagnetic enhancement mechanism (EM) and the chemical enhancement mechanism (CM).…”

Section: Erjin Zhangmentioning

confidence: 99%

“…1 As a powerful spectroscopic technique, SERS achieves ultratrace detection by amplifying the Raman signal of molecules and possesses the advantages of high sensitivity, fingerprint specificity, and non-destructive detection. SERS has been widely used in various fields such as chemical and biological analysis, 2,3 medical diagnosis, 4,5 environmental analysis, 6,7 food safety, 8,9 and artwork restoration. 10 At present, the widely accepted SERS enhancement mechanism includes the electromagnetic enhancement mechanism (EM) and the chemical enhancement mechanism (CM).…”

Section: Introductionmentioning

confidence: 99%

Semiconductor-based surface enhanced Raman scattering (SERS): from active materials to performance improvement

Wang

Zhang

Shi

et al. 2022

Analyst

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“…[37] In order to prepare AuNNPs, 13 nm AuNPs were first synthesized as the nanocore, followed by surface growing a silver (Ag) and Au nanoshell, and finally using the Ag etching method to obtain AuNNPs. [39] The AuNNPs were grafted with hydrophilic azido and thiolated polyethylene glycol (N 3 -PEG-SH, MW = 400 Da) through a covalent AuÀ S bond (AuNNP-PEG-N 3 ). The grafted PEG brushes provided sufficient azido groups to conjugate IR1048-DEVD-Alkyne.…”

Section: Synthesis and Characterization Of The Nanoprobementioning

confidence: 99%

An Activatable Hybrid Organic–Inorganic Nanocomposite as Early Evaluation System of Therapy Effect

Feng

et al. 2021

Angewandte Chemie

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Delays in evaluating cancer response to radiotherapy (RT) usually reduce therapy effect or miss the right time for treatment optimization. Hence, exploring timely and accurate methods enabling one to gain insights of RT response are highly desirable. In this study, we have developed an apoptosis enzyme (caspase-3) activated nanoprobe for early evaluation of RT efficacy. The nanoprobe bridged the nanogapped gold nanoparticles (AuNNPs) and the second near-infrared window (NIR-II) fluorescent (FL) molecules (IR-1048) through a caspase-3 specific peptide sequence (DEVD) (AuNNP@DEVD-IR1048). After X-ray irradiation, caspase-3 was activated to cut DEVD, turning on both NIR-II FL and PA imaging signals. The increased NIR-II FL/PA signals exhibited a positive correlation with the content of caspase-3. Moreover, the amount of the activated caspase-3 was negatively correlated with the tumor size. The results underscore the role of the caspase-3 activated by X-ray irradiation in bridging the imaging signals variation and tumor inhibition rate. Overall, activatable NIR-II FL/PA imaging was successfully used to timely predict and evaluate the RT efficacy. The evaluation system based on biomarkertriggered living imaging has the capacity to guide treatment decisions for numerous cancer types.

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Quantitative Assessment of Copper(II) in Wilson’s Disease Based on Photoacoustic Imaging and Ratiometric Surface-Enhanced Raman Scattering

Cited by 62 publications

References 56 publications

Stimuli‐Responsive Hybrid Vesicle for Tumor Dual‐Model NIR‐II Photoacoustic and Fluorescence Imaging and Precise Radiotherapy

Stimuli‐Responsive Hybrid Vesicle for Tumor Dual‐Model NIR‐II Photoacoustic and Fluorescence Imaging and Precise Radiotherapy

Semiconductor-based surface enhanced Raman scattering (SERS): from active materials to performance improvement

An Activatable Hybrid Organic–Inorganic Nanocomposite as Early Evaluation System of Therapy Effect

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