Eicosapentaenoic acid levels predict prognosis of peripheral artery disease caused by aortoiliac artery lesions

Ito, Naruhiko; Hishikari, Keiichi; Abe, Fumiyuki; Kanno, Yoshinori; Iiya, Munehiro; Murai, Tadashi; Hikita, Hiroyuki; Takahashi, Atsushi; Yonetsu, Taishi; Sasano, Tetsuo

doi:10.1016/j.numecd.2020.08.030

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Several studies have reported that high plasma EPA/AA ratio is an atherosclerotic biomarker reflecting the risk of LEAEs and MACEs in patients with PAD. 13 , 14) The reduced risks associated with high EPA/AA ratio could be ascribed to either a greater role of EPA in stabilizing atherosclerotic plaque or a smaller role of AA in destabilizing atherosclerotic plaque. 28) In the current study, Kaplan–Meier analysis showed significant differences in the LEAEs and MACEs divided into two groups based on EPA/AA ratio with median.…”

Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic Acid Level Predicts Long-Term Survival and Cardiovascular or Limb Event in Peripheral Arterial Disease

Kumakura,

Funada,

Matsuo

et al. 2024

Annals of Vascular Diseases

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Objectives: We examined the relationship between plasma eicosapentaenoic acid (EPA) level and long-term all-cause death (ACD) and cardiovascular or limb events in patients with peripheral arterial disease (PAD). Method: We performed a prospective cohort study on 637 PAD patients. The endpoints were ACD, major adverse cardiovascular events (MACEs), and lower extremity arterial events (LEAEs). Results: The incidences of ACD, MACEs, and LEAEs had correlation with EPA levels (p <0.05). Plasma EPA level had significant positive correlations with high-density lipoprotein cholesterol, triglyceride, and estimated glomerular filtration rate (eGFR), and negative correlation with C-reactive protein (CRP). In Cox stepwise multivariate analysis, lower EPA (hazard ratio [HR]: 0.996, 95% confidence interval [CI]: 0.993–1.000, p = 0.034), ankle brachial pressure index (ABI), body mass index, serum albumin, eGFR, age, CRP, D-dimer, critical limb ischemia, diabetes, cerebrovascular disease (CVD), and statin were related to ACD (p <0.05); lower EPA (HR: 0.997, 95% CI: 0.994–1.000, p = 0.038), ABI, serum albumin, eGFR, age, diabetes, coronary heart disease, CVD, and statin were related to MACEs (p <0.05); and lower EPA (HR: 0.988, 95% CI: 0.982–0.993, p <0.001), ABI, and low-density lipoprotein cholesterol were related to LEAEs (p <0.05). Conclusions: Low plasma EPA level was a significant risk factor for ACD, MACEs, and LEAEs in patients with PAD.

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Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic Acid Level Predicts Long-Term Survival and Cardiovascular or Limb Event in Peripheral Arterial Disease

Kumakura,

Funada,

Matsuo

et al. 2024

Annals of Vascular Diseases

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“…Eicosapentaenoic acid deficiency might be correlated with a higher incidence of MALE and MACE [449,450] Synthetic Fibrate…”

Section: Pufasmentioning

confidence: 99%

“…Humans do not have the ability to synthesize PUFAs, which are mainly present in fish and vegetable oils, nuts and seeds and foods with known anti-atherogenic effects [658,659]. Individuals with advanced stages of PAD undergoing revascularization may require supplementation of their diet with PUFA-rich foods given that low plasma levels of eicosapentaenoic acid correlate with the incidence of MALE and MACE [449,450].…”

Section: Pad Of Lower Limbs and Nutrientsmentioning

confidence: 99%

Dietary Risk Factors and Eating Behaviors in Peripheral Arterial Disease (PAD)

Cecchini

Biscetti

Rando

et al. 2022

IJMS

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Dietary risk factors play a fundamental role in the prevention and progression of atherosclerosis and PAD (Peripheral Arterial Disease). The impact of nutrition, however, defined as the process of taking in food and using it for growth, metabolism and repair, remains undefined with regard to PAD. This article describes the interplay between nutrition and the development/progression of PAD. We reviewed 688 articles, including key articles, narrative and systematic reviews, meta-analyses and clinical studies. We analyzed the interaction between nutrition and PAD predictors, and subsequently created four descriptive tables to summarize the relationship between PAD, dietary risk factors and outcomes. We comprehensively reviewed the role of well-studied diets (Mediterranean, vegetarian/vegan, low-carbohydrate ketogenic and intermittent fasting diet) and prevalent eating behaviors (emotional and binge eating, night eating and sleeping disorders, anorexia, bulimia, skipping meals, home cooking and fast/ultra-processed food consumption) on the traditional risk factors of PAD. Moreover, we analyzed the interplay between PAD and nutritional status, nutrients, dietary patterns and eating habits. Dietary patterns and eating disorders affect the development and progression of PAD, as well as its disabling complications including major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Nutrition and dietary risk factor modification are important targets to reduce the risk of PAD as well as the subsequent development of MACE and MALE.

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Positive association between urinary albumin-creatinine ratio and lower extremity peripheral arterial disease in Chinese diabetes patients: A cross-section study with propensity score matching analysis

Wang

Yuan²,

Ding³

et al. 2023

Nutrition, Metabolism and Cardiovascular Diseases

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Eicosapentaenoic acid levels predict prognosis of peripheral artery disease caused by aortoiliac artery lesions

Cited by 3 publications

References 22 publications

Eicosapentaenoic Acid Level Predicts Long-Term Survival and Cardiovascular or Limb Event in Peripheral Arterial Disease

Eicosapentaenoic Acid Level Predicts Long-Term Survival and Cardiovascular or Limb Event in Peripheral Arterial Disease

Dietary Risk Factors and Eating Behaviors in Peripheral Arterial Disease (PAD)

Positive association between urinary albumin-creatinine ratio and lower extremity peripheral arterial disease in Chinese diabetes patients: A cross-section study with propensity score matching analysis

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