Characteristics and outcomes of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients admitted to the intensive care unit: A multicenter retrospective cohort study

Alfraij, Abdulla; Alamir, Abdulrahman; Al-Otaibi, Abdulnasir; Alsharrah, Danah; Al-Daithan, Abdulrahman; Kamel, Ahmed; Almutairi, Muna; Alshammari, Salman; Almazyad, Mohammed; Macarambon, Jara Mia; Alghounaim, Mohammad

doi:10.1016/j.jiph.2020.12.010

Cited by 34 publications

(38 citation statements)

References 26 publications

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“…The remaining studies were from Brazil, Oman, Congo, Turkey, UK, Colombia, Kosovo, and Indonesia. Detailed data on the characteristics of the conclusive studies are given in Table S1 [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…The review demonstrated the significant global healthcare hospital prescribing of antimicrobials, which might be a temporary pattern associated with the serious pandemic. Since the first wave of this pandemic, multiple regional protocols included empirical antimicrobials such as ceftriaxone and azithromycin, leading to a substantial increase in antimicrobial consumption at various healthcare settings [ 36 , 37 ]. In accordance, based on our findings, third generation cephalosporin (36.8%) and azithromycin (34.2%) antibiotics were the most prevalent antimicrobial agents reported during the management of COVID-19 in patients admitted to ICUs ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

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Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review

Abu-Rub

Abdelrahman

Johar³

et al. 2021

Antibiotics

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The prevalence of patients admitted to intensive care units (ICUs) with SARS-CoV-2 infection who were prescribed antibiotics is undetermined and might contribute to the increased global antibiotic resistance. This systematic review evaluates the prevalence of antibiotic prescribing in patients admitted to ICUs with SARS-CoV-2 infection using PRISMA guidelines. We searched and scrutinized results from PubMed and ScienceDirect databases for published literature restricted to the English language up to 11 May 2021. In addition, we included observational studies of humans with laboratory-confirmed SARS-CoV-2 infection, clinical characteristics, and antibiotics prescribed for ICU patients with SARS-CoV-2 infections. A total of 361 studies were identified, but only 38 were included in the final analysis. Antibiotic prescribing data were available from 2715 patients, of which prevalence of 71% was reported in old age patients with a mean age of 62.7 years. From the reported studies, third generation cephalosporin had the highest frequency amongst reviewed studies (36.8%) followed by azithromycin (34.2%). The estimated bacterial infection in 12 reported studies was 30.8% produced by 15 different bacterial species, and S. aureus recorded the highest bacterial infection (75%). The fundamental outcomes were the prevalence of ICU COVID-19 patients prescribed antibiotics stratified by age, type of antibiotics prescribed, and the presence of co-infections and comorbidities. In conclusion, more than half of ICU patients with SARS-CoV-2 infection received antibiotics, and prescribing is significantly higher than the estimated frequency of identified bacterial co-infection.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review

Abu-Rub

Abdelrahman

Johar³

et al. 2021

Antibiotics

View full text Add to dashboard Cite

show abstract

“… 63 , 64 In addition, thrombocytopenia (<150×10 9 /L) is also common in children with severe SARS-CoV-2 infection. 65 A single-center retrospective study in Turkey showed that the average platelet value of children with COVID-19 was significantly lower than others, and platelet reduction was more obvious in severe COVID-19 children, which was closely related to the severity of the disease (P<0.05). 35 A study by Davies et al 66 showed that the platelets of children with severe COVID-19 children were significantly less than 150×10 9 /L on the first day of admission.…”

Section: Covid-19 and Plateletsmentioning

confidence: 98%

SARS-CoV-2 Infection: Differences in Hematological Parameters Between Adults and Children

Liu¹,

She²,

Bai³

et al. 2021

IJGM

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Since December 2019, corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, posing a huge threat to human health, and the current epidemic prevention situation is still severe. Hematological parameters directly reflect the damage of SARS-CoV-2 to human blood cells, which can better assess the severity and prognosis of patients infected with COVID-19, but hematological parameters have some differences between adults and children. This article comprehensively reviews the differences in hematological parameters between adults and children after SARS-CoV-2 infection, and provides a reference for the diagnosis and treatment of COVID-19.

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“…Severe disease is more frequent in infants than in older children, and in children with other medical conditions or elevated levels of the inflammatory marker, C‐reactive protein 4 . Concerns have been expressed since the beginning of the COVID‐19 pandemic that the numbers of hospitalisations, critical care admissions, and deaths of children with comorbid conditions were high, but the situation is unclear 5,6 . Of particular concern is the paediatric inflammatory multisystem syndrome temporally associated with SARS‐CoV‐2 (PIMS‐TS), or multisystem inflammatory syndrome, 7 a complication reported in settings with high rates of community transmission 8,9 .…”

mentioning

confidence: 99%

The characteristics of SARS‐CoV‐2‐positive children who presented to Australian hospitals during 2020: a PREDICT network study

Ibrahim

Tham

Chong

et al. 2021

Medical Journal of Australia

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Objectives To examine the epidemiological and clinical characteristics of SARS‐CoV‐2‐positive children in Australia during 2020. Design, setting Multicentre retrospective study in 16 hospitals of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network; eleven in Victoria, five in four other Australian states. Participants Children aged 0‒17 years who presented to hospital‐based COVID‐19 testing clinics, hospital wards, or emergency departments during 1 February ‒ 30 September 2020 and who were positive for SARS‐CoV‐2. Main outcome measures Epidemiological and clinical characteristics of children positive for SARS‐CoV‐2. Results A total of 393 SARS‐CoV‐2‐positive children (181 girls, 46%) presented to the participating hospitals (426 presentations, including 131 to emergency departments [31%]), the first on 3 February 2020. Thirty‐three children presented more than once (8%), including two who were transferred to participating tertiary centres (0.5%). The median age of the children was 5.3 years (IQR, 1.9‒12.0 years; range, 10 days to 17.9 years). Hospital admissions followed 51 of 426 presentations (12%; 44 children), including 17 patients who were managed remotely by hospital in the home. Only 16 of the 426 presentations led to hospital medical interventions (4%). Two children (0.5%) were diagnosed with the paediatric inflammatory multisystem syndrome temporally associated with SARS‐CoV‐2 (PIMS‐TS). Conclusion The clinical course for most SARS‐CoV‐2‐positive children who presented to Australian hospitals was mild, and did not require medical intervention.

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Characteristics and outcomes of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients admitted to the intensive care unit: A multicenter retrospective cohort study

Cited by 34 publications

References 26 publications

Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review

Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review

SARS-CoV-2 Infection: Differences in Hematological Parameters Between Adults and Children

The characteristics of SARS‐CoV‐2‐positive children who presented to Australian hospitals during 2020: a PREDICT network study

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