Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

Rico, Angélica; Dollard, Sheila C.; Valencia, Diana; Corchuelo, Sheryll; Tong, Van T.; Laiton‐Donato, Katherine; Amin, Minal M.; Benavides, Mónica; Wong, Phili; Newton, Suzanne; Daza, Marcela; Cates, Jordan; González, Maribel Castellano; Zambrano, Laura D.; Mercado, Marcela; Ailes, Elizabeth C.; Rodríguez, Helena Martínez; Gilboa, Suzanne M.; Acosta, Jacqueline; Ricaldi, Jessica N; Peláez, Dioselina; Honein, Margaret A.; Ospina, Martha; Lanzieri, Tatiana M.

doi:10.1002/jmv.26815

Cited by 9 publications

(9 citation statements)

References 11 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even if all of the infants whose test results were missing had negative testing for CMV, we would have identified 4 transmissions among 243 infants at risk, which would have resulted in a rate of congenital CMV of 1.6%, still higher than is observed in the general population. It is important to note that the lower limit of our 95%CI for CMV transmissions was 0.7%, which is similar to the rate of 0.6–0.8% described in highly CMV-seropositive, HIV-uninfected populations ( 6 – 8 ). In addition, two infants with congenital CMV were born to women who initiated ART late in pregnancy; therefore, it is possible that transmission rates may be lower among WLHIV who are virally suppressed on ART prior to conception.…”

Section: Discussionsupporting

confidence: 81%

“…Within high-income countries, seroprevalence correlates with nonwhite race, internationally-born status, and lower socioeconomic backgrounds; some studies have also shown higher seroprevalence among people living with HIV than in the general population ( 3 – 5 ). In areas with near-universal maternal CMV seroprevalence, the incidence of congenital CMV is 6–8 per 1,000 infants, resulting in a mother-to-child transmission rate of <1% ( 6 – 8 ). In our cohort of WLHIV, congenital CMV infection occurred at a more than 2-fold higher rate than is observed in the general population.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Congenital Co-infections Among HIV-Exposed Infants Born to Mothers on Antiretroviral Treatment in the United States

Smith

Silveira²,

Crotteau³

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundMany women living with HIV (WLHIV) are co-infected with cytomegalovirus (CMV), Toxoplasma gondii (T gondii), and/or hepatitis C virus (HCV). The rates of congenital or perinatal transmission of these co-infections are not well defined in the current era, when most WLHIV receive antiretroviral therapy (ART) during pregnancy.MethodsRetrospective review of infants of WLHIV born between 2009–2019. Mothers were screened for antibodies to CMV, T. gondii, and HCV; chronic HCV infection was confirmed using plasma RNA PCR. Infants whose mothers had positive/unknown serostatus were screened for CMV using urine or saliva DNA PCR or culture at ≤3 weeks of life; T. gondii using serology at ≤1 month; and HCV using plasma RNA PCR at ≤6 months and serology at ≥12 months.ResultsThe study included 264 infants from 255 pregnancies in 191 mothers. At delivery, the median (IQR) CD4 count was 569 (406–748) cells/mm3 and plasma HIV load was 0 (0–24) RNA copies/mL. Among 243 infants born to CMV-seropositive (209) or CMV-missed serostatus (25) mothers, 163 (67.1%) were tested for CMV. Four infants had CMV detected, resulting in a rate of congenital infection of 2.5%. Among 65 infants from 54 (21.2%) pregnancies in T. gondii-seropositive women and 8 in women with unknown T. gondii-serostatus, one acquired congenital toxoplasmosis in the setting of acute maternal T. gondii infection. There were no episodes of vertical transmission from mothers with latent toxoplasmosis. Among 18 infants from 13 (5.1%) pregnancies in HCV RNA PCR-positive women and 4 in women with unknown HCV serostatus, there were no congenital or perinatal HCV transmissions.ConclusionsIn a US cohort of pregnant WLHIV on ART, we identified high maternal CMV seroprevalence and a high rate of congenital CMV infection. We did not identify any congenital or perinatal transmissions of T. gondii or HCV among mothers who had latent or chronic infections. Our data support screening pregnant WLHIV and their infants for CMV and suggest that the rates of congenital and perinatal T. gondii and HCV infections among infants born to WLHIV on ART may be lower in the era of effective ART.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Congenital Co-infections Among HIV-Exposed Infants Born to Mothers on Antiretroviral Treatment in the United States

Smith

Silveira²,

Crotteau³

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…A total of 77 articles were included in this meta-analysis. The final studies were from 36 countries (eFigure 3 in the Supplement ) on 5 continents and are categorized by World Health Organization regions as follows: Africa, 6 countries (6 studies) 30 , 31 , 32 , 33 , 34 , 35 ; Americas–Latin, 5 countries (9 studies) 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ; Americas–US and Canada, 2 countries (18 studies) 17 , 18 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ; Eastern Mediterranean, 1 country (3 studies) 61 , 62 , 63 ; Europe, 16 countries (24 studies) 8 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ,…”

Section: Resultsmentioning

confidence: 99%

Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening

et al. 2021

View full text Add to dashboard Cite

Key Points Question What are the pooled prevalence of congenital cytomegalovirus infection and factors associated with the rates in high-income and low- and middle-income countries? Findings In this systematic review and meta-analysis including 77 studies from 36 countries comprising 515 646 infants younger than 3 weeks, the pooled overall prevalence of congenital cytomegalovirus was 0.67%. The infection burden was 3-fold greater in low- and middle-income countries than in high-income countries. Lower rates were reported in screening methods using blood compared with urine or saliva. Meaning The findings of this study suggest that low- and middle-income countries incur the greatest infection burden of congenital cytomegalovirus; a global effort to address congenital cytomegalovirus in regions with the greatest prevalence is needed to reduce disease incidence and morbidity.

show abstract

“…The seropositivity prevalence for CMV before transplantation in our study was 91% in donors and 92% in recipients, which agrees with that reported in adult patients undergoing HSCT in our institution 44 and other population contexts in our country. [45][46][47] This high prevalence could be related to the sociodemographic characteristics, high rates of poverty and overcrowding within the population.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and incidence of cytomegalovirus viremia and disease in pediatric patients with allogeneic hematopoietic stem cell transplantation: An 8‐year single‐center experience in Latin America

Aristizábal

Pérez

Niño

et al. 2022

Pediatric Transplantation

View full text Add to dashboard Cite

Background: Cytomegalovirus infection represents a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. This study aimed to evaluate the incidence of viremia and disease due to cytomegalovirus and the risk factors in pediatric patients with hematopoietic stem cell transplantation in our institution. Methods: This was a retrospective cohort of patients under 19 years of age who underwent allogeneic hematopoietic stem cell transplantation due to any indication between 2012 and 2019. The analysis included the diagnosis of cytomegalovirus viremia or disease during post-transplant follow-up, evaluation of risk factors, and outcomes.The statistical analysis included univariate and multivariate analyses, and the cumulative incidence of cytomegalovirus viremia was determined by the Kaplan-Meier method using STATA 14 statistical software.Results: A total of 182 transplants were included. At 100 days, the cumulative incidence of cytomegalovirus viremia was 70.5%, and that of cytomegalovirus disease was 4.7%. Overall survival at 2 years was 74%, and event-free survival was 64%. The remaining demographic characteristics were not predictors of infection. There was no association between viremia and relapse or survival of the patients. Higher mortality was noted in cytomegalovirus disease.Conclusions: During the study period, the incidence of cytomegalovirus disease was similar to that of other pediatric reports, but the incidence of viremia was higher. Preemptive therapy has diminished disease rates and death due to infection. Viral load cutoff points should be standardized to guide treatment and avoid myelotoxicity.

show abstract

Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

Cited by 9 publications

References 11 publications

Congenital Co-infections Among HIV-Exposed Infants Born to Mothers on Antiretroviral Treatment in the United States

Congenital Co-infections Among HIV-Exposed Infants Born to Mothers on Antiretroviral Treatment in the United States

Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening

Risk factors and incidence of cytomegalovirus viremia and disease in pediatric patients with allogeneic hematopoietic stem cell transplantation: An 8‐year single‐center experience in Latin America

Contact Info

Product

Resources

About