Dietary administration of cumin-derived cuminaldehyde induce neuroprotective and learning and memory enhancement effects to aging mice

Abstract

Cuminaldehyde (CA) is one of the major compounds of the essential oil of Cuminum cyminum . The aim of this study was to evaluate the effects of CA on aging, specifically on spatial learning and memory. To achieve our objective, an in vitro study on SH-SY5Y cells was performed to analyze the neuroprotective effect of CA against dexamethasone using the MTT assay. An in vivo study was performed for evaluation of the spatial learning and memory using Morris water maze (MWM). RT-PCR was performed to quantify the expression of specific genes ( Bdnf, Icam and ApoE ) in the mice brain. The results obtained showed a neuroprotective effect of CA against dexamethasone-induced neuronal toxicity. The escape latency of CA-treated aged mice was significantly decreased as compared to the water-treated aged mice after 4 days of training in MWM. Moreover, CA treatment up-regulated the gene expression of Bdnf , Icam and ApoE , while it down-regulated the gene expression of IL-6 . These findings suggest that CA has a neuroprotective effect, as well as a spatial learning and memory enhancement potential through the modulation of genes coding for neurotrophic factors and/or those implicated in the imbalance of neural circuitry and impairment of synaptic plasticity. Cuminaldehyde (CA) is one of the major compound of the essential oil of Cuminum cyminum . The aim of this study was to evaluate the effects of CA on aging, specifically on spatial learning and memory. To achieve our objective, an in vitro study on SH-SY5Y cells was performed to analyze the neuroprotective effect of CA against dexamethasone using the MTT assay. An in vivo study was performed for evaluation of the spatial learning and memory using Morris water maze (MWM). RT-PCR was performed to quantify the expression of specific genes ( Bdnf, Icam and ApoE ) in the mice brain. The results obtained showed a neuroprotective effect of CA against dexamethasone-induced neuronal toxicity. The escape latency of CA-treated aged mice was significantly decreased as compared to the water-treated aged mice after 4 days of training in MWM. Moreover, CA treatment up-regulated the gene expression of Bdnf , Icam and ApoE , while it down-regulated the gene expression of IL-6 . These findings suggest that CA has a neuroprotective effect, as well as a spatial learning and memory enhancement potential through the modulation of genes coding for neurotrophic factors and/or those implicated in the imbalance of neural circuitry and impairment of synaptic plasticity.

Mechanistic Aspects of Apiaceae Family Spices in Ameliorating Alzheimer’s Disease

“…The methanolic extract of A. graveolens seeds demonstrated moderate neuroprotective effects in PC12 cells treated with Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) aggregates with an ED50 value of 18.8 µg/mL [45]. The administration of A. graveolens ethanolic leaves extract significantly improved the learning and memory damage induced by scopolamine in Morris water maze and elevated plus maze experiments.…”

“…Cuminaldehyde was displayed to play a role in neuroprotection and spatial learning and memory enhancement through the modulation of genes (Bdnf, Icam, ApoE, IL-6) coding for neurotrophic factors and/or those associated in damaging synaptic plasticity in both in vitro and in vivo experiments [28]. Memory-enhancing activity of C. cyminum water extract was reported in animal models of AD by maintaining the levels of antioxidant enzymes [55,56].…”

Anti-Aging Activity and Modes of Action of Compounds from Natural Food Sources

“…Cuminaldehyde, an aromatic monoterpenoid volatile compound, is an aromatic oily aldehyde found in essential oils obtained from the cumin Cuminum cyminum [171]. Cuminaldehyde was shown to be able to upregulate the expression of Bdnf, Icam and ApoE but downregulate the expression of IL-6 in the brains of aged rats, suggesting that cuminaldehyde has a neuroprotective effect [171]. Asperuloside is the main bioactive compound of iridoid, belonging to monoterpenoid extracted from the Chinese herb Du Zhong Eucommia ulmoides male flower.…”