The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies

Zhang, Yuan-Feng; Xu, Zhiqiang; Zhou, Hongjie; Liu, Ya-Zhen; Jiang, Xiaojiang

doi:10.1097/wnf.0000000000000419

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…A reduction of cancer mortality is not the only expected positive health effect of vitamin D food fortification. RCT based evidence of beneficial health effects of vitamin D supplementation is still limited to a few health outcomes, such as fall and fracture risk [ 29 ] (at least when combined with calcium), upper respiratory infections [ 30 ], autoimmune disease [ 31 ], increased muscle strength [ 32 ], improved cognitive function in older adults with Alzheimer’s disease [ 33 ], reductions in migraine frequency and severity [ 34 ], positive effects on transferrin saturation and iron status [ 35 ], and on cardio-metabolic indicators in obese adults [ 36 ]. An umbrella review of cohort studies, RCTs and Mendelian randomization studies suggested lower risk of acute respiratory infections, dementia, cognitive decline, and depression mainly in elderly [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths

et al. 2022

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Background: Meta-analyses of randomized controlled trials have shown that vitamin D supplementation reduces cancer mortality by 13%. Vitamin D fortification of foods may increase vitamin D levels in a similar manner as vitamin D supplementation and could achieve similar reductions in cancer mortality. Whereas some European countries already implemented widespread fortification of foods with vitamin D, in other countries only few or no foods are fortified. In this study, we estimated the reduction in cancer mortality presumably already achieved by current fortification policies in 2017 and the potential for further reductions if all countries had effective fortification. Methods: We reviewed scientific literature, publicly available information, and contacted health authorities to obtain information on current vitamin D food fortification policies in 34 European countries. Together with country-specific cancer death statistics from Eurostat, information on life expectancy, and country-specific fortification policies, we used data from studies on supplementation and serum 25(OH)D increases and cancer mortality to estimate numbers of probably already prevented cancer deaths and numbers of potentially further preventable deaths and years of life lost. Results: Current vitamin D fortification is estimated to prevent approximately 11,000 in the European Union and 27,000 cancer deaths in all European countries considered per year. If all countries considered here would implement adequate vitamin D fortification of foods, an estimated additional 129,000 cancer deaths (113,000 in the European Union) could be prevented, corresponding to almost 1.2 million prevented years of life lost (1.0 million in the EU) or approximately 9% of cancer deaths (10% in the EU). Interpretation: Systematic fortification of foods might considerably reduce the burden of cancer deaths in Europe.

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Section: Discussionmentioning

confidence: 99%

Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths

et al. 2022

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“…Additionally, the concentration of vitamin D in the blood has also been associated with migraine characteristics, as migraine patients with vitamin D deficiency are more likely to suffer frequent and severe attacks than migraine patients with adequate levels of vitamin D [ 146 , 149 ]. Vitamin D administration was found to be effective in alleviating migraine-related outcomes in a meta-analysis of five randomized controlled trials [ 150 ].…”

Section: Dietary Components Affecting Glutamate Neurotoxicity and Mig...mentioning

confidence: 99%

Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine

Martami,

Holton

2023

Nutrients

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Glutamate, the main excitatory neurotransmitter in the central nervous system, is implicated in both the initiation of migraine as well as central sensitization, which increases the frequency of migraine attacks. Excessive levels of glutamate can lead to excitotoxicity in the nervous system which can disrupt normal neurotransmission and contribute to neuronal injury or death. Glutamate-mediated excitotoxicity also leads to neuroinflammation, oxidative stress, blood-brain barrier permeability, and cerebral vasodilation, all of which are associated with migraine pathophysiology. Experimental evidence has shown the protective effects of several nutrients against excitotoxicity. The current review focuses on the mechanisms behind glutamate’s involvement in migraines as well as a discussion on how specific nutrients are able to work towards restoring glutamate homeostasis. Understanding glutamate’s role in migraine is of vital importance for understanding why migraine is commonly comorbid with widespread pain conditions and for informing future research directions.

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“…4 Several randomized clinical trials have shown a beneficial effect of vitamin D supplementation in the therapy of migraine in adults [14][15][16][17][18] and children, 19 one of them using vitamin D in combination with simvastatin, 14 and another showing a synergistic effect with topiramate. Two meta-analyses of randomized clinical trials showed improvement in migraine based on a reduced number of headache days, 20,21 the frequency of headache attacks. 20,21 headache severity, 20 and Migraine Disability Assessment Score, 20,21 but no effect in the duration of the migraine attack.…”

Section: Introductionmentioning

confidence: 99%

“…Two meta‐analyses of randomized clinical trials showed improvement in migraine based on a reduced number of headache days, 20 , 21 the frequency of headache attacks. 20 , 21 headache severity, 20 and Migraine Disability Assessment Score, 20 , 21 but no effect in the duration of the migraine attack. 21 In one study, patients under vitamin D therapy showed a reduction in serum levels of inducible nitric oxide synthase (iNOS) and a trend towards lower serum interleukin 6 (IL‐6) levels compared with the placebo group, while serum levels of IL‐10 and cyclooxygenase‐2 (Cox‐2) were similar in both groups.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor and binding protein genes variants in patients with migraine

García‐Martín,

Navarro‐Muñoz,

Ayuso

et al. 2023

Ann Clin Transl Neurol

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Background/ObjectivesSeveral studies have shown a relationship between vitamin D and migraine, including the association between decreased serum 25‐hydroxyvitamin D in patients with migraine and the positive effects of vitamin D supplementations in the therapy of this disease. Two single‐nucleotide variants (SNVs) vitamin D receptor (VDR) gene, VDR rs2228570, and VDR rs731236 have shown an association with migraine risk in a previous case–control association study, while an exome sequencing study identified a rare variant in GC vitamin D binding protein gene. This study aims to look for the association between several common variants in these two genes and the risk for migraine.MethodsWe genotyped 290 patients diagnosed with migraine and 300 age‐matched controls using specific TaqMan assays for VDR rs2228570, VDR rs731236, VDR rs7975232, VDR rs739837, VDR rs78783628, GC rs7041, and GC rs4588 SNVs.ResultsWe did not find an association between these SNVs and the risk for migraine. None of these SNVs were related to the positivity of a family history of migraine or with the presence of aura. The VDR rs731236A allele showed a significant association with the triggering of migraine attacks by ethanol (Pc = 0.007).ConclusionsIn summary, the results of the current study suggest a lack of association between common SNVs in the VDR and GC gene and the risk of developing migraine. The possible relationship between VDR rs731236 and the triggering of migraine episodes with ethanol deserves future studies.

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The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies

Cited by 7 publications

References 26 publications

Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths

Vitamin D food fortification in European countries: the underused potential to prevent cancer deaths

Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine

Vitamin D receptor and binding protein genes variants in patients with migraine

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