Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

Chen, Wei; Liu, Chuang; Ji, Xiaoyuan; Joseph, John; Tang, Zhongmin; Ouyang, Jun; Xiao, Yufen; Kong, Na; Joshi, Nitin; Farokhzad, Omid C.; Tao, Wei; Xie, Tian

doi:10.1002/anie.202016330

Cited by 136 publications

(73 citation statements)

References 63 publications

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“…The photothermal conversion efficiency (η) of AsNDs@PEG was calculated as 37.85%, which is higher than a majority of PTT agents, including black phosphorous quantum dots, MoS 2 nanosheets, Bi 2 S 3 nanorods, etc. [ 26,27,32 ]…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, arsenene is a semiconductor with indirect bandgaps, [ 14–16 ] processing a potential to be discovered as near‐infrared (NIR) light‐responsive photothermal therapy (PTT) agents, [ 17–20 ] which has already yielded significant impacts in the preclinical and clinical treatments for solid tumors. [ 19,21–28 ] However, it remains difficult to efficiently obtain arsenene with high monoelemental purity and suitable size to achieve the abovementioned selective killing effects for solid tumor therapy. In addition, the feasibility of such a strategy has not yet been explored.…”

Section: Introductionmentioning

confidence: 99%

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Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy

et al. 2021

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Arsenical drugs have achieved hallmark success in treating patients with acute promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult with the contradiction between the therapeutic efficacy and the systemic toxicity. Here, leveraging efforts from materials science, biocompatible PEGylated arsenene nanodots (AsNDs@PEG) with high monoelemental arsenic purity that can selectively and effectively treat solid tumors are synthesized. The intrinsic selective killing effect of AsNDs@PEG is closely related to high oxidative stress in tumor cells, which leads to an activated valence‐change of arsenic (from less toxic As0 to severely toxic oxidation states), followed by decreased superoxide dismutase activity and massive reactive oxygen species (ROS) production. These effects occur selectively within cancer cells, causing mitochondrial damage, cell‐cycle arrest, and DNA damage. Moreover, AsNDs@PEG when applied in a multi‐drug combination strategy with β‐elemene, a plant‐derived anticancer drug, achieves synergistic antitumor outcomes, and its newly discovered on‐demand photothermal properties facilitate the elimination of the tumors without recurrence, potentially further expanding its clinical utility. In line of the practicability for a large‐scale fabrication and negligible systemic toxicity of AsNDs@PEG (even at high doses and with repetitive administration), a new‐concept arsenical drug with high therapeutic efficacy for selective solid tumor therapy is provided.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy

et al. 2021

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“…This unique feature makes exfoliation of bulk Sn into 2D SnNSs through external force at ultralow temperature infinitely possibilities [27]. Additionally, liquid-phase exfoliation is also a classic top-down method of preparing 2D nanomaterials, and many 2D nanomaterials fabricated through liquid-phase exfoliation have been reported [35][36][37][38][39]. Our group also synthesized some 2D nanomaterials such as black phosphorus [40][41][42][43][44], antimonene [45,46], and germanene [47,48] by the liquidphase exfoliation method.…”

Section: Introductionmentioning

confidence: 95%

Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Ouyang

Zhang

et al. 2021

Nano-Micro Lett.

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Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.

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“…Two-dimensional (2D) materials such as photothermal therapeutic agents have found a wide of applications in nanomedicine. [46][47][48][49][50][51][52][53][54][55][56][57] Black phosphorus (BP), is an emerging 2D crystalline material with a unique layered structure, holding great promise for bone regeneration due to its excellent biocompatibility, adjustable bandgap, and high photothermal conversion efficiency. [58][59][60][61][62] Therefore, BP has been widely applied in the fields of cancer therapy, anti-inflammation, and bone regeneration using the highefficiency photothermal conversion of BP under near-infrared (NIR) irradiation (Figure 4A).…”

Section:  Multifunctional Materials and Combined Therapiesmentioning

confidence: 99%

Biomaterials and nanomedicine for bone regeneration: Progress and future prospects

et al. 2021

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Bone defects pose a heavy burden on patients, orthopedic surgeons, and public health resources. Various pathological conditions cause bone defects including trauma, tumors, inflammation, osteoporosis, and so forth. Auto‐ and allograft transplantation have been developed as the most commonly used clinic treatment methods, among which autologous bone grafts are the golden standard. Yet the repair of bone defects, especially large‐volume defects in the geriatric population or those complicated with systemic disease, is still a challenge for regenerative medicine from the clinical perspective. The fast development of biomaterials and nanomedicine favors the emergence and promotion of efficient bone regeneration therapies. In this review, we briefly summarize the progress of novel biomaterial and nanomedical approaches to bone regeneration and then discuss the current challenges that still hinder their clinical applications in treating bone defects.

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Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

Cited by 136 publications

References 63 publications

Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy

Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy

Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Biomaterials and nanomedicine for bone regeneration: Progress and future prospects

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