T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner

Fan, Z. Y.; Zhang, Junzheng; Wang, Dan; Shen, Jie

doi:10.1016/j.ibmb.2020.103516

Cited by 6 publications

(2 citation statements)

References 80 publications

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“…In addition, Dac, Doc1 and Doc2, which have been associated with tissue morphogenesis (Fig. 4D) (Brás-Pereira et al, 2016;Paul et al, 2018;Fan et al, 2021), are not only expressed in bar-shaped SCs but also in initial and transitional PCs. Finally, SCENIC also reveals that Lim3 is highly enriched in SCs (Fig.…”

Section: Cell-type-specific Expression Of Transcription Factors and Regulatory Landscapementioning

confidence: 99%

A cell atlas of the fly kidney

Liu

et al. 2021

Preprint

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Like humans, insects rely on precise regulation of their internal environments to survive. The insect renal system consists of Malpighian tubules and nephrocytes that share similarities to the mammalian kidney. Studies of the Drosophila Malpighian tubules and nephrocytes have provided many insights into our understanding of the excretion of waste products, stem cell regeneration, protein reabsorption, and as human kidney disease models. Here, we analyzed single-nucleus RNA sequencing (snRNA-seq) data sets to characterize the cell types of the adult fly kidney. We identified 11 distinct clusters representing renal stem cells (RSCs), stellate cells (SCs), regionally specific principal cells (PCs), garland nephrocyte cells (GCs) and pericardial nephrocytes (PNs). Analyses of these clusters revealed many new interesting features. For example, we found a new, previously unrecognized cell cluster: lower segment PCs that express Esyt2. In addition, we find that the SC marker genes RhoGEF64c, Frq2, Prip and CG10939 regulate their unusual cell shape. Further, we identified transcription factors specific to each cluster and built a network of signaling pathways that are potentially involved in mediating cell-cell communication between Malpighian tubule cell types. Finally, cross-species analysis allowed us to match the fly kidney cell types to mouse kidney cell types and planarian protonephridia - knowledge that will help the generation of kidney disease models. To visualize this dataset, we provide a web-based resource for gene expression in single cells (https://www.flyrnai.org/scRNA/kidney/). Altogether, our study provides a comprehensive resource for addressing gene function in the fly kidney and future disease studies.

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Section: Cell-type-specific Expression Of Transcription Factors and Regulatory Landscapementioning

confidence: 99%

A cell atlas of the fly kidney

Liu

et al. 2021

Preprint

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“…A continual activation of Notch across segments leads to shortened legs with segmentation defects [ 191 , 192 , 193 ]. Many factors and pathways interact with Notch signaling to establish the segment boundaries, although the underlying mechanisms are not fully elucidated [ 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 ]. Proper Notch pathway activation is also vital for joint formation and leg growth [ 210 ].…”

Section: Notch Signaling In Insect Leg Developmentmentioning

confidence: 99%

Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions

Chen,

Li,

et al. 2023

IJMS

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Notch signaling is an evolutionarily conserved pathway which functions between adjacent cells to establish their distinct identities. Despite operating in a simple mechanism, Notch signaling plays remarkably diverse roles in development to regulate cell fate determination, organ growth and tissue patterning. While initially discovered and characterized in the model insect Drosophila melanogaster, recent studies across various insect species have revealed the broad involvement of Notch signaling in shaping insect tissues. This review focuses on providing a comprehensive picture regarding the roles of the Notch pathway in insect development. The roles of Notch in the formation and patterning of the insect embryo, wing, leg, ovary and several specific structures, as well as in physiological responses, are summarized. These results are discussed within the developmental context, aiming to deepen our understanding of the diversified functions of the Notch signaling pathway in different insect species.

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Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium

Sun

et al. 2023

Ecotoxicology and Environmental Safety

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T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner

Cited by 6 publications

References 80 publications

A cell atlas of the fly kidney

A cell atlas of the fly kidney

Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions

Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium

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