Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium

Sun, Liran; Mu, Yun Ping; Xu, Lu; Han, Xiaobing; Gu, Wei; Zhang, Min

doi:10.1016/j.ecoenv.2022.114486

Cited by 9 publications

(3 citation statements)

References 43 publications

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“…In addition, although less studied in plants, histone modifications have also been suggested as important players in the regulation of the defense response, with histone deacetylases playing a role in the transcriptional activation of several stress-responsive genes [37][38][39][40] . Histone re-organization during stress is an important part of the stress-induced transcriptional reprogramming in multiple eukaryotic organisms including mammals, Neurospora, and Drosophila, where repressive histone marks located in both facultative and constitutive heterochromatin (mainly the trimethylation of lysine 27 of histone H3, H3K27me3, and the di/trimethylation of lysine 9 of histone H3, H3K9me2/3, respectively) are redistributed under different types of stresses [41][42][43][44][45][46] . Nevertheless, the dynamics of these two marks under stress or their connection to DNA methylation is unexplored in plants.…”

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confidence: 99%

Heterochromatin re-organization associated with the transcriptional reprogramming under viral infection inArabidopsis

Annacondia,

Juarez-Gonzalez,

Cheng

et al. 2023

Preprint

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Epigenetic mechanisms are key regulators of genomic integrity and genic expression. Emerging evidence shows that epigenetic regulation is an important component of the transcriptional reprogramming during stress. Despite this, the overall stress-induced reprogramming of the different epigenetic marks and their targets are unknown. Here, we uncovered multiple epigenetic changes taking place during viral infection in Arabidopsis thaliana and their connection with gene expression. We find that cucumber mosaic virus (CMV) infection induces an overall reorganization of the repressive epigenetic marks H3K9me2, H3K27me3, and DNA methylation, which interact between them and are dynamic during infection. Overall, these epigenetic changes are involved in the reprogramming of the transcriptional program to adapt to the biotic stress, and might ensure genome stability through the transcriptional control of transposable elements (TEs). Mechanistically, we demonstrate that the catalytic component of the Polycomb Repressive Complex 2 (PRC2) CURLY LEAF (CLF) mediates the transcriptional repression of genes gaining H3K27me3 during viral infection and that mutants on that component induce resistance against CMV. Altogether, our results provide a complete picture of the epigenetic changes that occur during biotic stress and exemplify the overall dynamism of epigenetic regulation in eukaryotic organisms.

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confidence: 99%

Heterochromatin re-organization associated with the transcriptional reprogramming under viral infection inArabidopsis

Annacondia,

Juarez-Gonzalez,

Cheng

et al. 2023

Preprint

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“…The cellular immune response in insects includes phagocytosis and encapsulation by hemocytes when pathogens are recognized (Strand, 2008). The humoral immune system is based mainly on the Toll and IMD signaling pathways (Ali Mohammadie Kojour et al, 2020).…”

Section: Fight Not Ight?mentioning

confidence: 99%

Transcriptional reprogramming in the entomopathogenic fungus Metarhizium brunneum and its aphid host Myzus persicae during the switch between saprophytic and parasitic lifestyles

Reingold,

Faigenboim,

Matveev

et al. 2024

Preprint

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Background The fungus Metarhizium brunneum has evolved a remarkable ability to switch between different lifestyles. It develops as a saprophyte, an endophyte establishing mutualistic relationships with plants, or a parasite, enabling its use for the control of insect pests such as the aphid Myzus persicae. We tested our hypothesis that switches between lifestyles must be accompanied by fundamental transcriptional reprogramming, reflecting adaptations to different environmental settings. Results We combined high throughput RNA sequencing of M. brunneum in vitro and at different stages of pathogenesis to validate the modulation of genes in the fungus and its host during early infection. In agreement with our hypothesis, we observed transcriptional reprogramming in M. brunneum following conidial attachment, germination on the cuticle, and early-stage growth within the host. This involved the upregulation of genes encoding degrading enzymes and gene clusters involved in synthesis of secondary metabolites that act as virulence factors. The transcriptional response of the aphid host included the upregulation of genes potentially involved in antifungal activity, but antifungal peptides were not induced. We also observed the induction of a host flightin gene, which may be involved in wing formation and flight muscle development. Conclusions The switch from saprophytic to parasitic development in M. brunneum is accompanied by fundamental transcriptional reprogramming during the early phases of infection. The aphid host responds to fungal infection with its own transcriptional reprogramming, reflecting its inability to express antifungal peptides but featuring the induction of genes involved in winged morphs that may enable offspring to avoid the contaminated environment.

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“…In Drosophila melanogaster , the phenotypic defects of wings caused by cadmium can be inherited to the offspring, and this transgenerational inheritance effect may be related to the epigenetic regulation of histone methylation. Therefore, the adaptability of offspring should be considered when evaluating the toxicity and environmental risk of cadmium [ 7 ]. In a similar study [ 8 ] of D .…”

Section: Introductionmentioning

confidence: 99%

An epigenetic change in a moth is generated by temperature and transmitted to many subsequent generations mediated by RNA

Pavelka,

Poláková,

Pavelková

et al. 2024

PLoS ONE

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Epigenetic changes in sexually reproducing animals may be transmitted usually only through a few generations. Here we discovered a case where epigenetic change lasts 40 generations. This epigenetic phenomenon occurs in the short antennae (sa) mutation of the flour moth (Ephestia kuehniella). We demonstrate that is probably determined by a small RNA (e.g., piRNA, miRNA, tsRNA) and transmitted in this way to subsequent generations through the male and female gametes. The observed epigenetic change cancels sa mutation and creates a wild phenotype (a moth that appears to have no mutation). It persists for many generations (40 recorded). This epigenetic transgenerational effect (suppression homozygous mutation for short antennae) in the flour moth is induced by changes during ontogenetic development, such as increased temperature on pupae development, food, different salts in food, or injection of RNA from the sperm of already affected individuals into the eggs. The epigenetic effect may occasionally disappear in some individuals and/or progeny of a pair in the generation chain in which the effect transfers. We consider that the survival of RNA over many generations has adaptive consequences. It is mainly a response to environmental change that is transmitted to offspring via RNA. In this study, we test an interesting epigenetic effect with an unexpected length after 40 generations and test what is its cause. Such transfer of RNA to subsequent generations may have a greater evolutionary significance than previously thought. Based on some analogies, we also discuss of the connection with the SIR2 gene.

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Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium

Cited by 9 publications

References 43 publications

Heterochromatin re-organization associated with the transcriptional reprogramming under viral infection inArabidopsis

Heterochromatin re-organization associated with the transcriptional reprogramming under viral infection inArabidopsis

Transcriptional reprogramming in the entomopathogenic fungus Metarhizium brunneum and its aphid host Myzus persicae during the switch between saprophytic and parasitic lifestyles

An epigenetic change in a moth is generated by temperature and transmitted to many subsequent generations mediated by RNA

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