Extramammary Paget's disease of the hard palate: A case report and review of the literature

Extramammary Paget disease of the buccal mucosa in an elderly patient

“…[4][5][6]9 One of the other four cases without invasive carcinoma had an in situ adenocarcinoma of the minor salivary gland. 10 The three remaining cases, including our case, did not present with an associated underlying malignancy. 7,8 Of the eight reported oral EMPDs, five were in men and three in women.…”

“…4 To date, only eight cases of EMPD involving oral mucosa, including the current case, have been reported in the English literature. [4][5][6][7][8][9][10] Like its mammary counterpart, oral EMPD may arise in association with invasive and/or in situ salivary neoplasia. Four cases of oral EMPD had an underlying salivary carcinoma, which were described as anaplastic adenocarcinoma, undifferentiated carcinoma, salivary duct carcinoma and adenocarcinoma.…”

“…The age ranged from 42 to 86 years. [4][5][6][7][8][9][10] Among the four non-invasive cases, three were localised lesions involving the hard palate/gingiva, hard palate and buccal mucosa, and the other case was widespread with the involvement of bilateral buccal mucosa, palate mucosa, lower lip mucosa and perioral skin. 7,8,10 The four cases with underlying carcinoma were often widespread.…”

“…[4][5][6][7][8][9][10] Among the four non-invasive cases, three were localised lesions involving the hard palate/gingiva, hard palate and buccal mucosa, and the other case was widespread with the involvement of bilateral buccal mucosa, palate mucosa, lower lip mucosa and perioral skin. 7,8,10 The four cases with underlying carcinoma were often widespread. As noted in cutaneous EMPDs, clinical manifestations of oral EMPDs were variable and can mimic inflammatory conditions or oral potentially malignant disorders, such as erosive lichen planus, oral lichenoid lesion, postradiation stomatitis and erythroplakia.…”

“…As noted in cutaneous EMPDs, clinical manifestations of oral EMPDs were variable and can mimic inflammatory conditions or oral potentially malignant disorders, such as erosive lichen planus, oral lichenoid lesion, postradiation stomatitis and erythroplakia. [4][5][6][7][8][9][10] The main histological differential diagnoses include oral epithelial dysplasia and melanoma in situ. The atypical keratinocytes in oral epithelial dysplasia characteristically express p63 and cytokeratin 5/6 with negative staining for cytokeratin 7, whilst the tumour cells in EMPD stain conversely.…”