Sirolimus-Loaded Intravitreal Implant for Effective Treatment of Experimental Uveitis

Paiva, Mayara Rodrigues Brandão de; Vasconcelos-Santos, Daniel Vítor; Vieira, Lorena Carla; Fialho, Sílvia Ligório; Silva-Cunha, Armando

doi:10.1208/s12249-020-01898-4

Cited by 5 publications

(5 citation statements)

References 42 publications

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“…Otherwise, NAG is present in activated macrophages, either resident or infiltrated after inflammation, playing an important role in uveitis as an effector of innate and acquired immunity. NAG levels in naïve animals may be due to the presence of activated resident macrophages [ 11 , 17 , 19 ]. The reduction in the concentration of all biomarkers over time, mainly on day 15, is possibly due to their short half-life, as reported by Paiva et al, who showed high concentrations of IL-6 and TNF-α 2 days after uveitis induction with BCG, and a significant reduction from the 3rd to the 14th day [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…The remaining pellets were used to characterize the inflammatory infiltrate, measuring the activity of N-acetylglucosaminidase (NAG) and myeloperoxidase (MPO) present in macrophages and neutrophils, respectively. The assays were carried out according to the method described by Paiva et al [ 17 ]. For this, pellets were homogenized using a trisodium phosphate buffer solution (0.1 M NaCl, 0.02 M Na 3 PO 4 , and 0.015 M Na 2 EDTA; pH 4.7) and centrifuged at 4 °C for 10 min at 10,000 RPM.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy and Safety Evaluation of Mometasone Furoate in Treating Ocular Inflammation

et al. 2023

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Mometasone furoate (MF) is a medium-potency synthetic glucocorticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. However, its role in the treatment of ocular inflammation has not yet been explored. This work investigated the anti-inflammatory activity of MF in ocular tissues. First, the in vivo safety of the intravitreal (IVT) injection of MF (80, 160, and 240 µg) was evaluated via clinical examination (including the assessment of intraocular pressure), electroretinography (ERG), and histopathology. Second, MF was tested in an experimental model of bacillus Calmette–Guérin (BCG)-induced uveitis in Wistar rats. Intraocular inflammation was then evaluated via a slit-lamp and fundus examination, ERG, histopathology, and the quantification of pro-inflammatory markers. Intravitreal MF showed no toxicity in all the investigated doses, with 160 µg leading to attenuated disease progression and improvement in clinical, morphological, and functional parameters. There was a significant reduction in the levels of inflammatory markers (myeloperoxidase, interleukins 6 and 1β, CXCL-1, and tumor necrosis factor-alpha) when compared to the levels in untreated animals. Therefore, MF should be further investigated as a promising drug for the treatment of ocular inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Efficacy and Safety Evaluation of Mometasone Furoate in Treating Ocular Inflammation

et al. 2023

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“…This customization considers the drug’s properties and the microenvironment of the target ocular tissue. The key features are briefly summarized in Table 2 [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Overview Of the Biodegradable Nano-based Drug Delivery Syste...mentioning

confidence: 99%

“…Through clinical and histopathological exams after 35 days, the treated eyes with implants revealed less severe inflammation and reduced damage in cell infiltration in the anterior and posterior portions of the eye while preserving the integrity of blood-ocular barriers. Based on these findings and due to the lack of signs of cataracts, hemorrhage, or other signs of toxicity, the SRL-PLGA implant was deemed to be a safe and promising future treatment for non-infectious uveitis [ 23 ].…”

Section: Biodegradable Nano-based Dds For Uveitismentioning

confidence: 99%

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A New Era in Ocular Therapeutics: Advanced Drug Delivery Systems for Uveitis and Neuro-Ophthalmologic Conditions

Tan

Akbar

et al. 2023

Pharmaceutics

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The eye’s intricate anatomical barriers pose significant challenges to the penetration, residence time, and bioavailability of topically applied medications, particularly in managing uveitis and neuro-ophthalmologic conditions. Addressing this issue, polymeric nano-based drug delivery systems (DDS) have surfaced as a promising solution. These systems enhance drug bioavailability in hard-to-reach target tissues, extend residence time within ocular tissues, and utilize biodegradable and nanosized polymers to reduce undesirable side effects. Thus, they have stimulated substantial interest in crafting innovative treatments for uveitis and neuro-ophthalmologic diseases. This review provides a comprehensive exploration of polymeric nano-based DDS used for managing these conditions. We discuss the present therapeutic hurdles posed by these diseases and explore the potential role of various biopolymers in broadening our treatment repertoire. Our study incorporates a detailed literature review of preclinical and clinical studies from 2017 to 2023. Owing to advancements in polymer science, ocular DDS has made rapid strides, showing tremendous potential to revolutionize the treatment of patients with uveitis and neuro-ophthalmologic disorders.

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PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry

Wachowiak

Danède

willart

et al. 2023

Journal of Drug Delivery Science and Technology

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Sirolimus-Loaded Intravitreal Implant for Effective Treatment of Experimental Uveitis

Cited by 5 publications

References 42 publications

Efficacy and Safety Evaluation of Mometasone Furoate in Treating Ocular Inflammation

Efficacy and Safety Evaluation of Mometasone Furoate in Treating Ocular Inflammation

A New Era in Ocular Therapeutics: Advanced Drug Delivery Systems for Uveitis and Neuro-Ophthalmologic Conditions

PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry

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