The prognostic significance of metastatic pattern in stage IV male breast cancer at initial diagnosis: a population-based study

Leone, José Pablo; Leone, Bernardo Amadeo; Zwenger, Ariel Osvaldo; Vallejo, Carlos; Romero, A; Machiavelli, M; Pérez, J. Eduardo; Leone, Julieta

doi:10.1007/s10549-020-06052-z

Cited by 9 publications

(9 citation statements)

References 25 publications

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“…In addition to that, many studies have demonstrated that the male gender is an independent risk factor for a shorter survival rate in BMs patients. The conclusion of the study was that middle-aged females had an increased risk of developing BMs, whereas middle-aged males with BMs had an increased risk of poor survival, an aspect underlined also by Leone [ 33 ] and Singh [ 34 ].…”

Section: Resultsmentioning

confidence: 93%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

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Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: (a) breast/chest radiation exposure, (b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and (c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and (d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. Randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.

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Section: Resultsmentioning

confidence: 93%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

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“…During the past years, a lot of research has been done on determining the risk factors for lymph node involvement and survival in patients with different subtypes of breast cancer or coexisting with distant metastasis at initial diagnosis [13,[15][16][17][18][19]. As IDC and invasive lobular carcinoma (ILC) accounted for the vast majority of cases, the clinicopathological characteristics of these two types of breast cancer were the main object of intensive research.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Wang et al established a nomogram for predicting the prognosis of female patients with breast cancer and bone metastasis at presentation [19] and Cui et al [15] established a nomogram for predicting the LNM in TNBC patients. On the contrary, PMBC, as a rare histologic type of mammary neoplasm, accounting for 1-4% of all breast cancers, has rarely been investigated and usually was classified as "others" group in several studies [14,16,19,20]. Recently, increasing attention has been paid to the treatment modalities, especially the necessity of adjuvant chemotherapy, radiotherapy, and anti-HER2 therapy for this kind of malignancy [21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Identifying Clinicopathological Risk Factors of the Regional Lymph Node Metastasis in Patients with T1-2 Mucinous Breast Cancer: A Population-Based Study

Min

Wei

Chen

et al. 2021

Journal of Oncology

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Background. Pure mucinous breast cancer (PMBC) has a better prognosis than other types of invasive breast cancer. However, regional lymph node metastasis (LNM) might reverse this outcome. We aim to determine the independent predictive factors for regional LNM and further develop a nomogram model for clinical practice. Method. Data of PMBC patients from the Surveillance, Epidemiology, and End Results (SEER) program between Jan 2010 and Dec 2015 were retrospectively reviewed. Univariate and multivariate logistic regression analyses were used to determine the risk factors for LNM in T1-2 MBC. The nomogram was constructed and further evaluated by an internal validation cohort. The receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curves were performed to evaluate the accuracy of this model. Result. Five variables, including age, race, tumor size, grade, and breast subtype, were identified to be significantly associated with regional LNM in female patients with T1-2 PMBC. A nomogram was successfully established with a favorable concordance index (C-index) of 0.780, supported by an internal validation cohort with a C-index of 0.767. Conclusion. A nomogram for predicting regional LNM in female patients with T1-2 PMBC was successfully established and validated via an internal cohort. This visualized model would assist surgeons to make appropriate clinical decisions in the management of primary PMBC, especially in terms of whether axillary lymph node dissection (ALND) is warranted.

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“…Przerzuty MBC do OUN są rzadkie, mogą manifestować się 29 jednak nagłym początkiem i szybką progresją objawów, takich jak pogorszenie poziomu świadomości czy nadciśnienie wewnątrzczaszkowe [14]. Sugeruje się, iż płeć męska jest niezależnym czynnikiem ryzyka gorszego rokowania oraz krótszych współczynników przeżycia w przypadku obecności przerzutów do OUN [15]. Autorzy badań nad MBC podkreślają również konieczność zachowania czujności w przypadku pojawienia się nietypowych zmian chorobowych u pacjentów z dodatnim wywiadem onkologicznym.…”

Section: Diagnostykaunclassified

Male breast cancer - a review on risk factors, tumor characteristics, diagnostics and treatment

Zielińska

Aleksandrowicz

Zarankiewicz

et al. 2022

J Educ Health Sport

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Introduction and purpose: Male breast cancer (MBC) is estimated to less than 1% of all breast cancer cases worldwide. A lifetime risk of developing MBC amounts to 1:1000. The data on breast cancer in men is limited. This review aims to analyze information on risk factors, diagnostics and treatment in men suffering from breast cancer. Material and method: This review was based on available data collected in PubMed and published in the years 2001-2022. The research was done by looking through keywords as follows: “breast cancer”, “male breast cancer”, “risk factors” and “treatment”. Results: Male breast cancer usually manifests as a painless, retroareolar mass in the breast. Risk factors include advanced age, hormonal imbalance, exposure to radiation and a positive family history. A significant risk increase in MBC development occurs in BRCA2, CHEK2, PALB2 and ATM genes mutations. G2 ductal carcinoma with no special type is most often diagnosed. Dominating subtype is luminal A cancer, while HER2 protein overexpression is extremely rare. Radical mastectomy or breast conserving therapy remain surgical therapeutic options. The most preferred endocrine therapy is tamoxifen. The choice of chemotherapy in men is based on the same criteria as in women. Conclusions: Delayed diagnosis and tumor characteristics are associated with a much worse prognosis for men compared to women. Therefore, further clinical research is crucial in order to improve the diagnostic possibilities and treatment targeted at men with this type of cancer.

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The prognostic significance of metastatic pattern in stage IV male breast cancer at initial diagnosis: a population-based study

Cited by 9 publications

References 25 publications

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

Identifying Clinicopathological Risk Factors of the Regional Lymph Node Metastasis in Patients with T1-2 Mucinous Breast Cancer: A Population-Based Study

Male breast cancer - a review on risk factors, tumor characteristics, diagnostics and treatment

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