Incomplete mitophagy in the mevalonate kinase-deficient Saccharomyces cerevisiae and its relation to the MKD-related autoinflammatory disease in humans

Santos, Manuella Maria Silva; Gatica, Damián; Silva, Jaqueline de Azevêdo; Crovella, Sérgio; Klionsky, Daniel J.; Morais, Marcos Antônio de

doi:10.1016/j.bbadis.2020.166053

Cited by 1 publication

(2 citation statements)

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“…These processes are not completed; therefore, damaged mitochondria may not be recycled and may generate cellular metabolic dysfunction. Understanding this mechanism may help researchers decipher the nonspecific autoinflammatory response observed in patients with MKD [ 111 , 112 ].…”

Section: Yeast Saccharomyces Cerevisiae Could Be Used To Express Human Proteinsmentioning

confidence: 99%

“…More recently, it has been shown that mitophagy during prolonged respiratory growth is strongly impaired in yeast cells lacking Get1/2, a transmembrane complex mediating the insertion of tail-anchored (TA) proteins into the ER membrane [ 123 ]. The connection between ER and mitochondria also could be made through this Get1/2 complex and the complex FAR that Dr. Kanki’s team highlighted [ 56 , 112 ]. We must now understand how these two complexes interact and the mechanisms involved in regulating mitophagy through the key protein Atg32.…”

Section: Future Directionsmentioning

confidence: 99%

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Mitophagy in Yeast: Decades of Research

Bhatia‐Kiššová

Camougrand

2021

Cells

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Mitophagy, the selective degradation of mitochondria by autophagy, is one of the most important mechanisms of mitochondrial quality control, and its proper functioning is essential for cellular homeostasis. In this review, we describe the most important milestones achieved during almost 2 decades of research on yeasts, which shed light on the molecular mechanisms, regulation, and role of the Atg32 receptor in this process. We analyze the role of ROS in mitophagy and discuss the physiological roles of mitophagy in unicellular organisms, such as yeast; these roles are very different from those in mammals. Additionally, we discuss some of the different tools available for studying mitophagy.

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Section: Yeast Saccharomyces Cerevisiae Could Be Used To Express Human Proteinsmentioning

confidence: 99%