Bisphenol A and six other environmental phenols in urine of children and adolescents in Germany – human biomonitoring results of the German Environmental Survey 2014–2017 (GerES V)

Tschersich, Carolin; Murawski, Aline; Schwedler, Gerda; Rucic, Enrico; Moos, Rebecca K.; Kasper-Sonnenberg, Monika; Koch, Holger M.; Brüning, Thomas; Kolossa-Gehring, Marike

doi:10.1016/j.scitotenv.2020.144615

Cited by 60 publications

(32 citation statements)

References 34 publications

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“…They show that 40% of urine samples contained detectable quantity of BPA, but also we found BPAF (5%) and BPF (1.3%) in different samples. These results are in concordance with other studies concerning BPs in children urine; some of them detected BPA in remarkable concentrations and even established an association between BPA level in urine and body mass index (Tschersich et al, 2021 ; Mahfouz et al, 2021 ).…”

Section: Description Of Work Programmesupporting

confidence: 93%

Association between dietary exposure to bisphenols and body mass index in Spanish schoolchildren

Stecca

Moscoso-Ruiz

Gálvez-Ontiveros

et al. 2022

EFS2

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The increase in children obesity worldwide has been of particular concern in recent decades. Environmental factors have been proposed as contributors to obesity, and there is a growing concern over obesogens, environmental chemicals with potential obesity‐related endocrine‐disrupting properties. In this regard, bisphenol A (BPA) and its analogues are suspected to have obesogenic properties. Current document report on the activities of the fellow, undertaken during the fourth, 2020–2021 cycle of the EU‐FORA programme at the University of Granada, Institute of Nutrition and Food Science, in Spain. The work programme offered by the hosting site was related to the extrapolation of bisphenols exposure following the determination of these compounds in food frequently consumed by children and in their biological samples. The fellow has participated in the recruitment of the study population in the health centres. In addition, she has participated in the collection of the children biological samples, anthropometric measurements and dietary surveys and in the optimisation of the laboratory methodology for the extraction of bisphenols in biological samples. All these activities also provided the fellow an opportunity to develop her data science related skills, which will benefit her professional development. In addition, the fellow gained an overview of various topics related to food safety risk assessment by attending the EU‐FORA dedicated training modules.

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Section: Description Of Work Programmesupporting

confidence: 93%

Association between dietary exposure to bisphenols and body mass index in Spanish schoolchildren

Stecca

Moscoso-Ruiz

Gálvez-Ontiveros

et al. 2022

EFS2

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“…Taking into account the HBM-GV GenPop developed, and the internal exposure measured in the Esteban study, the RCRs obtained with the P95 are greater than 1 for all age groups ( Table 4 ) [ 42 ]. Therefore, the health risk associated with exposure to BPS cannot be excluded.…”

Section: Resultsmentioning

confidence: 99%

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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Within the European Joint Programme HBM4EU, Human Biomonitoring Guidance Values (HBM-GVs) were derived for several prioritised substances. In this paper, the derivation of HBM-GVs for the general population (HBM-GVGenPop) and workers (HBM-GVworker) referring to bisphenol S (BPS) is presented. For the general population, this resulted in an estimation of the total urinary concentration of BPS of 1.0 µg/L assuming a 24 h continuous exposure to BPS. For workers, the modelling was refined in order to reflect continuous exposure during the working day, leading to a total urinary concentration of BPS of 3.0 µg/L. The usefulness for risk assessment of the HBM-GVs derived for BPS and bisphenol A (BPA) is illustrated. Risk Characterisation Ratios (RCRs) were calculated leading to a clear difference between risk assessments performed for both bisphenols, with a very low RCR regarding exposure to BPA., contrary to that obtained for BPS. This may be due to the endocrine mediated endpoints selected to derive the HBM-GVs for BPS, whereas the values calculated for BPA are based on the temporary Tolerable Daily Intake (t-TDI) from EFSA set in 2015. A comparison with the revised TDI recently opened for comments by EFSA is also discussed. Regarding the occupational field, results indicate that the risk from occupational exposure to both bisphenols cannot be disregarded.

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“…Both cell lines were exposed to six MDCs, namely Bisphenol A (BPA), Tributyltin (TBT), Perfluorooctanoic acid (PFOA), Triphenylphosphate (TPP), Triclosan (TCS), and Dichlorodiphenyldichloroethylene (DDE). The concentration range tested herein was based on biomonitoring studies for BPA [15], TBT [16], PFOA [17], TPP [18], TCS [19] and DDE [20]. BPA and TBT have been previously tested in β-cells.…”

Section: Introductionmentioning

confidence: 99%

Development of in vitro test methods in a model of human pancreatic β-cells to identify metabolism disrupting chemicals with diabetogenic activity

Santos

Medina-Gali

Babiloni-Chust

et al. 2022

Preprint

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There is a need to develop identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity. Here we used the human EndoC-βH1 β-cell line, the rat β-cell line INS-1E and dispersed mouse islet cells to assess the effects of endocrine disruptors on cell viability and glucose-stimulated insulin secretion (GSIS). We tested six chemicals at concentrations within human exposure (from 0.1 pM to 1 μM). Bisphenol-A (BPA) and tributyltin (TBT) were used as controls while four other chemicals, namely perfluorooctanoic acid (PFOA), triphenylphosphate (TPP), triclosan (TCS) and dichlorodiphenyldichloroethylene (DDE), were used as “unknowns”. Regarding cell viability, BPA and TBT increased cell death as previously observed. Their mode of action involved the activation of estrogen receptors and PPARγ, respectively. ROS production was a consistent key event in BPA- and TBT-treated cells. None of the other MDCs tested modified viability or ROS production. Concerning GSIS, TBT increased insulin secretion while BPA produced no effects. PFOA decreased GSIS, suggesting that this chemical could be a “new” diabetogenic agent. Our results indicate that the EndoC-βH1 cell line is a suitable human β-cell model for testing diabetogenic MDCs. Optimization of the test methods proposed here could be incorporated into tier protocols for the identification of MDCs.

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Bisphenol A and six other environmental phenols in urine of children and adolescents in Germany – human biomonitoring results of the German Environmental Survey 2014–2017 (GerES V)

Cited by 60 publications

References 34 publications

Association between dietary exposure to bisphenols and body mass index in Spanish schoolchildren

Association between dietary exposure to bisphenols and body mass index in Spanish schoolchildren

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Development of in vitro test methods in a model of human pancreatic β-cells to identify metabolism disrupting chemicals with diabetogenic activity

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