Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities

Hu, Shuiyao; Chai, Wern Chern; Xu, Lin-Tao; Li, Shaoqiang; Jin, Cuirong; Zhu, Rongxiu; Yang, Lei; Zhang, Ranran; Tang, Kai-Jun; Li, Ping; Yang, Erlan; Chang, Wenqiang; Shen, Tao; Semple, Susan J.; Venter, Henrietta; Xiang, Lan

doi:10.1016/j.phytochem.2020.112587

Cited by 11 publications

(15 citation statements)

References 36 publications

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“…The presence of noradrenaline and dopamine in purslane is further confirmed by several other studies [16,129,130]. Hu et al [131] identified 22 compounds from a water extract of purslane and nine of them were found to be catecholamine derivatives. Martins et al [132] have demonstrated neuroprotective effect of purslane in wistar rats.…”

Section: Catecholamines (Cas)supporting

confidence: 57%

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A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)

Kumar

Sreedharan

Kashyap³

et al. 2022

Heliyon

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The Portulaca oleracea L. commonly known as purslane is distributed all over the world and easily grows in diverse soil and climatic conditions. It has been traditionally used as a nutritious and ethnomedicinal food across the globe. Various studies have shown that the plant is a rich source of various important phytochemicals such as flavonoids, alkaloids, terpenoids, proteins, carbohydrates, and vitamins such as A, C, E, and B, carotenoids and minerals such as phosphorus, calcium, magnesium and zinc. It is particularly very important because of the presence of a very high concentration of omega-3- fatty acids especially α-linolenic acid, gamma-linolenic acid and linoleic acid, which are not generally synthesized in terrestrial plants. Various parts of purslane are known for ethnomedicinal and pharmacological uses because of its anti-inflammatory, antidiabetic, skeletal muscle relaxant, antitumor, hepatoprotective, anticancer, antioxidant, anti-insomnia, analgesic, gastroprotective, neuroprotective, wound healing and antiseptic activities. Due to multiple benefits of purslane, it has become an important wonder crop and various scientists across the globe have shown much interest in it as a healthy food for the future. In this review, we provide an update on the phytochemical and nutritional composition of purslane, its usage as nutritional and an ethnomedicinal plant across the world. We further provide a detailed account on ethnopharmacological studies that have proved the ethnomedicinal properties of purslane.

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Section: Catecholamines (Cas)supporting

confidence: 57%

“…Hu et al. [ 131 ] identified 22 compounds from a water extract of purslane and nine of them were found to be catecholamine derivatives. Martins et al.…”

Section: Diverse Metabolites Belonging To Different Classes Of Specialised Metabolites Reported In Purslane and Their Individual Bioactivmentioning

confidence: 99%

A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)

Kumar

Sreedharan

Kashyap³

et al. 2022

Heliyon

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“…The sources of herbal medicine and the tested bacterial strains were very different, and these factors might be the main causes of the different MIC results. Moreover, some compounds identified from P. oleracea exhibited only weak dose-dependent inhibition against bacterial pathogens, whereas other compounds showed significant antibacterial activity against common enteropathogenic bacteria in vitro ( Lei et al, 2015 ; Hu et al, 2021 ). Interestingly, two unsaturated fatty acids from P. oleracea acted synergistically with erythromycin in vitro against MRSA, possibly by inhibiting the multidrug efflux pump of the bacteria ( Chan et al, 2015 ; Fung et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Portulaca oleracea L. organic acid extract inhibits persistent methicillin-resistant Staphylococcus aureus in vitro and in vivo

Liu

Yang

et al. 2023

Front. Microbiol.

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Staphylococcus aureus continues to be one of the most important pathogens capable of causing a wide range of infections in different sites of the body in humans and livestock. With the emergence of methicillin-resistant strains and the introduction of strict laws on antibiotic usage in animals, antibiotic replacement therapy has become increasingly popular. Previous studies have shown that Portulaca oleracea L. extract exerts a certain degree of bacteriostatic effect, although the active ingredients are unknown. In the present study, the antibacterial activity of the organic acid of P. oleracea (OAPO) against S. aureus was examined using a series of experiments, including the minimum inhibitory concentration, growth curve, and bacteriostasis curve. In vitro antibacterial mechanisms were evaluated based on the integrity and permeability of the cell wall and membrane, scanning electron microscopy, and soluble protein content. A mouse skin wound recovery model was used to verify the antibacterial effects of OAPO on S. aureus in vivo. The results showed that OAPO not only improved skin wound recovery but also decreased the bacterial load in skin wounds. Moreover, the number of inflammatory cells and cytokines decreased in the OAPO-treated groups. In summary, this study reports a botanical extract that can inhibit S. aureus in vitro and in vivo, indicating the potential use of OAPO to prevent and control S. aureus infection in the near future.

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“…One of the areas in East Java, precisely in Wonosalam Village, Wonosalam District, Jombang Regency, owns a type of purslane plant (Portulaca oleracea) which is commonly found on rice fields, sidewalks, or on the edge of highways. The perspective of general public still considers that purslane is just only weed for the cultivation of other productive crops [1], [2]. Only a few of them are familiar with this weed that can be consumed as either fresh or cooked, and some use it as herbal medicine [3], [4].…”

Section: Introductionmentioning

confidence: 99%

“…Several recent studies have shown several advantages of purslane plant in the field of medicine known as a perennial plant [11] which can be used as an anti-inflammatory [1], [3], [12] anticancer [13], anti-virus (on viruses of the coronaviridae group) [5]; anti-melanogenic [6], producing anticholinesterase-effect [2], [14], [15] and immunomodulatory regulation [16]. Several recent studies have shown several advantages of purslane plant in the field of medicine known as a perennial plant 11 which can be used as an anti-inflammatory [1], [3], [12], anticancer [13], anti-virus (on viruses of the coronaviridae group) [5]; anti-melanogenic [6], producing anticholinerase-effect [2], [14]- [15], and immunodulatory regulation [16].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Characteristics of Various Dimsum Fortified with Purslane Leaves

Mushollaeni

Tantalu

Ghofur

2022

EJFOOD

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(One of the villages with abundant natural resources is Wonosalam Village in Jombang, East Java. One of the potentials is purslane (Portulaca oleracea) but underutilized yet and just known as a wild plant or weed. The availability of pursiane plants reaches 5-8 quintals/month from each population plot. However, this plant will be discarded because it interferes with the growth of economically valuable plants. Whereas according to research, purslane plants contain lots of phenolic bioactive compounds, flavonoids, carotenoids, and essential fatty acids that are useful as antioxidants and disease prevention. Therefore, this experiment aimed to obtain the best composition of various processed dimsum fortified using purslane leaves. This study used a randomized block design with various formulations of dimsum fortified using purslane leaves, namely purslane dumpling (SK), fantasy purslane dumpling (SKF), purslane drew-dumpling (DK) and purslane manti (KM) the results showed that pursiane dumplings were the best treatment, with physico-chemical parameters of protein, fat, water, ash, and carbohydrate content of 14.10%; 5.4%; 50.54%; 2.37%; and 21.8%. All kinds of dimsum fortified with purslane leaves contain unsaturated fatty acids from the medium-chain fatty acid (MCFAs) and polyunsaturated fatty acids (PUFAs) group.

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Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities

Cited by 11 publications

References 36 publications

A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)

A review on bioactive phytochemicals and ethnopharmacological potential of purslane (Portulaca oleracea L.)

Portulaca oleracea L. organic acid extract inhibits persistent methicillin-resistant Staphylococcus aureus in vitro and in vivo

Phytochemical Characteristics of Various Dimsum Fortified with Purslane Leaves

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