Nerve growth factor protects salivary glands from irradiation-induced damage

Li, Shen-sui; Wu, Chenzhou; Zhang, Bowen; Qiu, Ling; Chen, Wen; Yuan, Yihang; Liu, Xing-chen; Li, Chunjie; Li, Longjiang

doi:10.1016/j.lfs.2020.118748

Cited by 11 publications

(6 citation statements)

References 27 publications

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“…This process is achieved by the dephosphorylation of JNK kinase. It is not achieved by dephosphorylating JNK kinase instead of promoting AKT phosphorylation [ 161 ]. Researchers previously conducted a phase I human clinical trial in which the adenovirus gene AQP1 was transferred to a single SG of xerostomia caused by IR.…”

Section: Treatment Of Risgimentioning

confidence: 99%

Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress

et al. 2021

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Radiation therapy is a common treatment for head and neck cancers. However, because of the presence of nerve structures (brain stem, spinal cord, and brachial plexus), salivary glands (SGs), mucous membranes, and swallowing muscles in the head and neck regions, radiotherapy inevitably causes damage to these normal tissues. Among them, SG injury is a serious adverse event, and its clinical manifestations include changes in taste, difficulty chewing and swallowing, oral infections, and dental caries. These clinical symptoms seriously reduce a patient’s quality of life. Therefore, it is important to clarify the mechanism of SG injury caused by radiotherapy. Although the mechanism of radiation-induced SG injury has not yet been determined, recent studies have shown that the mechanisms of calcium signaling, microvascular injury, cellular senescence, and apoptosis are closely related to oxidative stress. In this article, we review the mechanism by which radiotherapy causes oxidative stress and damages the SGs. In addition, we discuss effective methods to prevent and treat radiation-induced SG damage.

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Section: Treatment Of Risgimentioning

confidence: 99%

Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress

et al. 2021

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“…microRNA-92b is a marker for predicting the response to TPF induction chemotherapy and evaluating the prognosis of patients with advanced OSCC [30]. In addition, in our previous studies, the expression of stromal cell derived factor-1 and nerve growth factor (NGF) was up-regulated in the tumor stage of TNM, while NGF protected salivary glands from radiotherapy damage [31]. Further studies should focus on this topic and explore the mechanism of stromal cells-derived factor-1 pathway in induction chemotherapy and the roles of physiological and biochemical indexes in the prognosis of TPF chemotherapy.…”

Section: Discussionmentioning

confidence: 94%

Neoadjuvant Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma: A Single Center Study

weili²,

Tian³

et al. 2022

Preprint

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Objective:Aimed to evaluate the effect and response from the adjuvant chemotherapy for locally advanced oral squamous cell carcinoma. Methods: Retrospectively collected 46 patients with local late oral squamous cell carcinoma admitted from 2017 to 2021. The patients were treated with TPF induction chemotherapy. All patients completed at least 2 cycle of TPF (PF) regimen (75 mg / m2 of docetaxel on day 1 + 75 mg / M2 of cisplatin on day 1 + 750 mg / m2 of 5-fluorouracil on days 1 ~ 5, one cycle every 21 days), The primary end-points were overall response rate, safety of therapy and overall survival were evaluated. Results: After two cycles of TPF treatment, patients continued receiving surgery followed by radiotherapy or chemotherapy, include 5 patients were received PF. The complete remission rate was 6.25% (2/32), and the objective remission rate was 71.88% (23/32). Most of the adverse factors of chemotherapy response are alleviated. The median follow-up time was 26 months, and the median OS was 25.51 ± 3.81 months. Conclusion: Neoadjuvant chemotherapy, such as TPF or PF, plays an important role in the comprehensive treatment of advanced OSCC and postoperative assessments of white blood cell can provide high-quality prognostic information.

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“…The MAPK subfamily, concluding three major subfamilies, P38, JNK, and ERK, mediate inflammatory induced signal transduction pathways [51]. The NF-κB pathway regulates genes involved in immune and inflammatory processes and its activation could accelerate the release of pro-inflammatory cytokines leading to tissue damage ultimately [52]. In the present study, we observed the expression of MAPK and NF-κB significantly downregulated in CUG piglets compared with NCUG piglets, which further indicates that CUG piglets have lower levels of intestinal inflammation.…”

Section: Discussionmentioning

confidence: 99%

Restored intestinal integrity, nutrients transporters, energy metabolism, antioxidative capacity and decreased harmful microbiota were associated with IUGR piglet's catch-up growth before weanling

Cui

Wang

et al. 2022

J Animal Sci Biotechnol

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Background Intrauterine growth restriction (IUGR) is a major inducer of higher morbidity and mortality in the pig industry and catch-up growth (CUG) before weanling could significantly restore this negative influence. But there was limited knowledge about the underlying mechanism of CUG occurrence. Methods Eighty litters of newborn piglets were divided into normal birth weight (NBW) and IUGR groups according to birth weight. At 26 d, those piglets with IUGR but over average body weight of eighty litters of weaned piglets were considered as CUG, and the piglets with IUGR still below average body weight were considered as NCUG. This study was conducted to systemically compare the intestinal difference among NBW, CUG and NCUG weaned piglets considering the crucial role of the intestine for piglet growth. Results The results indicated that the mRNA expression of nutrients (amino acids, glucose, and fatty acids) transporters, and mitochondrial electron transport chain (ETC) I were upregulated in CUG piglets’ gut with improved morphology compared with those NCUG, as well as the ratio of P-AMPK/AMPK protein expression which is the indicator of energy metabolism. Meanwhile, CUG piglet’s gut showed higher antioxidative capacity with increased SOD and GSH-Px activity, decreased MDA levels, as well as higher mRNA expressions of Nrf2, Keap1, SOD, and GSH-Px. Furthermore, inflammatory parameters including TNF-α, IL-1β, IL-6, and IL-12 factors, and the activation of MAPK and NF-κB signaling pathways were significantly elevated in the NCUG intestine, while the protein expression of ZO-1, Occludin and Claudin-1 was reduced. The alpha diversity of fecal microbiota was higher in CUG piglets in contrast with NCUG piglets, and the increased beneficial bacteria and decreased pathogenic bacteria was also observed in CUG piglets. Conclusions CUG piglet’s intestine showed comprehensive restoration including higher nutrients transport, energy metabolism, antioxidant capacity, and intestinal physical barrier, while lower oxidative stress, inflammatory response, and pathogenic microbiota.

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Nerve growth factor protects salivary glands from irradiation-induced damage

Cited by 11 publications

References 27 publications

Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress

Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress

Neoadjuvant Chemotherapy for Locally Advanced Oral Squamous Cell Carcinoma: A Single Center Study

Restored intestinal integrity, nutrients transporters, energy metabolism, antioxidative capacity and decreased harmful microbiota were associated with IUGR piglet's catch-up growth before weanling

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