HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population

Souza-Santana, Fabiana Covolo de; Querino, Gislaine Aparecida; Camargo, Rodrigo Mendes de; Souza, Vânia Niéto Brito de; Mangilli, Priscila Bettoni Ballallai; Mira, Marcelo Távora; Bezerra, Ohanna Cavalcanti de Lima; Kehdy, Fernanda S. G.; Visentainer, Jeane Eliete Laguila; Alves, Hugo Vicentin; Jarduli, Luciana Ribeiro; Moraes, Milton Ozório; Marcos, Elaine Valim Camarinha; Latini, Ana Carla Pereira

doi:10.1016/j.humimm.2020.10.008

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Carriers of this SNP demonstrated 2.12 and 2.74 times greater likelihood of developing leprosy and lepromatous subtypes ( 173 ). HLA-C12, HLA-B15, HLA-C05 was associated with Brazilian patients ( 139 , 174 ). HLA-A, HLA-C and HLA-Cw may associated with the Indian population ( 140 ).…”

Section: Leprosy Is Under Precise Regulation By Genetic Factorsmentioning

confidence: 94%

Leprosy: treatment, prevention, immune response and gene function

Li,

Ma,

et al. 2024

Front. Immunol.

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Since the leprosy cases have fallen dramatically, the incidence of leprosy has remained stable over the past years, indicating that multidrug therapy seems unable to eradicate leprosy. More seriously, the emergence of rifampicin-resistant strains also affects the effectiveness of treatment. Immunoprophylaxis was mainly carried out through vaccination with the BCG but also included vaccines such as LepVax and MiP. Meanwhile, it is well known that the infection and pathogenesis largely depend on the host’s genetic background and immunity, with the onset of the disease being genetically regulated. The immune process heavily influences the clinical course of the disease. However, the impact of immune processes and genetic regulation of leprosy on pathogenesis and immunological levels is largely unknown. Therefore, we summarize the latest research progress in leprosy treatment, prevention, immunity and gene function. The comprehensive research in these areas will help elucidate the pathogenesis of leprosy and provide a basis for developing leprosy elimination strategies.

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Section: Leprosy Is Under Precise Regulation By Genetic Factorsmentioning

confidence: 94%

Leprosy: treatment, prevention, immune response and gene function

Li,

Ma,

et al. 2024

Front. Immunol.

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“…A recent study was conducted to investigate the association of HLA class I and II genes with leprosy in a Brazilian population. The study identified the association of HLA-C ∗ 12 and HLA - DPB1 ∗ 105 with susceptibility to leprosy, while HLA-C ∗ 08 , HLA-DPB1 ∗ 04 , and HLA-DPB1 ∗ 18 were protective against leprosy [ 43 ]. Dallmann-Sauer et al performed next-generation sequencing to genotype three HLA class I and eight class II genes in 1,155 individuals from a Vietnamese leprosy case-control sample.…”

Section: Genetic Association Between Hla Loci and Infectious Diseasesmentioning

confidence: 99%

Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections

Medhasi

Chantratita

2022

Journal of Immunology Research

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The human leukocyte antigen (HLA) system is one of the most crucial host factors influencing disease progression in bacterial and viral infections. This review provides the basic concepts of the structure and function of HLA molecules in humans. Here, we highlight the main findings on the associations between HLA class I and class II alleles and susceptibility to important infectious diseases such as tuberculosis, leprosy, melioidosis, Staphylococcus aureus infection, human immunodeficiency virus infection, coronavirus disease 2019, hepatitis B, and hepatitis C in populations worldwide. Finally, we discuss challenges in HLA typing to predict disease outcomes in clinical implementation. Evaluation of the impact of HLA variants on the outcome of bacterial and viral infections would improve the understanding of pathogenesis and identify those at risk from infectious diseases in distinct populations and may improve the individual treatment.

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“…Additional studies have also shown an association between leprosy and single-nucleotide polymorphisms (SNPs) near HLA genes in leprosy-affected individuals. 21 SNPs are variations in DNA between genes that can act as biomarkers and can help predict susceptibility and risk of developing the disease. GWAS, a novel missense variant in MRPS5, has recently been indicated as a susceptibility locus for leprosy among Chinese subjects.…”

Section: Geneticsmentioning

confidence: 99%

“…Zhang 11 conducted the first genome‐wide association study (GWAS) of leprosy and found a significant genetic association linked to the major histocompatibility complex (MHC). Additional studies have also shown an association between leprosy and single‐nucleotide polymorphisms (SNPs) near HLA genes in leprosy‐affected individuals 21 . SNPs are variations in DNA between genes that can act as biomarkers and can help predict susceptibility and risk of developing the disease.…”

Section: Geneticsmentioning

confidence: 99%

Leprosy: what is new

2021

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Leprosy, also known as Hansen’s disease, is an age‐old chronic granulomatous infection characterized by prominent cutaneous and neurologic findings. Long known to be caused by Mycobacterium leprae, a new etiologic species was identified and linked in 2008, Mycobacterium lepromatosis. The BCG vaccine with highly variable efficacy may soon be replaced by the first leprosy‐specific subunit vaccine LepVax, which has recently moved forward in human trials. Recent evidence supporting theories of zoonotic transmission from armadillos and the less‐discussed Eurasian red squirrels has emerged. Knowledge on genetic polymorphisms that may increase leprosy susceptibility, such as the newly uncovered mitochondrial ribosomal protein S5 (MRPS5) polymorphism in the Chinese population, has provided a fresh perspective and direction. Further, we will delineate the latest information on leprosy, including the possible effects of leprosy coinfection with COVID‐19, HIV, and HTLV‐1, and the shift to newer leprosy therapies and treatment regimens.

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HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population

Cited by 5 publications

References 29 publications

Leprosy: treatment, prevention, immune response and gene function

Leprosy: treatment, prevention, immune response and gene function

Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections

Leprosy: what is new

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