Host genetics influences the relationship between the gut microbiome and psychiatric disorders

Martins‐Silva, Thais; Salatino-Oliveira, Angélica; Genro, Júlia Pasqualini; Meyer, Fernando D.T.; Li, Yan; Rohde, Luís Augusto; Hutz, Mara Helena; Tovo‐Rodrigues, Luciana

doi:10.1016/j.pnpbp.2020.110153

Cited by 23 publications

(15 citation statements)

References 71 publications

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“…Interestingly, there is also growing evidence supporting the role of the human gut microbiome in the development of ADHD (Sampson and Mazmanian, 2015;Boonchooduang et al, 2020). It has been well known that the gut microbiota is the largest ecosystem in the human body, which is believed to play a pivotal role in human health and disease such as psychiatric disorders in multiple ways (Martins-Silva et al, 2021). In practicality, the brain-gut axis theory proposes that the gut microbiota can influence brain function and behaviors through involvement in physiological homoeostasis, immunological development, glutathione metabolism, amino acid metabolism, etc (De Vadder et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children

Zhou

Jiang

et al. 2021

Front. Microbiol.

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Attention-deficit hyperactivity disorder (ADHD) seriously affects children’s health, and the gut microbiome has been widely hypothesized to play a role in the regulation of ADHD behavior. The present study aims to the biosynthesize of zinc oxide nanoparticles (ZnONPs) by using Acinetobacter johnsonii strain RTN1, followed by their characterization through state-of-the-art material characterization techniques, viz., UV–vis spectroscopy, Fourier transform infrared spectroscopy, and transmission and scanning electron microscopic analyses with energy dispersive spectrometry. Moreover, we investigated and compared the population composition of gut microbiota and their susceptibility to biogenic ZnONPs between healthy and ADHD children based on the traditional plate method and 16S rRNA amplicon sequence analysis. The antibacterial effect of ZnONPs against gut bacteria was also determined by measurement of live cell number, living/dead bacterial staining test, and flow cytometry observation. The present study revealed that the number of live gut bacteria in healthy children was more than 10-fold higher than that in ADHD children; however, the community structure of gut bacteria has changed, while greater diversity was found in gut bacteria from ADHD children. In addition, we found that the number of live gut bacteria in healthy and ADHD children was reduced by ZnONPs, which shows an increased and reduced effect in composition of gut bacteria from healthy and ADHD children, respectively. It was also noted that the main mechanism of ZnONPs may be to inhibit the growth of gut bacteria rather than to kill them, while the nanoparticle-resistant strains in healthy children is also different from that in ADHD children. Some representative bacteria, in particular nanoparticle-resistant bacteria, were successfully isolated and identified. Overall, this study revealed the potential correlation of ADHD with gut bacteria and provided a new possibility to prevent ADHD by the combination of nanoparticle and its resistant bacteria.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children

Zhou

Jiang

et al. 2021

Front. Microbiol.

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“…Nevertheless, PICS+CLPP and PICS+fastENLOC associated sets of clusters were enriched with genes associated with processes involving TF regulation as well as inflammation or neurogenesis (Supplementary Tables S10, S11). All these processes are associated with MD pathogenesis (Shadrina et al, 2018;Zhong et al, 2019;Li X. et al, 2021, Li et al, 2021Pérez-Granado et al, 2022). In general, the identified eGenes are poorly characterized yet the cluster analysis shades some light on their potential molecular associations.…”

Section: Discussionmentioning

confidence: 99%

Benchmarking post-GWAS analysis tools in major depression: Challenges and implications

Pérez-Granado

Piñero²,

Furlong³

2022

Front. Genet.

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Our knowledge of complex disorders has increased in the last years thanks to the identification of genetic variants (GVs) significantly associated with disease phenotypes by genome-wide association studies (GWAS). However, we do not understand yet how these GVs functionally impact disease pathogenesis or their underlying biological mechanisms. Among the multiple post-GWAS methods available, fine-mapping and colocalization approaches are commonly used to identify causal GVs, meaning those with a biological effect on the trait, and their functional effects. Despite the variety of post-GWAS tools available, there is no guideline for method eligibility or validity, even though these methods work under different assumptions when accounting for linkage disequilibrium and integrating molecular annotation data. Moreover, there is no benchmarking of the available tools. In this context, we have applied two different fine-mapping and colocalization methods to the same GWAS on major depression (MD) and expression quantitative trait loci (eQTL) datasets. Our goal is to perform a systematic comparison of the results obtained by the different tools. To that end, we have evaluated their results at different levels: fine-mapped and colocalizing GVs, their target genes and tissue specificity according to gene expression information, as well as the biological processes in which they are involved. Our findings highlight the importance of fine-mapping as a key step for subsequent analysis. Notably, the colocalizing variants, altered genes and targeted tissues differed between methods, even regarding their biological implications. This contribution illustrates an important issue in post-GWAS analysis with relevant consequences on the use of GWAS results for elucidation of disease pathobiology, drug target prioritization and biomarker discovery.

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“…Specifically, cytokine and chemokine profiles alteration, which is derived from CCL2 [36], CCL7, and CCL11 [37] imbalance in our patients, may provoke this neurodevelopmental disorder. Furthermore, ASIC2 has been linked with gut microbiome modulation [38], which is nowadays considered responsible for many psychiatric disturbances, including ASD, since it may contribute to inflammation via the gut-brain axis [39]. Autistic regression has recently been related to neuroinflammation [40], as occurred in Patient 11, who had a cessation of language development and a regression of relational abilities after a respiratory infection, and each subsequent inflammatory episode connoted similar functional consequences.…”

Section: Discussionmentioning

confidence: 99%

17q12 Recurrent Deletions and Duplications: Description of a Case Series with Neuropsychiatric Phenotype

Milone

Tancredi

Cosenza

et al. 2021

Genes

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Syndromic neurodevelopmental disorders are usually investigated through genetics technologies, within which array comparative genomic hybridization (Array-CGH) is still considered the first-tier clinical diagnostic test. Among recurrent syndromic imbalances, 17q12 deletions and duplications are characterized by neurodevelopmental disorders associated with visceral developmental disorders, although expressive variability is common. Here we describe a case series of 12 patients with 17q12 chromosomal imbalances, in order to expand the phenotypic characterization of these recurrent syndromes whose diagnosis is often underestimated, especially if only mild traits are present. Gene content and genotype-phenotype correlations have been discussed, with special regard to neuropsychiatric features, whose impact often requires etiologic analysis.

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Host genetics influences the relationship between the gut microbiome and psychiatric disorders

Cited by 23 publications

References 71 publications

Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children

Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children

Benchmarking post-GWAS analysis tools in major depression: Challenges and implications

17q12 Recurrent Deletions and Duplications: Description of a Case Series with Neuropsychiatric Phenotype

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