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Yonker, Lael M.; Neilan, Anne M.; Bartsch, Yannic C.; Patel, Ankit; Regan, James; Arya, Puneeta; Gootkind, Elizabeth; Park, Grace; Hardcastle, Margot; John, Anita St.; Appleman, Lori; Chiu, Michelle L.; Fialkowski, Allison; Flor, Denis De la; Lima, Rosiane; Bordt, Evan A.; Yockey, Laura J.; D’Avino, Paolo; Fischinger, Stephanie; Shui, Jessica E.; Lerou, Paul H.; Bonventre, Joseph V.; Yu, Xu G.; Ryan, Edward T.; Bassett, Ingrid V.; Irimia, Daniel; Edlow, Andrea G.; Alter, Galit; Li, Jonathan Z.; Fasano, Alessio

doi:10.1016/j.jpeds.2020.09.049

Cited by 7 publications

(11 citation statements)

References 6 publications

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“…The differences we observe in first-positive RT-PCR viral load between groups based on age are minor, as in other studies (31)(32)(33)(34)(35) and the viral loads in question, in the range of 5.9 to 6.6 (Table 1), are in a region of the viral load / culture probability association where changes in viral load have relatively little impact on estimated culture probability (Fig. 2C).…”

Section: Estimated Infectiousness In the Youngsupporting

confidence: 62%

Estimating infectiousness throughout SARS-CoV-2 infection course

Jones

Biele

Mühlemann

et al. 2021

Science

439

389

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Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 German SARS-CoV-2 cases, including 6110 from test centres attended by pre-symptomatic, asymptomatic, and mildly-symptomatic (PAMS) subjects, 9519 who were hospitalised, and 1533 B.1.1.7 lineage infections. The youngest had mean log10 viral load 0.5 (or less) lower than older subjects and an estimated ~78% of the peak cell culture replication probability, due in part to smaller swab sizes and unlikely to be clinically relevant. Viral loads above 109 copies per swab were found in 8% of subjects, one-third of whom were PAMS, with mean age 37.6. We estimate 4.3 days from onset of shedding to peak viral load (8.1) and cell culture isolation probability (0.75). B.1.1.7 subjects had mean log10 viral load 1.05 higher than non-B.1.1.7, with estimated cell culture replication probability 2.6 times higher.

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Section: Estimated Infectiousness In the Youngsupporting

confidence: 62%

Estimating infectiousness throughout SARS-CoV-2 infection course

Jones

Biele

Mühlemann

et al. 2021

Science

439

389

View full text Add to dashboard Cite

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“…They reported a correlation with sex that was not con rmed in our sample. Yonker et al [12] reported similar results in children, with those affected with the more severe forms of the disease presenting an increased humoral response.…”

Section: Discussionmentioning

confidence: 72%

“…Studies in SARS-CoV-2-infected patients are still scarce. Yonker et al [12] studied ACE2 expression in infected and healthy children, reporting increased expression in children older than 10 years and in those who had been infected by SARS-CoV-2. In our series, we found a different gradient of expression, with slightly increased expression of ACE2 in children < 18 years of age compared with adults, and increased expression in younger compared with older children.…”

Section: Discussionmentioning

confidence: 99%

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Role of ACE2 And TMPRSS2 Protease In SARS-CoV-2 Dynamics Among Household Contacts of PCR-Confirmed Cases: Impact of A Combined Serological Signature Analysis On Diagnosis

Poch-Páez

Medina

Montesdeoca-Melián

et al. 2021

Preprint

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Background: To examine the hypothesis that ACE2 and TMPRSS2 expression are related to disease susceptibility and severity across age groups and to evaluate the role children play in the household transmission of SARS-CoV-2.Methods: We used a combined serological strategy to confirm past infection in subjects diagnosed with COVID-19 between march 10th and June 2nd 2020 and to evaluate their household members. We also quantified ACE2 and TPMRSS2 expression from saliva. A total of 258 households were included in the study, for a total of 650 volunteers (including 89 children aged under 18 years of age).Results: Our combined testing strategy increased our sensibility by 10%. Antibody indexes decreased with age in children and increased with age in adults. They also increased with disease severity. ACE2 expression was slightly increased in younger children. ACE2 was not related to any other factors. We did not find any relationship between TMPRSS2 expression and any of the studied factors. Children are less frequently infected by SARS-CoV-2 (OR=0,56), they present fewer symptoms and decreased severity. Age and sharing the bedroom with an index case increases the risk of acquiring the infection. The risk in adults increases with age, whereas in children, it increases in younger children. Conclusions: Our results do not support that the level of expression of ACE2 and TMPRSS2 might be related to susceptibility or severity of COVID19 disease. Children have a decreased susceptibility to SARS-CoV-2 infection compared to adults and, when infected, they present less symptoms and a more benign course.

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“…Jika dibandingkan dengan orang dewasa, virus yang terdeteksi pada tinja anak bertahan lebih lama (bisa mencapai 4 minggu). Maka, pengendalian pandemi ini harus lebih memperhatikan lagi kepada anak-anak (Yonker et al, 2020).…”

Section: Pendahuluanunclassified

Efektivitas Edukasi Komik Dan Leaflet Terhadap Peningkatan Pengetahuan Orangtua Siswa Sekolah Dasar Mengenai Phbs Untuk Pencegahan Penularan Virus COVID-19

Rustiarini¹,

Ilmi

Simanungkalit

et al. 2021

JGK

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COVID-19 is currently a major health problem worldwide. Indonesia is one of the countries affected and is in the 21st position with the most positive cases of Covid in the world. Children who are exposed to the Covid-19 virus usually only cause mild symptoms or even cause no symptoms. This makes children a source of spreading the virus without realizing it. Therefore, education on how to prevent the transmission of Covid-19 (Clean and Healthy Living Behavior) is important to prevent children from being exposed to the Covid-19 virus and becoming a source of infection without realizing it. To determine the effect of comic education and leaflets on increasing the knowledge of parents of elementary school students about PHBS for preventing the transmission of the Covid-19 virus. This study used a quasy experimental design with a desaign pre-post test group design involving 68 parents of grade V students who were selected by cluster random sampling. Knowledge data collection is carried out online. There were differences in respondents' knowledge of the effect of comics education media use (p = 0,) and leaflets (p = 0,). There is an effect of nutrition education through comics and leaflets on knowledge about Clean and Healthy Living Behaviors in parents of elementary school students as an effort to prevent the transmission of the Covid-19 virus. ABSTRAK COVID-19 saat ini menjadi masalah kesehatan paling utama di seluruh dunia. Indonesia menjadi salah satu negara yang terdampak dan menduduki posisi ke-21 dengan kasus positif Covid terbanyak di dunia. Anak yang terpapar virus Covid-19 biasanya hanya menimbulkan gejala ringan atau bahkan tidak menimbulkan gejala. Hal ini membuat anak menjadi sumber penyebaran virus tanpa disadari. Oleh sebab itu, edukasi mengenai cara pencegahan penularan Covid-19 (Perilaku Hidup Bersih dan Sehat) penting dilakukan untuk mencegah anak terpapar virus Covid-19 dan menjadi sumber penularan tanpa disadari. Mengetahui efektivitas edukasi komik dan leaflet terhadap peningkatan pengetahuan orangtua siswa sekolah dasar mengenai PHBS untuk pencegahan penularan virus Covid-19. Penelitian ini menggunakan desain quasy experimental dengan rancangan pre-post test group desaign dengan melibatkan 68 orangtua siswa kelas V yang dipilih dengan cluster random sampling. Pengambilan data pengetahuan dilakukan secara daring. Ada perbedaan pengetahuan responden terhadap efektivitas penggunaan media edukasi komik (p=0,) dan leaflet (p=0,). Media komik dan leaflet dapat meningkatkan pengetahuan mengenai Perilaku Hidup Bersih dan Sehat pada orangtua siswa sekolah dasar sebagai upaya pencegahan penularan virus Covid-19. Media leaflet dianggap lebih efektif karena peningkatan rata-rata skornya lebih besar daripada kelompok media komik.

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Cited by 7 publications

References 6 publications

Estimating infectiousness throughout SARS-CoV-2 infection course

Estimating infectiousness throughout SARS-CoV-2 infection course

Role of ACE2 And TMPRSS2 Protease In SARS-CoV-2 Dynamics Among Household Contacts of PCR-Confirmed Cases: Impact of A Combined Serological Signature Analysis On Diagnosis

Efektivitas Edukasi Komik Dan Leaflet Terhadap Peningkatan Pengetahuan Orangtua Siswa Sekolah Dasar Mengenai Phbs Untuk Pencegahan Penularan Virus COVID-19

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