Role of ACE2 And TMPRSS2 Protease In SARS-CoV-2 Dynamics Among Household Contacts of PCR-Confirmed Cases: Impact of A Combined Serological Signature Analysis On Diagnosis
Abstract:Background: To examine the hypothesis that ACE2 and TMPRSS2 expression are related to disease susceptibility and severity across age groups and to evaluate the role children play in the household transmission of SARS-CoV-2.Methods: We used a combined serological strategy to confirm past infection in subjects diagnosed with COVID-19 between march 10th and June 2nd 2020 and to evaluate their household members. We also quantified ACE2 and TPMRSS2 expression from saliva. A total of 258 households were included in … Show more
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