Effect of Withania somnifera (L.) Dunal aqueous root extract on reinstatement using conditioned place preference and brain GABA and dopamine levels in alcohol dependent animals

Marathe, Padmaja A; Satam, S.D.; Raut, Sanket B; Shetty, Yashashri C; Pooja, Sharma; Raut, Atul; Kale, Pravin Popatrao; Rege, Nirmala N

doi:10.1016/j.jep.2020.113304

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…A dose-dependent increase in the effect was observed in this study. 31 Similar effect was also observed by Escher et al, who reported reduced selfadministration of alcohol by memantine in schedule induced polydipsia model in C57BL6 mice at a dose of 10 and 25 mg/kg. 22 However, both these studies have not reported significant alteration in the water intake as was observed in our study.…”

Section: Discussionsupporting

confidence: 79%

Celastrus paniculatus and memantine prevent alcohol dependence and improve decision making in alcohol dependent C57BL6 mice

Pooja

Raut²,

Kamat³

et al. 2023

Int J Basic Clin Pharmacol

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Background: Alcohol use disorder poses a huge burden with only a handful of approved drugs. AUD is associated with impaired decision-making that leads to compulsive drinking despite negative consequences. A drug that decreases alcohol consumption as well as improves decision-making may thus prove more useful. This study was planned to evaluate the effect of two drugs, Celastrus paniculatus and memantine on alcohol preference and decision impairment in alcohol-dependent mice. Methods: In part 1, the effect of both the study drugs on alcohol consumption was studied using intermittent access model in 70 male C57BL6 mice. In part 2, effect of drugs on decision making was studied using the rodent version of Iowa gambling task. Mice were divided in seven study groups: Group 1-3: Celastrus paniculatus (140, 280, and 560 mg/kg), Group 4: memantine (25 mg/kg), Group 5: vehicle control 1 (Milk), Group 6: vehicle control 2 (normal saline) and Group 7: naltrexone(1mg/kg). Results: Percentage alcohol preference was lower in test groups i.e., Celastrus paniculatus at medium (40.90±15.18%) and high doses (31.79±7.46%) vs. milk (82.74±8.53%; p<0.05); and in memantine group (36.28±10.99%) vs. normal saline (83.27±5.51%; p<0.05). The results were not significantly different to Naltrexone (19.70±6.90%). Percentage preference to disadvantageous arms was also lower in Celastrus paniculatus, at medium (50.52±1.92%) and high doses (48.11±2.43%) compared to milk (54.47±2.73%; p<0.05) and memantine (47.45±1.67%) compared to normal saline (54.00±2.73%; p<0.05), indicating better decision-making ability in the test groups. The findings were comparable to Naltrexone group (45.43±2.52%). Conclusions: These results indicate that Celastrus paniculatus and memantine reduce alcohol consumption and improve decision making in alcohol-dependent mice.

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Section: Discussionsupporting

confidence: 79%

Celastrus paniculatus and memantine prevent alcohol dependence and improve decision making in alcohol dependent C57BL6 mice

Pooja

Raut²,

Kamat³

et al. 2023

Int J Basic Clin Pharmacol

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“…When A11-DA neurons become dysfunctional in PD, the unopposed inhibition by the latter causes sensory dysesthesia, which is typical of RLS in PD [ 8 ]. Experimental evidence has shown that administration of Withania somnifera increases dopamine levels in the midbrain and corpus striatum [ 3 , 9 ]. This could counter the GABA/glycine-dopamine imbalance as explained above.…”

Section: Discussionmentioning

confidence: 99%

Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson’s Disease: A Case Report

Chaudhari¹,

Tiwari²,

Chaudhari³

et al. 2021

Cureus

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Non-motor symptoms of Parkinson's disease (PD), such as insomnia and restless legs syndrome (RLS), tend to worsen and become refractory as neurodegeneration progresses. We report the case of a 72-year-old female with a six-year history of PD and two-and-half-year history of insomnia and refractory RLS. We added a neuroprotective agent, Withania somnifera, to the existing treatment regimen for her insomnia. Besides the partial remission of her insomnia and motor symptoms of PD, there was a complete reversal of the RLS symptoms. Withania somnifera has been shown to improve PD symptoms by preventing oxidative damage of the nigrostriatal dopaminergic neurons and improving dopamine levels in the midbrain and corpus striatum. Our case provides the first-time evidence where Withania somnifera added for insomnia caused a complete remission of refractory RLS, possibly due to its anti-apoptotic and pro-dopaminergic actions. Withania somnifera could prove beneficial in cases where the disease advances but further addition of dopamine agonists for refractory RLS is not possible due to the risk of dopamine augmentation.

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Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool

Yunusoğlu

2022

Alcohol

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Effect of Withania somnifera (L.) Dunal aqueous root extract on reinstatement using conditioned place preference and brain GABA and dopamine levels in alcohol dependent animals

Cited by 6 publications

References 37 publications

Celastrus paniculatus and memantine prevent alcohol dependence and improve decision making in alcohol dependent C57BL6 mice

Celastrus paniculatus and memantine prevent alcohol dependence and improve decision making in alcohol dependent C57BL6 mice

Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson’s Disease: A Case Report

Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool

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