Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries

Pereira, Virginia M.; Reis, Fernando M.; Casalechi, Maíra; Reis, Adelina Martha dos

doi:10.2174/0929866527666200826104410

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…The ACE2 transcript expression was downregulated in both CGCs and MGCs from women with PCOS. This observation corroborated with our microarray gene expression analysis, reported plasma levels of ACE2 in PCOS women and expression level in oocytes of rat model of PCOS [ 30 , 37 , 38 ]. BSG is known to be regulated by estrogen and progesterone and is important for fertilization and implantation [ 25 ].…”

Section: Discussionsupporting

confidence: 90%

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Naigaonkar

Patil

Joseph

et al. 2022

Arch Gynecol Obstet

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Section: Discussionsupporting

confidence: 90%

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Naigaonkar

Patil

Joseph

et al. 2022

Arch Gynecol Obstet

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“…The ACE2 expression was downregulated in both CGCs and MGCs from women with PCOS in our study. This observation of lower ACE2 corroborates with our microarray gene expression analysis of granulosa cells, plasma levels reported in PCOS women and studies on oocytes from rat model of PCOS [35,42,43]. Localization and expression of BSG receptor has been a point of interest considering that BSG is known to be regulated by estrogen and progesterone and is important for fertilization and implantation [30].…”

Section: Discussionsupporting

confidence: 88%

Ovarian Granulosa Cells From Women With Pcos Express Low Levels of Sars-Cov-2 Receptors and Co-Factors

Naigaonkar

Patil

Joseph

et al. 2021

Preprint

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Purpose: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is global pandemic with more than 3 million deaths so far. Female reproductive tract organs express coronavirus-associated receptors and factors (SCARFs); suggesting they may be susceptible to SARS-CoV-2 infection however the susceptibility of ovary/follicle/oocyte to the same is still elusive. Co-morbidities like obesity, type-2 diabetes mellitus, cardiovascular disease etc. increase the risk of SARS-CoV-2 infection. These features are common in women with polycystic ovary syndrome (PCOS), warranting further scope to study SCARFs expression in ovary of these women. Materials and methods: SCARFs expression in ovary and ovarian tissues of women with PCOS and healthy women was explored by analyzing publically available microarray datasets. Transcript expression of SCARFs were investigated in mural and cumulus granulosa cells (MGCs and CGCs) from control and PCOS women undergoing in vitro fertilization (IVF). Results: Microarray data revealed that ovary expresses all genes necessary for SARS-CoV-2 infection. PCOS women mostly showed down-regulated/unchanged levels of SCARFs. MGCs and CGCs from PCOS women showed lower expression of receptors ACE2, BSG and DPP4 and protease CTSB than in controls. MGCs showed lower expression of protease CTSL in PCOS than in controls. Expression of TMPRSS2 was not detected in both cell types. Conclusions: Human ovarian follicle may be susceptible to SARS-CoV-2 infection. Lower expression of SCARFs in PCOS indicate that the risk of SARS-CoV-2 infection to the ovary may be lesser in these women than controls. This knowledge may help in safe practices at IVF settings in the current pandemic. Keywords: SARS-CoV-2, COVID-19, Ovarian granulosa cells, Oocyte, PCOS, IVF

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“…In diabetic rodent models, AVE significantly enhanced erectile and endothelial function [ 79 ]. Furthermore, another study reported the protective effect of AVE on ovarian function in a rat model of polycystic ovary syndrome, showing reductions in ovarian oxidative stress, improvements in follicular development, and restoration of estrous cyclicity [ 80 ]. These findings suggest a potential therapeutic application of AVE in ameliorating reproductive dysfunction which is consistent with our results.…”

Section: Discussionmentioning

confidence: 99%

Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages

Navaneethabalakrishnan,

Goodlett,

Smith

et al. 2024

Clinical Science

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Salt-sensitive hypertension (SSHTN) is associated with M1 macrophage polarization and inflammatory responses, leading to inflammation-associated lymphangiogenesis and functional impairment across multiple organs, including kidneys and gonads. However, it remains unclear whether promoting M2 macrophage polarization can alleviate the hypertension, inflammation, and end organ damage in mice with salt sensitive hypertension (SSHTN). Male and female mice were made hypertensive by administering nitro-L-arginine methyl ester hydrochloride (L-NAME; 0.5 mg/mL) for 2 weeks in the drinking water, followed by a 2-week interval without any treatments, and a subsequent high salt diet for 3 weeks (SSHTN). AVE0991 (AVE) was intraperitoneally administered concurrently with the high salt diet. Control mice were provided standard diet and tap water. AVE treatment significantly attenuated BP and inflammation in mice with SSHTN. Notably, AVE promoted M2 macrophage polarization, decreased pro-inflammatory immune cell populations, and improved function in renal and gonadal tissues of mice with SSHTN. Additionally, AVE decreased lymphangiogenesis in the kidneys and testes of male SSHTN mice and the ovaries of female SSHTN mice. These findings highlight the effectiveness of AVE in mitigating SSHTN-induced elevated BP, inflammation, and end organ damage by promoting M2 macrophage polarization and suppressing pro-inflammatory immune responses. Targeting macrophage polarization emerges as a promising therapeutic approach for alleviating inflammation and organ damage in SSHTN. Further studies are warranted to elucidate the precise mechanisms underlying AVE-mediated effects and to assess its clinical potential in managing SSHTN.

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Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries

Cited by 8 publications

References 38 publications

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factors

Ovarian Granulosa Cells From Women With Pcos Express Low Levels of Sars-Cov-2 Receptors and Co-Factors

Differential changes in end organ immune cells and inflammation in salt-sensitive hypertension: effects of increasing M2 macrophages

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