Repair function of essential oil from Crocodylus Siamensis (Schneider, 1801) on the burn wound healing via up-regulated growth factor expression and anti-inflammatory effect

Li, Hualiang; Liu, Xiaotian; Huang, Shaomin; Xiong, You-Xiong; Zhang, Ziran; Zheng, Yan; Chen, Qing‐Xi; Chen, Qionghua

doi:10.1016/j.jep.2020.113286

Cited by 10 publications

(1 citation statement)

References 39 publications

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“…There are few studies on the effects of COS on fibroblast signaling pathways. In MAPK signaling pathway, p38 is one of the key factors in the regulation of cell proliferation and differentiation ( Li et al, 2021 ). We chose the p38 pathway to further verify that COS could promote wound healing through MAPK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Chitosan degradation products promote healing of burn wounds of rat skin

Zhang

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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Burns can impair the barrier function of the skin, and small burns can also cause high mortality. The WHO has described that over 180,000 people die of burns worldwide each year. Thus, the treatment of burn wounds is a major clinical challenge. Chitooligosaccharides (COS) are alkaline amino oligosaccharides with small molecular weights obtained by enzyme or chemical degradation of chitosan. With the characteristics of biocompatibility, water solubility and degradability, it has attracted increasing attention in the fields of biomedicine. In the present study, we used COS to treat deep second-degree burn wounds of rat skin and found that COS was able to promote wound healing. We also revealed that COS could promote fibroblast proliferation. Transcriptome sequencing analysis was performed on COS-treated fibroblasts to identify the underlying mechanisms. The results showed that COS was able to promote wound healing through regulation of the mitogen-activated protein kinase (MAPK) pathway and growth factor Hepatocyte Growth Factor (HGF). Our results provide a potential drug for burn wound therapy and the related molecular mechanism.

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Section: Discussionmentioning

confidence: 99%

Chitosan degradation products promote healing of burn wounds of rat skin

Zhang

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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Preparation, Characterization, and Biological Evaluation of Transparent Thin Carboxymethyl‐Chitosan/Oxidized Carboxymethyl Cellulose Films as New Wound Dressings

Jiang

Wang

et al. 2021

Macromolecular Bioscience

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Full thickness burns in which the damage penetrates deep into the skin layers and reaches underneath the muscle, compel the need for more effective cure. Herein, cross-linked carboxymethyl-chitosan (CM-chitosan) films, prepared by Schiff base association with oxidized carboxymethyl cellulose (OCMC), are investigated regarding the wound healing capacity on full thickness burn injuries in vivo. Transparent thin CM-chitosan/OCMC films are obtained with tensile strength reaching 6.11 MPa, elongation at break above 27%, and water absorption more than 800%, which operates in favor of absorbing excess exudate and monitoring the wound status. Furthermore, the nonadherent CM-chitosan/OCMC films, with satisfactory biodegradability, cell, and tissue compatibility, are readily used to the wound sites and easily removed following therapy on scalded tissue so as to alleviate the suffering from burn. The films efficiently promote epithelial and dermal regeneration compared to the control, achieving 75.9% and 94.4% wound closure, respectively, after 14 and 27 days. More importantly, CM-chitosan/OCMC films accelerate wound healing with natural mechanisms which include controlling inflammatory response, reducing apoptosis, promoting fibroblast cell proliferation, and collagen formation. In conclusion, the CM-chitosan/OCMC films elevate the repair ratio of burn injuries and have great potential for facilitating the healing process on full-thickness exuding wounds.

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