Vitamin D Receptor Gene Polymorphisms and the Risk of Metabolic Syndrome (MetS): A Meta-Analysis

Totonchi, Hamidreza; Rezaei, Ramazan; Noori, Shokoofe; Azarpira, Negar; Mokarram, Pooneh; Imani, Danyal

doi:10.2174/1871530320666200805101302

Cited by 6 publications

(3 citation statements)

References 61 publications

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“…Vitamin D deficiency can "turn on" the activation of the renin gene, which leads to an increase in angiotensin II levels, and this, in turn, can lead to hypertension and hypertrophy of the ventricles of the heart. In addition, an increase in the level of angiotensin II may lead to an increase in the production of reactive oxygen species (ROS) and activation of G-proteins, such as Rho A, which threatens the inhibition of pathways necessary for intracellular glucose transport, and, consequently, prerequisites for the development of insulin resistance and the start of the mechanisms of pathogenesis of metabolic syndrome [46][47][48][49][50].…”

Section: Clinical and Genetic Aspects Of Mht And Thrombotic Complicat...mentioning

confidence: 99%

Clinical and genetic aspects of menopausal hormone therapy - a modern paradigm. What changed COVID-19 pandemic?

Zhuravleva

Хамошина

Оразов

et al. 2022

Vestn. Ross. univ. družby nar., Ser. Med.

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In the modern paradigm of public health protection, much attention is paid to the health of women in peri- and postmenopause, and a personalized approach prevails. It is generally recognized that the pathogenetic therapy of menopausal disorders is hormone therapy. But the COVID-19 pandemic has made its own adjustments to the routine strategy of choosing menopausal hormone therapy (MHT). The purpose of this review was to analyze studies on the dependence of the effectiveness of MHT on clinical and genetic aspects in the context of the ongoing COVID-19 pandemic. The review highlights the main risks of MHT for thromboembolic diseases and coagulation complications characteristic of COVID-19, discusses genetic predispositions that aggravate the course of the post-COVID period, as well as the effectiveness of estrogens in protecting the vascular endothelium and increasing the number of CD4+ T cells, providing an adequate immune response when infected with SARS-CoV-2. Numerous studies show that the complications characteristic of the severe course of COVID-19 are multifactorial in nature and cannot be unambiguously explained only by genetic predisposition. However, with the development of personalized medicine, special attention should be paid to the study of genetic aspects that can equally contribute to the occurrence of menopausal disorders in healthy women and aggravate the course of the post-pregnancy period. The data presented allow us to conclude that in the context of the ongoing COVID-19 pandemic at the population level, MHT can bring significant benefits to women during menopause due to the beneficial effect of estrogens on vascular walls. Additional study of the relationship between the course of the postcovid period in MHT users and polymorphisms of candidate genes that determine the risks of thrombotic complications and metabolic consequences is required.

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Section: Clinical and Genetic Aspects Of Mht And Thrombotic Complicat...mentioning

confidence: 99%

Clinical and genetic aspects of menopausal hormone therapy - a modern paradigm. What changed COVID-19 pandemic?

Zhuravleva

Хамошина

Оразов

et al. 2022

Vestn. Ross. univ. družby nar., Ser. Med.

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“…Найбільш поширеними й вивченими поліморфізмами гена рецептора вітD є rs7975232 (ApaI), rs1544410 (BsmI), rs2228570 (FokI) та rs731236 (TaqI). Окремі дослідження продемонстрували зв'язок цих поліморфізмів із підвищеним ризиком ЦД-2 і метаболічними порушеннями, зокрема в дітей, підлітків та жінок із СПКЯ [60][61][62].…”

Section: роль вітаміну D та поліморфізму його рецептора в розвитку ір при Mcunclassified

Insulin resistance in the ХХІ century: multimodal approach to assessing causes and effective correction

Bobryk

Тутченко²,

Сидорова³

et al. 2021

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In a broad sense, insulin resistance (IR) is the impairment of the biological response of target tissues to insulin stimulation. IR plays a leading role in the development of metabolic syndrome, the global prevalence of which continues to grow, despite the significant efforts of medical systems. The multicomponent nature of metabolic syndrome implies its complex and heterogeneous pathogenesis, knowledge about which is annually updated with new details as a result of scientific research.This review systematizes the results of recent studies on risk factors and pathogenetic links in the development of IR, prospects and existing experience of using these data in clinical practice with an emphasis on assessing the level of melatonin and vitamin D. The issue of timely and reliable laboratory confirmation of IR is relevant not only for endocrinologists, but also for specialists in almost all areas. In clinical use apart from indirect methods of IR-assessment like HOMA-IR, there is an informative test intact proinsulin.Recently, the increasing attention of researchers is attracted by such factors of the development of IR as vitamin D deficiency and disturbances in chrono- and biorhythms. Today, their role in the pathogenesis of IR can be considered proven, which makes it possible to consider vitamin D and melatonin as therapeutic agents in an integrated approach to the prevention and correction of IR. Statistical analysis of the research results of the “DILA” Medical Laboratory and clinical data provided by the Department of Endocrinology of the O.O. Bogomolets National Medical University also showed an association of vitamin D and melatonin levels with IR.Thus, a review of scientific sources over the last 5 years clearly demonstrates the growing urgency of the problem of IR and metabolic syndrome, the need to reconsider their management from assessing traditional etiopathogenetic factors (alimentary) to taking into account the maximum spectrum of genetic aspects and exogenous impacts. An important place among the latter belongs to an objective assessment of the vitamin D and melatonin levels for adequate pharmacological correction.

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“…In this context, it is known that the biological functions of vitamin D are mediated by several genes involved in its metabolism and synthesis [ 14 ]. Furthermore, there is a possible association of the polymorphisms of genes that encode the enzymes responsible for vitamin D synthesis with different outcomes, such as the risk of obesity and MS [ 15 ]. Among the main genes involved in the bioactivation of vitamin D, CYP2R1 is responsible for the hydroxylation of vitamin D3 to 25-hydroxyvitamin D3 (25(OH)D).…”

Section: Introductionmentioning

confidence: 99%

Association of CYP2R1 and VDR Polymorphisms with Metabolic Syndrome Components in Non-Diabetic Brazilian Adolescents

et al. 2022

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Associations between vitamin D deficiency and metabolic syndrome (MS) have been reported; however, the underlying biological mechanisms remain controversial. The aim of this study was to investigate the associations of CYP2R1 and VDR variants with MS and MS components in non-diabetic Brazilian adolescents. This cross-sectional study included 174 adolescents who were classified as overweight/obese. Three CYP2R1 variants and four VDR variants were identified by allelic discrimination. The CYP2R1 polymorphisms, rs12794714 (GG genotype) (odds ratio [OR] = 3.54, 95% confidence interval [CI] = 1.24–10.14, p = 0.023) and rs10741657 (recessive model—GG genotype) (OR = 3.90, 95%CI = 1.18–12.92, p = 0.026) were significantly associated with an increased risk of MS and hyperglycemia, respectively. The AG + GG genotype (dominant model) of the rs2060793 CYP2R1 polymorphism was associated with hyperglycemia protection (OR = 0.28, 95%CI = 0.08–0.92, p = 0.037). Furthermore, the CC genotype (recessive model) of the rs7975232 VDR polymorphism was significantly associated with a risk of hypertension (OR = 5.91, 95%CI = 1.91–18.32, p = 0.002). In conclusion, the CYP2R1 rs12794714 polymorphism could be considered a possible new molecular marker for predicting the risk of MS; CYP2R1 rs10741657 polymorphism and VDR rs7975232 polymorphism are associated with an increased risk of diabetes and hypertension in adolescents with overweight/obesity.

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Vitamin D Receptor Gene Polymorphisms and the Risk of Metabolic Syndrome (MetS): A Meta-Analysis

Cited by 6 publications

References 61 publications

Clinical and genetic aspects of menopausal hormone therapy - a modern paradigm. What changed COVID-19 pandemic?

Clinical and genetic aspects of menopausal hormone therapy - a modern paradigm. What changed COVID-19 pandemic?

Insulin resistance in the ХХІ century: multimodal approach to assessing causes and effective correction

Association of CYP2R1 and VDR Polymorphisms with Metabolic Syndrome Components in Non-Diabetic Brazilian Adolescents

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