Peripheral serotonin regulates glucose and insulin metabolism in Holstein dairy calves

Field, Sena L.; Marrero, Marcela G.; Dado-Senn, Bethany; Skibiel, Amy L.; Ramos, Patricia Maloso; Scheffler, T.; Laporta, Jimena

doi:10.1016/j.domaniend.2020.106519

Cited by 7 publications

(4 citation statements)

References 45 publications

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“…While reports on glucose intolerance and insulin resistance were quite consistent, findings on body weight and adiposity as well as on blood levels of glucose, insulin, and/or triglycerides in 5HTT knock-out (5HTTKO) animals were rather inconsistent across studies [22,[24][25][26][27]. Furthermore, manipulation of 5HT activity by administration of its metabolic precursor or the amine itself showed contradictory effects on circulating glucose/insulin levels [28,29]. In humans, pharmacological inhibition of 5HTT with selective serotonin reuptake inhibitors (SSRIs), which act on both the central and peripheral 5HT systems, has been associated with weight loss, no changes in body weight or mild to moderate weight gain [30,31].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis

Kesić

Baković

Stojković

et al. 2021

IJMS

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Central and peripheral serotonin (5HT) have opposing functions in the regulation of energy homeostasis. Both increasing 5HT signaling in the brain and decreasing 5HT signaling in the periphery have been proposed as potential treatments for obesity. This study investigates the relationship between constitutionally high or low 5HT activity and systemic net energy balance. Two sublines of rats with high and low whole-body 5HT tone, obtained by selective breeding for platelet 5HT parameters, were examined for fat accumulation in different white adipose tissue (WAT) depots, glucose/insulin tolerance, blood metabolic parameters, and expression of various metabolic genes. High-5HT animals, unlike their low-5HT counterparts, developed widespread intra-abdominal obesity associated with glucose and insulin intolerance, which worsened with age. They also had elevated blood glucose and lipid parameters but showed no significant changes in circulating leptin, resistin, and adipsin levels. Surprisingly, adiponectin levels were increased in plasma but reduced in the WAT of high-5HT rats. A limited number of metabolic genes belonging to different functional classes showed differential expression in WAT of high-5HT compared to low-5HT rats. Overall, a constitutive increase in 5HT tone is associated with a positive energy balance acting through subtle dysregulation of a broad spectrum of metabolic pathways.

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Section: Introductionmentioning

confidence: 99%

Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis

Kesić

Baković

Stojković

et al. 2021

IJMS

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“…Reduce of serotonin level at un-control DM type 2 group demonstrate that serotonin hormone have role in regulation of serum glucose level via insulin hormone regulation (6) . Serotonin is neurotransmitter commonly found in brain cell but it also present in beta cells of pancreas ,it made bond with enzymes .…”

Section: Discussionmentioning

confidence: 89%

Role of Serotonin Hormone at Development of Diabetes Mellitus Type 2 disease

Khalaf¹,

Al-Tameemi²,

Kargule³

2021

JUSST

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Subject :Diabetes Mellitus (DM) type 2 is most common disease characterized by elevation of serum glucose level due to impair insulin production or impair cell response to insulin .Serotonin is hormonal neurotransmitter commonly found in brain cell but it also present in beta cells of pancreas . It is key hormone that stabilizes mood, feelings of well-being, and happiness . Objective of the Study: Role of serotonin in development of DM type 2 disease . Materials and Methods: This study was done on 30 patients with un-control DM type2 patients and 30 control DM type 2 patients , the all subjects age within this study were more than 50 years of both genders .After obtained serum , immediately used quantity method for measured level of serum serotonin concentration . Results: This study shows reduce of serum serotonin concentration level in un-control DM type 2 group compare with control group . Conclusion: This study confirms that decreased serum serotonin concentration level can act as support development of DM type 2 disease .

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“…RNA quantity and quality were measured using the Implen Nanophotometer and one μg of RNA was reverse transcribed using iScript Reverse Transcription Supermix (Bio-Rad, Hercules, CA; #1708841). Real time- qPCR was performed using CFX96 Real-Time PCR detection System (Bio-Rad) with reaction mixtures and cycling conditions performed as previously described [ 24 ]. The geometric mean of three housekeeping genes, S15, Rsp9, and K8 for mammary and Rsp9 and S15 for liver tissue, were calculated to normalize gene expression.…”

Section: Methodsmentioning

confidence: 99%

Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation

Field,

Galvan,

Hernandez

et al. 2024

PLoS ONE

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During lactation, the murine mammary gland is responsible for a significant increase in circulating serotonin. However, the role of mammary-derived serotonin in energy homeostasis during lactation is unclear. To investigate this, we utilized C57/BL6J mice with a lactation and mammary-specific deletion of the gene coding for the rate-limiting enzyme in serotonin synthesis (TPH1, Wap-Cre x TPH1FL/FL) to understand the metabolic contributions of mammary-derived serotonin during lactation. Circulating serotonin was reduced by approximately 50% throughout lactation in Wap-Cre x TPH1FL/FL mice compared to wild-type mice (TPH1FL/FL), with mammary gland and liver serotonin content reduced on L21. The Wap-Cre x TPH1FL/FL mice had less serotonin and insulin immunostaining in the pancreatic islets on L21, resulting in reduced circulating insulin but no changes in glucose. The mammary glands of Wap-Cre x TPH1FL/FL mice had larger mammary alveolar areas, with fewer and smaller intra-lobular adipocytes, and increased expression of milk protein genes (e.g., WAP, CSN2, LALBA) compared to TPH1FL/FL mice. No changes in feed intake, body composition, or estimated milk yield were observed between groups. Taken together, mammary-derived serotonin appears to contribute to the pancreas-mammary cross-talk during lactation with potential implications in the regulation of insulin homeostasis.

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Peripheral serotonin regulates glucose and insulin metabolism in Holstein dairy calves

Cited by 7 publications

References 45 publications

Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis

Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis

Role of Serotonin Hormone at Development of Diabetes Mellitus Type 2 disease

Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation

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