Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation
Sena L. Field,
Everardo Anta Galvan,
Laura L. Hernandez
et al.
Abstract:During lactation, the murine mammary gland is responsible for a significant increase in circulating serotonin. However, the role of mammary-derived serotonin in energy homeostasis during lactation is unclear. To investigate this, we utilized C57/BL6J mice with a lactation and mammary-specific deletion of the gene coding for the rate-limiting enzyme in serotonin synthesis (TPH1, Wap-Cre x TPH1FL/FL) to understand the metabolic contributions of mammary-derived serotonin during lactation. Circulating serotonin wa… Show more
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