Resistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis

Vasilceac, Fernando Augusto; Marqueti, Rita de Cássia; Neto, Ivo Vieira de Sousa; Nascimento, Dahan da Cunha; Souza, Mariana Carvalho de; Durigan, João Luíz Quagliotti; Mattiello, Stela Márcia

doi:10.1016/j.bjpt.2020.03.002

Cited by 6 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, aerobic exercise can reduce the expression in IL-1β, caspase-3, and MMP-13, and prevent the degeneration of cartilage caused by KOA in model rats ( Assis et al, 2016 ). Resistance training can decrease MMP-2 activity in quadriceps tendon in a rat model of osteoarthritis ( Vasilceac et al, 2021 ). Treadmills and wheel exercise can decrease the levels of IL-1β, IL-6, and TNF-α, and regulate JNK/NF-ΚB signaling to prevent inflammation in model rats with KOA ( Chen et al, 2020 ).…”

Section: Exercise Training and Koamentioning

confidence: 99%

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

et al. 2021

View full text Add to dashboard Cite

Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone degeneration, as well as synovitis, are the main pathological changes associated with knee osteoarthritis. Mechanical overload, inflammation, metabolic factors, hormonal changes, and aging play a vital role in aggravating the progression of knee osteoarthritis. The main treatments for knee osteoarthritis include pharmacotherapy, physiotherapy, and surgery. However, pharmacotherapy has many side effects, and surgery is only suitable for patients with end-stage knee osteoarthritis. Exercise training, as a complementary and adjunctive physiotherapy, can prevent cartilage degeneration, inhibit inflammation, and prevent loss of the subchondral bone and metaphyseal bone trabeculae. Increasing evidence indicates that exercise training can improve pain, stiffness, joint dysfunction, and muscle weakness in patients with knee osteoarthritis. There are several exercise trainings options for the treatment of knee osteoarthritis, including aerobic exercise, strength training, neuromuscular exercise, balance training, proprioception training, aquatic exercise, and traditional exercise. For Knee osteoarthritis (KOA) experimental animals, those exercise trainings can reduce inflammation, delay cartilage and bone degeneration, change tendon, and muscle structure. In this review, we summarize the main symptoms of knee osteoarthritis, the mechanisms of exercise training, and the therapeutic effects of different exercise training methods on patients with knee osteoarthritis. We hope this review will allow patients in different situations to receive appropriate exercise therapy for knee osteoarthritis, and provide a reference for further research and clinical application of exercise training for knee osteoarthritis.

show abstract

Section: Exercise Training and Koamentioning

confidence: 99%

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Additionally, resistance training (RT) has been linked with therapeutic effects via regulating the expression of MMPs. Vasilceac et al showed that RT induced MMP-2 downregulation in the quadriceps tendon of rats [ 67 ]. Membrane-bound MMP-17 (exclusively expressed by muscle cells) is required to repair inflammation-induced damaged smooth muscle cells [ 68 ].…”

Section: Function Of Mmps In Musculoskeletal Diseasesmentioning

confidence: 99%

“…Membrane-bound MMP-17 (exclusively expressed by muscle cells) is required to repair inflammation-induced damaged smooth muscle cells [ 68 ]. Many diseases, such as OA, involve dysregulation in ECM degradation [ 67 ]. Hence, exploring the role of therapies such as RT in MMPs expression and ECM degradation may provide insights for managing OA.…”

Section: Function Of Mmps In Musculoskeletal Diseasesmentioning

confidence: 99%

Role of Matrix Metalloproteinases in Musculoskeletal Diseases

et al. 2022

View full text Add to dashboard Cite

Musculoskeletal disorders include rheumatoid arthritis, osteoarthritis, sarcopenia, injury, stiffness, and bone loss. The prevalence of these conditions is frequent among elderly populations with significant mobility and mortality rates. This may lead to extreme discomfort and detrimental effect on the patient’s health and socioeconomic situation. Muscles, ligaments, tendons, and soft tissue are vital for body function and movement. Matrix metalloproteinases (MMPs) are regulatory proteases involved in synthesizing, degrading, and remodeling extracellular matrix (ECM) components. By modulating ECM reconstruction, cellular migration, and differentiation, MMPs preserve myofiber integrity and homeostasis. In this review, the role of MMPs in skeletal muscle function, muscle injury and repair, skeletal muscle inflammation, and muscular dystrophy and future approaches for MMP-based therapies in musculoskeletal disorders are discussed at the cellular and molecule level.

show abstract

“…Low-intensity aerobic exercise had a better therapeutic effect in patients with severe OA ( Messier et al, 2021 ), while high-intensity aerobic exercise had a better therapeutic effect in patients with mild OA ( Multanen et al, 2017 ). In addition, strength training could reduce the activity of MMP-2 in the quadriceps tendon of the OA rat model ( Vasilceac et al, 2021 ), which was the most effective in improving muscle strength, and neuromuscular training was the best training method to relieve OA pain ( Ageberg and Roos, 2015 ). Swimming intervention in the early stage of OA can alleviate the stiffness of the knee joint and is better than land exercise ( Lund et al, 2008 ; Hsieh and Yang, 2018 ; Munukka et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, considering that collagen type II is an essential component of ECM, exercise may delay the progression of OA by inhibiting the degradation of ECM and promoting cartilage synthesis ( Assis et al, 2018 ). Vasilceac et al (2021) conducted resistance training for eight weeks for OA rats. They analyzed whether ELISA changed the activity of MMP-2 in the tendons around the knee joint and finally found that exercise could reduce the activity of MMP-2 in the quadriceps tendon of OA rats and greatly relieve the adverse effects of OA on the knee joint.…”

Section: Mechanism Of Exercise Improving Osteoarthritismentioning

confidence: 99%

Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism

Kong

Wang

Zhang

2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Osteoarthritis (OA) has a very high incidence worldwide and has become a very common joint disease in the elderly. Currently, the treatment methods for OA include surgery, drug therapy, and exercise therapy. In recent years, the treatment of certain diseases by exercise has received increasing research and attention. Proper exercise can improve the physiological function of various organs of the body. At present, the treatment of OA is usually symptomatic. Limited methods are available for the treatment of OA according to its pathogenesis, and effective intervention has not been developed to slow down the progress of OA from the molecular level. Only by clarifying the mechanism of exercise treatment of OA and the influence of different exercise intensities on OA patients can we choose the appropriate exercise prescription to prevent and treat OA. This review mainly expounds the mechanism that exercise alleviates the pathological changes of OA by affecting the degradation of the ECM, apoptosis, inflammatory response, autophagy, and changes of ncRNA, and summarizes the effects of different exercise types on OA patients. Finally, it is found that different exercise types, exercise intensity, exercise time and exercise frequency have different effects on OA patients. At the same time, suitable exercise prescriptions are recommended for OA patients.

show abstract

Resistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis

Cited by 6 publications

References 32 publications

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis

Role of Matrix Metalloproteinases in Musculoskeletal Diseases

Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism

Contact Info

Product

Resources

About