Bacteriological Profile and Antibiotic Resistance in Patients with Urinary Tract Infection in Tertiary Care Teaching Hospital in Western Rajasthan India

Abstract

Background: UTI is one of the commonest bacterial infection with significant economic burden on the health care system in developing countries like India. Rising antibiotic resistance is a matter of great concern. Aims: The aim of this study was to determine the bacteriological profile and antibiotic resistance pattern in patients with UTI in Tertiary Care Hospital in western Rajasthan India. Settings and Design: A cross-sectional, descriptive study was conducted from December 2017 to November 2018 at MDM hospital S.N. medical college, Jodhpur in western Rajasthan. Materials and methods: All the patients with symptoms of urinary tract infection, presented in the outpatient unit or developed symptoms within 48 hr of hospitalisation were included in the study. Only those patients with significant bacteriuria (105 cfu/ml) were included. Results: The total prevalence of UTI was 55.34% in our study. Most common bacteria isolated in urine sample was E. coli (37.2%) followed by Klebsiella pneumonia (10.2%), Enterococci spp. (3.3%), and Pseudomonas spp. (1.9%). Gram-negative bacteria represented 92.44% of the isolates. E. coli showed maximum resistance towards co-trimoxazole (78.75%) followed by cefuroxime (77.5%) & ciprofloxacin (72.5%). Klebsiella pneumoniae showed the highest resistance against co-trimoxazole (23.75%) and ciprofloxacin (23.75%). Conclusions: The present study gives an idea about the common trend of antibiotic resistance of uropathogens in this region. The findings in our study will help in the formulation of antibiotic policy and determination of empirical treatment of UTI in this region.

Antimicrobial Resistance Among Uropathogens: Surveillance Report From South India

“…In our analysis, in both periods, the most common organisms were Escherichia coli (56.6% vs 51.6%), Klebsiella pneumoniae (14.7% vs 16.5%), Enterococcus faecalis (11.6% vs 12%), and Pseudomonas aeruginosa (4.5% vs 5%). This spectrum is similar to the previous studies by Meena et al [ 12 ], and Shah et al [ 6 ] from India; Sorlozano et al [ 13 ] from Spain; Eure et al [ 14 ] and Sharma et al [ 15 ] from Grenada; and Lagunas-Rangel [ 16 ] from Mexico. Most authors have reported Escherichia coli and Klebsiella pneumoniae among the top three causative organisms for UTI (Table 4 ), which is similar to our study.…”

Rising Resistance in Uropathogens With an Indication of Nitrofurantoin Mic Creep

“…The most common uropathogens found in the present study are Escherichia coli (n=736, 47.8%) followed by Klebsiella spp (n=178, 11%). This was similar to previous studies carried out by Meena et al 16 and Shah et al 15 from India; Solórzano et al 17 from Spain; Eure et al 18 and Sharma et al 19 from Grenada; and Lagunas-Rangel 20 from Mexico. Gram negative bacteria such as E. coli and Klebsiella spp.…”

Prevalence of ESBL Producing Bacteria in Community-Acquired UTI from Eastern Part of India

“…The same kind of findings was observed in a study by Meena M et al in which cases of E.coli, K.pneumoniae were higher at 37.2% and 10.2% respectively. 16 The antibiogram chart of isolates revealed high resistance against nalidixic acid and ciprofloxacin followed by cefixime at the same time susceptible to ertapenem, gentamicin followed by nitrofurantoin. Higher Nitrofurantoin and amoxyclav sensitivity corresponded to a study by Vijay P Singh and Abhishek Mehta where nitrofurantoin was suggested for empirical treatment.…”