Stage 1 acute kidney injury is independently associated with infection following cardiac surgery

Griffin, Benjamin R.; Teixeira, J. Pedro; Ambruso, Sophia; Bronsert, Michael; Pal, Jay D.; Cleveland, Joseph C.; Reece, T. Brett; Fullerton, David A.; Faubel, Sarah; Aftab, Muhammad

doi:10.1016/j.jtcvs.2019.11.004

Cited by 34 publications

(22 citation statements)

References 36 publications

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“…Based on the literature research, the following five of the nine significant variables were included into multivariate binary logistic regression (see Table 3 ): ECMO [ 9 , 10 , 11 ], all cause infection after surgery [ 12 , 13 ], levosimendan [ 14 , 15 , 16 ], duration of NE therapy [ 17 , 18 , 19 ] and increase in Tacrolimus plasma levels [ 18 , 20 , 21 ]. Evidence for the choice to include these five variables can be found as references next to each variable.…”

Section: Resultsmentioning

confidence: 99%

Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function

M‘Pembele

Roth

Stroda

et al. 2021

JCM

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Acute kidney injury (AKI), requiring renal replacement therapy (RRT). is a serious complication after orthotopic heart transplantation (HTX). In patients with preexisting impaired renal function, postoperative AKI is unsurprising. However, even in patients with preserved renal function, AKI requiring RRT is frequent. Therefore, this study aimed to identify risk factors associated with postoperative AKI requiring RRT after HTX in this sub-cohort. This retrospective cohort study included patients ≥18 years of age with preserved renal function (defined as preoperative glomerular filtration rate ≥60 mL/min) who underwent HTX between 2010 and 2021. In total, 107 patients were included in the analysis (mean age 52 ± 12 years, 78.5% male, 45.8% AKI requiring RRT). Based on univariate logistic regression, use of extracorporeal membrane oxygenation, postoperative infection, levosimendan therapy, duration of norepinephrine (NE) therapy and maximum daily increase in tacrolimus plasma levels were chosen to be included into multivariate analysis. Duration of NE therapy and maximum daily increase in tacrolimus plasma levels remained as independent significant risk factors (NE: OR 1.01, 95%CI: 1.00–1.02, p = 0.005; increase in tacrolimus plasma level: OR 1.18, 95%CI: 1.01–1.37, p = 0.036). In conclusion, this study identified long NE therapy and maximum daily increase in tacrolimus plasma levels as risk factors for AKI requiring RRT in HTX patients with preserved renal function.

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Section: Resultsmentioning

confidence: 99%

Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function

M‘Pembele

Roth

Stroda

et al. 2021

JCM

View full text Add to dashboard Cite

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“…Of the patients who developed AKI, only one was stage 2; the others were stage 1. Although relatively mild, stage 1 AKI is an independently risk factor for post-cardiac surgery infection, intensive care unit and hospital stays, and early and late mortality [ 20 , 21 ]. Therefore, since the choice of anesthetic agent is a modifiable risk factor for AKI, the results of this study are meaningful in that the choice of anesthetic technique could help improve the outcome of surgical patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of Anesthetic Technique on the Occurrence of Acute Kidney Injury after Spine Surgery: A Retrospective Cohort Study

Han

Koo

et al. 2021

JCM

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The effects of anesthetics on acute kidney injury (AKI) after spine surgery have not been evaluated fully. This study compared propofol-based total intravenous anesthesia (TIVA) and volatile anesthetics in the development of AKI after spine surgery. This retrospective study reviewed patients who underwent spine surgery between 2015 and 2019. A logistic regression analysis was performed to identify risk factors for AKI. Additionally, after propensity score matching, the incidence of AKI was compared between TIVA and volatile groups. Of the 4473 patients, 709 were excluded and 3764 were included in the logistic regression. After propensity score matching, 766 patients from each group were compared, and we found that the incidence of AKI was significantly lower in the TIVA group (1% vs. 4.2%, p < 0.001). In the multivariate logistic regression analysis, the risk factors for postoperative AKI were male sex (OR 1.85, 95% CI 1.18–3.06), hypertension (OR 2.48, 95% CI 1.56–3.94), anemia (OR 2.66, 95% CI 1.76–4.04), and volatile anesthetics (OR 4.69, 95% CI 2.24–9.84). Compared with volatile anesthetics, TIVA is associated with a reduced risk of AKI for patients who have undergone spine surgery.

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“…Based on the literature research, the following five of the nine significant variables were included into multivariate binary logistic regression (see Table 3): ECMO [9][10][11], all cause infection after surgery [12,13], levosimendan [14][15][16], duration of NE therapy [17][18][19] and increase in Tacrolimus plasma levels [18,20,21]. Evidence for the choice to include these five variables can be found as references next to each variable.…”

Section: Multivariate Analysismentioning

confidence: 99%

Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function

M‘Pembele

Roth

Stroda

et al. 2022

The Thoracic and Cardiovascular Surgeon

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Stage 1 acute kidney injury is independently associated with infection following cardiac surgery

Cited by 34 publications

References 36 publications

Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function

Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function

Effects of Anesthetic Technique on the Occurrence of Acute Kidney Injury after Spine Surgery: A Retrospective Cohort Study

Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function

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