31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis

Yıldız, Ayşegül; Sachs, Gary S.; Dorer, David J.; Renshaw, Perry F.

doi:10.1016/s0925-4927(01)00082-8

Cited by 77 publications

(72 citation statements)

References 37 publications

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“…Specifically, while several studies have observed increased PME signals in bipolar patients in the manic or depressed states compared to those in euthymia, a number of investigations have reported decreased PME levels in euthymic bipolar subjects compared to normal controls ( Table 9). Many of these findings were also evaluated in a metaanalysis of 31 P MRS research on bipolar disorder by Yildiz et al 113 , which confirmed reports of significantly lower PME levels in euthymic bipolar subjects vs normal controls. One 1998 study by Kato et al 48 did not find a difference in PME levels between euthymic bipolar subjects and controls, but had an extremely small sample group of only seven subjects.…”

Section: Impaired Phospholipid Metabolism In Bipolar Disordersupporting

confidence: 58%

Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research

2005

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Magnetic resonance spectroscopy (MRS) affords a noninvasive window on in vivo brain chemistry and, as such, provides a unique opportunity to gain insight into the biochemical pathology of bipolar disorder. Studies utilizing proton ( 1 H) MRS have identified changes in cerebral concentrations of N-acetyl aspartate, glutamate/glutamine, choline-containing compounds, myo-inositol, and lactate in bipolar subjects compared to normal controls, while studies using phosphorus ( 31 P) MRS have examined additional alterations in levels of phosphocreatine, phosphomonoesters, and intracellular pH. We hypothesize that the majority of MRS findings in bipolar subjects can be fit into a more cohesive bioenergetic and neurochemical model of bipolar illness that is both novel and yet in concordance with findings from complementary methodological approaches. In this review, we propose a hypothesis of mitochondrial dysfunction in bipolar disorder that involves impaired oxidative phosphorylation, a resultant shift toward glycolytic energy production, a decrease in total energy production and/or substrate availability, and altered phospholipid metabolism. Molecular Psychiatry (2005) 10, 900-919.

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Section: Impaired Phospholipid Metabolism In Bipolar Disordersupporting

confidence: 58%

Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research

2005

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“…The results of this meta-analysis support the hypothesis that bipolar patients exhibit alterations in membrane phospholipid metabolism, which may reflect both trait and state dependent abnormalities in signal transduction pathways. However, further studies assessing the effects of medications on PME and PDE concentrations in bipolar patients are necessary 51 to verify this notion.…”

Section: P (Phosphorus) Mrs Studiesmentioning

confidence: 99%

The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

2004

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The authors review existing structural and functional neuroimaging studies of patients with bipolar disorder and discuss how these investigations enhance our understanding of the neurophysiology of this illness. Findings from structural magnetic resonance imaging (MRI) studies suggest that some abnormalities, such as those in prefrontal cortical areas (SGPFC), striatum and amygdala exist early in the course of illness and, therefore, potentially, predate illness onset. In contrast, other abnormalities, such as those found in the cerebellar vermis, lateral ventricles and other prefrontal regions (eg, left inferior), appear to develop with repeated affective episodes, and may represent the effects of illness progression and associated factors. Magnetic resonance spectroscopy investigations have revealed abnormalities of membrane and second messenger metabolism, as well as bioenergetics, in striatum and prefrontal cortex. Functional imaging studies report activation differences between bipolar and healthy controls in these same anterior limibic regions. Together, these studies support a model of bipolar disorder that involves dysfunction within subcortical (striatalthalamic)-prefrontal networks and the associated limbic modulating regions (amygdala, midline cerebellum). These studies suggest that, in bipolar disorder, there may be diminished prefrontal modulation of subcortical and medial temporal structures within the anterior limbic network (eg, amygdala, anterior striatum and thalamus) that results in dysregulation of mood. Future prospective and longitudinal studies focusing on these specific relationships are necessary to clarify the functional neuroanatomy of bipolar disorder.

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“…Phosphodiesters showed no differences between patients and controls (103). Unipolar depression has been studied far less with 31 P MRS.…”

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confidence: 83%

“…The findings in bipolar disorder are summarized succinctly by a meta-analysis that reports low phosphomonoesters in euthymic patients relative to control subjects, whereas phosphomonoesters were elevated in bipolar patients who were primarily depressed (103). Phosphodiesters showed no differences between patients and controls (103).…”

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confidence: 99%

MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases

Mason

Krystal

2006

NMR Biomed.

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Magnetic resonance spectroscopy (MRS) is likely in the near future to play a key role in the process of drug discovery and evaluation. As the pharmaceutical industry seeks biochemical markers of drug delivery, efficacy and toxicity, this non-invasive technique offers numerous ways to study adults and children repeatedly and without ionizing radiation. In this article, we survey an array of the information that MRS offers about neurochemistry in general and psychiatric disorders and their treatment in particular. We also present growing evidence of glial abnormalities in neuropsychiatric disorders and discuss what MRS is contributing to that line of investigation. The third major direction of this article is the discussion of where MRS techniques are headed and how those new techniques can contribute to studies of mechanisms of psychiatric disease and drug discovery.

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31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis

Cited by 77 publications

References 37 publications

Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research

Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research

The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases

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