308-nm excimer laser therapy in alopecia areata

Zakaria, Wassim; Passeron, Thierry; Ostovari, Nima; Lacour, Jean‐Philippe; Ortonne, Jean‐Paul

doi:10.1016/j.jaad.2004.05.026

Cited by 77 publications

(79 citation statements)

References 5 publications

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“…The mean age of the patients was 45.7 AE 16.9 years (range, 24-66) and the mean disease duration was 9.3 AE 8.1 years (range, 1-22). The treatments administrated to the patients included topical steroids (mean, 25 months; range, 3-60), infrared therapy (mean, 15.8 months; range, 9-30), topical immunotherapy (mean, 15.4 months; range, 7-29), corticosteroid pulse therapy and cryotherapy (mean, 11 months; range, [6][7][8][9][10][11][12][13][14][15][16]. In all cases, hair loss that extended beyond the scalp was used to confirm the diagnosis of AU.…”

Section: Methodsmentioning

confidence: 99%

“…The severity of the patients' AA was graded based on the severity of alopecia tool (SALT) score, which was assessed according to the Alopecia Areata Investigational Assessment Guidelines -Part II. 6 A SALT score of more than 70 (70% regrowth) was regarded as good, a SALT score of more than 10 (10% regrowth) but less than 70 was considered to be poor, and a SALT score of less than 10 was defined as no response.…”

Section: Treatment Evaluationmentioning

confidence: 99%

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Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Arakawa

Nomiyama

Katoh

2016

The Journal of Dermatology

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Three hundred and eight nanometer excimer light therapy has recently been reported to be effective against patchy alopecia areata (AA) in several clinical studies. However, these studies only included a few patients with severe forms of AA, and all of them exhibited poor outcomes. We further investigated the use of excimer light as a therapeutic option for cases of alopecia universalis (AU) that are resistant to other treatments. Eleven treatmentresistant AU patients were treated with a 308-nm excimer light at 2-week intervals for more than 16 sessions. Four patients achieved good responses and two patients exhibited poor responses. Three patients had Japanese skin type 1 and all of them achieved good responses. The radiation dose was increased until the patients exhibited marked erythema. The patients with Japanese skin type 3 who achieved good responses exhibited strong pigmentation at the irradiated sites. In conclusion, 308-nm excimer light therapy has significant effects on some AU patients who are resistant to other treatments and may be an alternative therapeutic option for AU. During the treatment of AU, high doses of radiation should be administrated until a strong inflammatory skin reaction is seen.

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Section: Methodsmentioning

confidence: 99%

Section: Treatment Evaluationmentioning

confidence: 99%

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Arakawa

Nomiyama

Katoh

2016

The Journal of Dermatology

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“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Recently, the use of biologics and laser therapy in alopecia areata have shown some beneficial results. [21][22][23] There has been a recent spurt in application of platelet-rich plasma (PRP) in dermatology and aesthetic medicine. 24 Overall, PRP seems to be a promising therapeutic modality but the level of evidence as of now, from the available published data is low.…”

Section: Introductionmentioning

confidence: 99%

A clinical study on alopecia areata

Ninama¹,

Mahajan²,

Bilimoria³

et al. 2018

Int J Res Dermatol

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Background: Alopecia areata (AA) is a common auto-immune condition, causing hair loss. This disease has limited treatment modalities. Through this study, comparison between established modalities of treatment such as oral mini pulse therapy, intralesional corticosteroids and platelet-rich plasma (PRP) as a newer modality has been done. The objective of the study was to evaluate the efficacy and safety of various treatment modalities in alopecia areata.Methods: 45 patients with alopecia areata presenting to the OPD of Dermatology, Dhiraj hospital, Pipariya were included in this study. It was conducted as a randomized prospective study for a period of 16 weeks. After taking informed consent, patients were randomly distributed into three treatment groups. Group 1 patients were treated with Tab. Betamethasone 0.1 mg/kg every Saturday and Sunday, Group 2 was treated with Inj. Triamcinolone acetonide 10 mg/ml for scalp and 2.5 mg/ml for eye brows and face was injected into deep dermis; Group 3 was treated with Dermaroller followed by application of activated platelet rich plasma (PRP). SALT score was calculated at first visit and 16 weeks. Regrowth was calculated using Mac Donald and Null Horis grading Scale at 16 weeks.Results: The SALT score reduced from 13.27 to 7.52 in Group 1, 13.93 to 8.16 in Group 2 and 42.32 to 21.12 in Group 3. Mean grade of regrowth of hairs observed was 3.47, 3.80, 2.93 in Group 1, 2, 3 respectively. The results were analysed using paired t test.Conclusions:Intralesional corticosteroids viz. triamcinolone acetonide still remains the first choice of therapy for AA in adults with limited involvement. Systemic corticosteroids give lower response than intralesional steroids. Platelet Rich Plasma (PRP) showed promising results, especially in children and in extensive involvement. Compared to other treatment modalities Inj. PRP is safe and with less side effects.

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“…Since the benefit of the excimer laser on AA first reported by Gundogan et al, 20 numerous studies have confirmed its efficacy. [21][22][23] The largest study so far was done on 18 patients with recalcitrant AA that involved the scalp, beard, arms and legs. Each alopecic patch was treated twice a week for a maximum of 24 sessions.…”

Section: -Nm Excimer Lasermentioning

confidence: 99%

“…22 Although all studies have reported the efficacy of excimer laser in AA, the therapeutic results seem to be poor in patients with alopecia universalis and alopecia totalis, 21 in which no hair regrowth was observed in patches on the extremities. 22 Also, atopic diathesis had been found to a poor prognostic factor, as patients with atopic diseases had shown minimal responses to the therapy.…”

Section: -Nm Excimer Lasermentioning

confidence: 99%

Use of Lasers in the Treatment of Alopecia Areata

Chu

Kim

2016

Medical Lasers

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Alopecia areata (AA) is a complex autoimmune disease characterized by round or oval patches of non-scarring hair loss that is mediated by lymphocytes affecting the hair follicles. To treat localized AA, intralesional corticosteroid injections and topical corticosteroids are most commonly used, while for widespread AA, systemic steroids, immunosuppresants, and contact immunotherapy are commonly considered. However, therapeutic options for refractory AA that is unresponsive to these conventional treatments are limited. Various lasers have been suggested in recent studies to treat AA. The effect of 308-nm excimer laser was the most studied, while others, including neodymium-doped yttrium aluminum garnet, erbium:glass laser, fractional CO2 laser, and low-level laser therapy, have also been assessed. Despite the nascent state of research on lasers as a treatment option for AA, there have been a great deal of promising results. It is possible for lasers to become the mainstay treatment option of AA. Key words

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308-nm excimer laser therapy in alopecia areata

Cited by 77 publications

References 5 publications

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

A clinical study on alopecia areata

Use of Lasers in the Treatment of Alopecia Areata

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