Clinical, Laboratory and Imaging Features of High Altitude Pulmonary Edema in Tibetan Plateau

Li, Zongbin; Chen, Liqun; Li, Jiayue; Li, Gao-Yuan; Liu, Chunwei; Chen, Yundai

doi:10.24920/11813

Cited by 9 publications

(2 citation statements)

References 21 publications

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“… 18 – 20 Predominantly unilateral radiographic involvement was variably reported from 15 to 60%. 9 – 11 Right lung predilection and predominance were shown in patients with unilateral and bilateral edema, respectively. 9 , 11 Since HAPE presenting as unilobar or multilobar consolidation is rare, it is imperative to be aware of such a radiological picture ( Figs.…”

Section: Discussionmentioning

confidence: 98%

“…Bilateral diffuse opacities is a common manifestation of HAPE seen in up to 40% patients by Vock et al, 81% patients by Li et al, and 85% patients by Kobayashi et al 9 – 11 Airspace opacification is sharply confined to central, perihilar regions of the lung with sparing of peripheral or subpleural regions in early cases and extending to the periphery in severe cases. 12 , 13 It is essential to rule out differentials as all the patients with bilateral diffuse radiological opacities at HA need not be HAPE, as was reported in a patient of systemic lupus erythematosus with diffuse alveolar hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

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Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay

Yanamandra

Vardhan

Saxena

et al. 2021

Indian Journal of Critical Care Medicine

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A bstract Background High-altitude pulmonary edema (HAPE) is a common cause of hospitalization in high altitude areas with significant morbidity. The clinical presentation of HAPE can overlap with a broad spectrum of cardiopulmonary diseases. Also, it is associated with varied radiological manifestations mimicking other conditions and often leading to unnecessary and inappropriate treatment. Patients and methods The primary aim of the study was to study the various radiological manifestations of HAPE through real-world chest radiographs. We present six different chest X-ray patterns of HAPE as a pictorial assay, at initial presentation, and after the resolution of symptoms with supplemental oxygen therapy and bed rest alone. Results HAPE can present as bilateral symmetrical perihilar opacities, bilateral symmetrical diffuse opacities, unilateral diffuse opacities, bilateral asymmetrical focal opacities, and even lobar consolidation with lower zone or less commonly upper zonal predilection. These presentations can mimic many common conditions like heart failure, acute respiratory distress syndrome, pulmonary embolism, aspiration pneumonitis, pneumonia, malignancy, and tuberculosis. Conclusion A holistic clinical–radiological correlation coupled with analysis of the temporal course can help high-altitude physicians in differentiating true HAPE from its mimics. How to cite this article Yanamandra U, Vardhan V, Saxena P, Singh P, Gupta A, Mulajkar D, et al . Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay. Indian J Crit Care Med 2021;25(6):668–674.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay

Yanamandra

Vardhan

Saxena

et al. 2021

Indian Journal of Critical Care Medicine

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Pediatric high‐altitude pulmonary edema and acute mountain sickness: Clinical features and risk determinants

Mi,

Hu,

Chao

et al. 2024

Pediatric Pulmonology

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ObjectiveThis investigation aimed to delineate the clinical manifestations associated with high‐altitude pulmonary edema (HAPE) and acute mountain sickness (AMS) in pediatric populations and find the risk factors of HAPE.MethodsWe conducted a retrospective analysis of clinical data from children under 18 years diagnosed with HAPE and AMS at an average altitude of 3000 m. The clinical data between these two groups were compared.ResultsThe study encompassed 74 pediatric patients, 27 with AMS and 47 with HAPE. HAPE presentations included classic HAPE (55.3%), reentry HAPE (27.7%), and high‐altitude resident pulmonary edema (HARPE, 17.0%). Notably, 87.2% of HAPE cases were male, and 68.1% had a high body mass index (BMI). HARPE instances followed viral infections, prominently SARS‐CoV‐2. HAPE cases exhibited higher BMI, respiratory tract infections within 1 week preceding symptom onset, an increase in white blood cell counts (WBCs), lower peripheral arterial oxygen saturation (SpO2), and higher heart rate compared to the AMS group. Multivariate logistic regression pinpointed high BMI as an independent HAPE risk factor (odds ratio = 19.389, 95% confidence interval: 1.069–351.759, p = .045).ConclusionHAPE occurs predominantly in males, with high BMI identified as a critical independent risk factor. The study underscores the need for heightened awareness and preventive strategies against HAPE in children at high altitudes.

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Characteristics of High Altitude Pulmonary Edema in Naqu at the Altitude of 4500 m

Lv²,

He³

et al. 2021

The American Journal of the Medical Sciences

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Clinical, Laboratory and Imaging Features of High Altitude Pulmonary Edema in Tibetan Plateau

Cited by 9 publications

References 21 publications

Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay

Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay

Pediatric high‐altitude pulmonary edema and acute mountain sickness: Clinical features and risk determinants

Characteristics of High Altitude Pulmonary Edema in Naqu at the Altitude of 4500 m

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