New Insights into the Role of Trace Elements in IBD

Gîlcă-Blanariu, Georgiana-Emmanuela; Diaconescu, Smaranda; Ciocoiu, Manuela; Ştefănescu, Gabriela

doi:10.1155/2018/1813047

Cited by 41 publications

(30 citation statements)

References 96 publications

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“…28 These previous studies are reminiscent of the findings described here for Mn, as deficiencies in these other trace minerals also show effects on the intestinal barrier and immune functions. 25 One striking feature of Mn deficiency was its impact on the severity of DSS-induced colitis. Previous studies using Se-deficient diets (<0.01 mg/kg) showed that a time period of 12 weeks was required before Se deficiency resulted in any worsening in the colons of DSS-induced colitis in mice.…”

Section: Discussionmentioning

confidence: 99%

“…Micronutrient deficiencies have been, for decades, a major concern in the management of IBD as numerous studies have documented associations between IBD and deficiencies in trace minerals, such as Fe, Zn, and Se. 25 Fe deficiency is associated with the bleeding, malabsorption, or anemia that occurs in one-third of IBD patients, 26 while zinc deficiency is also common in patients with IBD (15 to 40% of the patient population). 27 Similarly, an inverse association has been reported for nutritional Se status and the occurrence of IBD.…”

Section: Discussionmentioning

confidence: 99%

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Impact of dietary manganese on experimental colitis in mice

et al. 2019

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Diet plays a significant role in the pathogenesis of inflammatory bowel disease (IBD). A recent epidemiological study has shown an inverse relationship between nutritional manganese (Mn) status and IBD patients. Mn is an essential micronutrient required for normal cell function and physiological processes. To date, the roles of Mn in intestinal homeostasis remain unknown and the contribution of Mn to IBD has yet to be explored. Here, we provide evidence that Mn is critical for the maintenance of the intestinal barrier and that Mn deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice. Specifically, when treated with DSS, Mn-deficient mice showed increased morbidity, weight loss, and colon injury, with a concomitant increase in inflammatory cytokine levels and oxidative and DNA damage. Even without DSS treatment, dietary Mn deficiency alone increased intestinal permeability by impairing intestinal tight junctions. In contrast, mice fed a Mn-supplemented diet showed slightly increased tolerance to DSS-induced experimental colitis, as judged by the colon length. Despite the well-appreciated roles of intestinal microbiota in driving inflammation in IBD, the gut microbiome composition was not altered by changes in dietary Mn. We conclude that Mn is necessary for proper maintenance of the intestinal barrier and provides protection against DSS-induced colon injury. K E Y W O R D Scolitis, gut microbiota, inflammatory bowel disease, manganese, tight junction 2930 | CHOI et al. | RNA isolation and RT-PCR

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of dietary manganese on experimental colitis in mice

et al. 2019

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“…IBD is characterized by ongoing chronic inflammation, which generates, among others, oxidative stress. Selenium deficiency has been demonstrated during both exacerbation and remission in patients with UC and CD [83]. Researchers describe selenium deficiencies in patients with CD, which may lead to the reduction of the body's immune response to the development of inflammation.…”

Section: Zinc Zinc Is a Food Component Classed As A Micronutrientmentioning

confidence: 99%

The Influence of Nutrients on Inflammatory Bowel Diseases

Jarmakiewicz-Czaja

Piątek

Filip

2020

Journal of Nutrition and Metabolism

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Inflammatory bowel diseases is a group of inflammatory diseases. e pathogenesis of diseases is multifactorial, which may include a Western-type diet. Diseases occur with periods of recurrence and remission. Many factors can have a beneficial effect on reducing the frequency of recurrence and prolonging the remission period. Such ingredients include dietary fibre, mono-and polyunsaturated fatty acids, certain vitamins (D, C, and E), flavonoids, and minerals such as zinc and selenium. Properly selected nutrition might be an integral part of the treatment of patients with Crohn's disease or ulcerative colitis.

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“…Of those, however, Cu and Fe, if not protein-bound, interact with hydrogen peroxide and produce hydroxyl radical in Fenton reaction, exacerbating rather than attenuating the oxidative stress. Accordingly, an increased Cu/Zn ratio accompanies inflammatory and oxidative stress conditions [79]. Although the evidence on the role of micronutrients in the pathogenesis of IBD is limited, two large prospective studies have demonstrated that zinc intake is associated with decreased risk of CD but not UC [80].…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 99%

“…Malnutrition accompanying some IBD patients, particularly those with CD, may either cause or exacerbate the existing deficiencies. Indeed, the estimates on the prevalence of zinc deficiency among IBD patients differ from 14% to even 40% [79]. Our literature screening retrieved only a few papers, in which Se and Zn have been assessed.…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 99%

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

et al. 2020

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Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted. Out of 874 articles, 79 eligible studies were identified and used to prepare the interpretative synthesis. Antioxidants followed by lipid peroxidation markers were the most popular and markers of oxidative DNA damage the least popular. There was a disparity in the number of retrieved papers evaluating biomarkers in the adult and pediatric population (n = 6). Of the reviewed OSMs, a promising performance has been reported for serum total antioxidant status as a mucosal healing marker, mucosal 8-OHdG as a progression marker, and for multi-analyte panels of lipid peroxidation products assessed non-invasively in breath as diagnostic and differential markers in the pediatric population. Bilirubin, in turn, was the only validated marker. There is a desperate need for non-invasive biomarkers in IBD which, however, will not be met in the near future by oxidative stress markers as they are promising but mostly at the early research phase of discovery.

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New Insights into the Role of Trace Elements in IBD

Cited by 41 publications

References 96 publications

Impact of dietary manganese on experimental colitis in mice

Impact of dietary manganese on experimental colitis in mice

The Influence of Nutrients on Inflammatory Bowel Diseases

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

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