The orofacial antinociceptive effect of Kaempferol-3-O-rutinoside, isolated from the plant Ouratea fieldingiana, on adult zebrafish (Danio rerio)

Nascimento, José Eranildo Teles do; Morais, Selene Maia de; Lisboa, Daniele Silva de; Sousa, Matheus de Oliveira; Santos, Sacha Aubrey Alves Rodrigues; Magalhães, Francisco Ernani Alves; Campos, Adriana Rolim

doi:10.1016/j.biopha.2018.08.089

Cited by 42 publications

(14 citation statements)

References 38 publications

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“…30 A previous animal (mouse) study on the evaluation of acute toxicity reported that doses of 100 mg/kg/ day, administered orally for 27 weeks, did not cause hematological or tissue changes. 31 This evidence stimulates further pharmacological investigations of genariol, including its analgesic effect.…”

Section: Discussionmentioning

confidence: 79%

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

et al. 2020

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We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and vehicle (saline + Tween 80 at 0.2%, i.p.) 30 minutes prior to the beginning of the experiment. Injecting glutamate (25 μM), capsaicin (2.5 μg) and formalin (2%) into the right upper lip (perinasal) of the mouse induced nociception. Behavioral analysis of the animals considered the friction time (in seconds) of the mentioned region using hind or front paws by a researcher blinded to the treatment groups. The statistical analysis was performed blindly, considering α = 5%. The results showed that in the glutamate and capsaicin tests, concentrations of 25 mg/kg and 50 mg/ kg presented antinociceptive activity (p < 0.005, power> 80%). In the formalin test, geraniol was able to reduce nociception at a concentration of 50 mg/kg (p < 0.005, power> 80%). In the molecular anchorage study, high values of binding between the evaluated substance and receptors of glutamate were observed (metabotropic glutamate receptor,-87.8501 Kcal/mol; N-methyl-D-aspartate,-86.4451 Kcal/mol; α-amino-3hydroxy-5-methyl-4-isoxazole propionic acid,-85.6755 Kcal/mol). Geraniol presented orofacial antinociceptive activity, probably by interacting with glutamate-related receptors.

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Section: Discussionmentioning

confidence: 79%

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

et al. 2020

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“…Alkaloids and flavonoids have also been implicated in analgesic and anti-inflammatory activities of extracts from stem wood of Pterocarpus marsupium 20 . An orofacial antinociceptive effect in zebra fish (Danio rerio) has been observed with kaempferol-3-O-rutinoside, isolated from the plant Ouratea fieldingiana 21 . Methanolic extract of barks of Himalrandia tetrasperma and Wendlandia exserta reportedly showed analgesic effects in hot plate analgesic assays in mice; the extracts contained alkaloids and flavonoids 22 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Analgesic Activity of Bulbophyllum Neilgherrense Wight (Orchidaceae)

Zubair¹,

Hossain²,

Mahbub³

et al. 2019

Int. J. Res. Ayurveda Pharm.

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Background: Bulbophyllum neilgherrense is considered a medicinal orchid in Bangladesh and south India, the pseudobulb being used to treat leucoderma. However, the plant has not been studied scientifically to any large extent. It was the objective of the present study to evaluate the analgesic activity of methanol extract of the whole plant. Materials and Methods: Analgesic activity was studied by the acetic acid-induced writhing method in Swiss albino mice. Results: Methanolic extract of B. neilgherrense (MEBN), when administered to mice in acetic acid-induced writhing tests dosedependently reduced the number of writhings (constrictions). At doses of 50, 100, 200 and 400 mg per kg body weight MEBN reduced the number of writhings, respectively, by 23.5, 41.2, 50.0 and 67.6%. By comparison, a standard analgesic drug, aspirin reduced the number of writhings by 41.2 and 67.6%, respectively at doses of 200 and 400 mg per kg body weight. Conclusion: The results indicate that B. neilgherrense methanolic extract can effectively reduce pain in a manner comparable to that of aspirin. The results further suggest that the plant may prove to be a good source of painalleviating compound(s).

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“…As a result, these tests were used as screening tests to investigate new drugs, including drugs derived from natural products and plants, for example, refs. [62,63]. These tests have also been used to study the neural mechanisms of anxiety-like behavior [64][65][66][67][68].…”

Section: Behavioral Models In Zebra Fishmentioning

confidence: 99%

New Developments in Behavioral Pharmacology

Cueto‐Escobedo¹,

García-García²,

Maximino³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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Behavioral pharmacology research has been a cornerstone in the understanding of the processes that underlie the behavior of living organisms as well as the biological basis of the behavioral, emotional, and cognitive disorders that affect humans. The findings in this area have helped to explore the potential therapeutic effects of several substances for the treatment of the mentioned disorders. The present chapter brings an extremely brief introduction to this vast area. First, we try to put in context behavioral pharmacology and its relevance and then show some brief examples of how this discipline has developed over the years. Second, we review the concept of a "research model" in preclinical behavioral pharmacology, given the importance of animal models and tests in this area, followed by a brief review of the recent advances using zebra fish as a valuable tool of research. Third, more specific examples are aborded, such as the findings on sleep disorders and those related to sexual hormones and menopause.

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The orofacial antinociceptive effect of Kaempferol-3-O-rutinoside, isolated from the plant Ouratea fieldingiana, on adult zebrafish (Danio rerio)

Cited by 42 publications

References 38 publications

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

Evaluation of Analgesic Activity of Bulbophyllum Neilgherrense Wight (Orchidaceae)

New Developments in Behavioral Pharmacology

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