Corrigendum to “Immunocompetent Mice Model for Dengue Virus Infection”

Gonçalves, Denise; Prado, Rafael de Queiroz; Xavier, Eric Almeida; Oliveira, Natália Cristina de; Guedes, Paulo Marcos da Matta; Silva, João; Figueiredo, Luíz Tadeu Moraes; Aquino, Víctor Hugo

doi:10.1155/2018/5268929

Cited by 8 publications

(12 citation statements)

References 1 publication

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“…The peak of viremia coincided with decreased platelet levels. Throughout the infection, mice had increased AST and ALT as well as immune infiltration in liver and increased Th1 associated cytokines IL‐12 and IL‐18 33 . The present study reports a number of markers of disease in C57BL/6 pups shared by C57BL/6 adults, such as increased liver enzymes accompanied by immune infiltrates and viral dissemination to liver and kidney.…”

Section: Discussionsupporting

confidence: 52%

“…Concerning our model of DENV primary infection, C57BL/6 pups exhibited a Th1 bias evidenced by a 6‐fold higher IFN‐γ/IL‐4 ratio compared to BALB/c pups. Increased Th1 cytokines have also been detected in adult C57BL/6 mice after DENV primary infection 32,33 and a role for IFN‐γ in resistance against infection has been reported 32 …”

Section: Discussionmentioning

confidence: 99%

“…Newer models have recapitulated some aspects of disease in non‐IFN‐based immunodeficiencies or have used humanized mouse models 29 . Some aspects of primary infection, including enzymatic and biochemical alterations and tissue damage have been modeled in immunocompetent C57BL/6 mice infected with mouse adapted‐DENV and some clinical isolates 32‐35 . Another study documented increased vascular permeability and a platelet reduction in C57BL/6 mice infected with a DENV clinical isolate 36,37 .…”

Section: Introductionmentioning

confidence: 99%

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A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice

Byrne

García

Brahamian

et al. 2020

Anim Models and Exp Med

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Dengue is a significant public health concern across tropical and subtropical regions worldwide, principally causing disease in children. Very young children are at increased risk of severe manifestations of dengue infection. The mechanism of dengue disease in this population is not fully understood. In this study, we present a murine model of dengue virus primary infection in suckling C57BL/6 and BALB/c mice in order to investigate disease pathogenesis. Three‐day‐old C57BL/6 mice intraperitoneally infected with DENV‐2 NGC were more susceptible to infection than BALB/c mice, showing increased liver enzymes, extended viremia, dissemination to organs and histological alterations in liver and small intestine. Furthermore, the immune response in DENV‐infected C57BL/6 mice exhibited a marked Th1 bias compared to BALB/c mice. These findings highlight the possibility of establishing an immunocompetent mouse model of DENV‐2 infection in suckling mice that reproduces certain signs of disease observed in humans and that could be used to further study age‐related mechanisms of dengue pathogenesis.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice

Byrne

García

Brahamian

et al. 2020

Anim Models and Exp Med

View full text Add to dashboard Cite

show abstract

“…Moreover, severe disease manifestations with increased lethality were observed in IFN-γ(-/-) mice, suggesting that IFN-γ plays a role in resistance to DENV infection [27]. It has also been shown that IP inoculation of C57BL/6 mice with DENV-1 results in viremia, and produces signs of dengue, such as thrombocytopenia, spleen hemorrhage, liver damage, and increased production of IFN-γ and TNF-α [34].…”

Section: Mouse Modelsmentioning

confidence: 99%

Mammalian animal models for dengue virus infection: a recent overview

Kayesh

Tsukiyama-Kohara

2021

Arch Virol

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Dengue, a rapidly spreading mosquito-borne human viral disease caused by dengue virus (DENV), is a public health concern in tropical and subtropical areas due to its expanding geographical range. DENV can cause a wide spectrum of illnesses in humans, ranging from asymptomatic infection or mild dengue fever (DF) to life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Dengue is caused by four DENV serotypes; however, dengue pathogenesis is complex and poorly understood. Establishing a useful animal model that can exhibit dengue-fever-like signs similar to those in humans is essential to improve our understanding of the host response and pathogenesis of DENV. Although several animal models, including mouse models, non-human primate models, and a recently reported tree shrew model, have been investigated for DENV infection, animal models with clinical signs that are similar to those of DF in humans have not yet been established. Although animal models are essential for understanding the pathogenesis of DENV infection and for drug and vaccine development, each animal model has its own strengths and limitations. Therefore, in this review, we provide a recent overview of animal models for DENV infection and pathogenesis, focusing on studies of the antibody-dependent enhancement (ADE) effect in animal models.

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“…In nature peptides have fantastic functions and capabilities, they build adaptable viral across species [1] and prions pathogens that cause a group of fatal neurodegenerative diseases by transmissible mechanism that are devoid of nucleic acid [2].…”

Section: Introductionmentioning

confidence: 99%

An in vitro test of new peptide against melanoma

Xavier¹

2022

World J. Adv. Res. Rev.

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Peptides have fantastic functions like prions pathogens that cause transmissible diseases devoid of nucleic acid. Furthermore, because of their high specificity, peptides can be used in antitumor therapy to target specific targets. In this work we describe the in vitro antitumor action against B16F10 cells of a peptide named W12K obtained from immunoglobulin gene. As a result, we showed antitumor growing in experimental trials such as viability, migration, and cell cycle. In conclusion the present article describes a molecule from immunoglobulin with future potential for in vivo therapeutic test.

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Corrigendum to “Immunocompetent Mice Model for Dengue Virus Infection”

Cited by 8 publications

References 1 publication

A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice

A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice

Mammalian animal models for dengue virus infection: a recent overview

An in vitro test of new peptide against melanoma

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