Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study

Park, Song‐Yi; Wilkens, Lynne R.; Setiawan, Veronica Wendy; Monroe, Kristine R.; Haiman, Christopher A.; Marchand, Loı̈c Le

doi:10.1093/aje/kwy208

Cited by 39 publications

(33 citation statements)

References 18 publications

(23 reference statements)

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“…In the United States, hardly anyone starts to smoke after age 50 years, which is similar to our minimum enrollment age of 45 years ( 9 ). Furthermore, we have previously demonstrated the internal validity of the smoking exposure variables ( 39–41 ) and associations with other lifestyle factors (dietary fiber intake, MHT, and alcohol consumption) and the CRC outcome ( 42 , 43 ). We had detailed information on, and were able to control for, the established risk factors for CRC, many of which vary according to smoking status.…”

Section: Discussionmentioning

confidence: 99%

Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex

Gram

Park

Wilkens

et al. 2020

American Journal of Epidemiology

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The purpose of this study was to examine whether the increased risk of colorectal cancer due to cigarette smoking differed by anatomical subsite or sex. We analyzed data from 188,052 participants aged 45–75 years (45% men) who were enrolled in the Multiethnic Cohort Study in 1993–1996. During a mean follow-up period of 16.7 years, we identified 4,879 incident cases of invasive colorectal adenocarcinoma. In multivariate Cox regression models, as compared with never smokers of the same sex, male ever smokers had a 39% higher risk (hazard ratio (HR) = 1.39, 95% confidence interval (CI): 1.16, 1.67) of cancer of the left (distal or descending) colon but not of the right (proximal or ascending) colon (HR = 1.03, 95% CI: 0.89, 1.18), while female ever smokers had a 20% higher risk (HR = 1.20, 95% CI: 1.06, 1.36) of cancer of the right colon but not of the left colon (HR = 0.96, 95% CI: 0.80, 1.15). Compared with male smokers, female smokers had a greater increase in risk of rectal cancer with number of pack-years of smoking (P for heterogeneity = 0.03). Our results suggest that male smokers are at increased risk of left colon cancer and female smokers are at increased risk of right colon cancer. Our study also suggests that females who smoke may have a higher risk of rectal cancer due to smoking than their male counterparts.

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Section: Discussionmentioning

confidence: 99%

Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex

Gram

Park

Wilkens

et al. 2020

American Journal of Epidemiology

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“…This study confirmed alcohol consumption as a risk factor for colorectal cancer by investigating their association with one another according to ethnicity, sex, lifestyle components, and types of alcoholic drinks. The results showed that those who consumed more than 30g of alcohol a day increased risk to those who consumed 15-29.9g per day (Park et al, 2019). In addition, the findings stated that beer and wine consumption was directly related to increased colorectal cancer risk, except for liquor.…”

Section: Colon-rectal Cancermentioning

confidence: 88%

“…Many studies have focused on alcoholism and the risk of colon rectal carcinoma (Park et al, 2019). The main metabolite of ethanol is acetaldehyde, which is carcinogenic (Mármol et al, 2017).…”

Section: Colon-rectal Cancermentioning

confidence: 99%

Narrative Literature Review on Risk Factors Involved In Breast Cancer, Brain Cancer, Colon Rectal Cancer, Gynecological Malignancy, Lung Cancer, and Prostate Cancer<strong> </strong>

Justiz-Vaillant¹,

Gardiner²,

Mohammed³

et al. 2021

Preprint

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In this study, we describe the most critical risk factors for different malignancies, including breast, prostate, lung, colon-rectal carcinoma, among others and those with risk factors that are modifiable. We revised the literature review about risk factors involved in the genesis of cancer in various databases, including articles indexed in PUBMED, SCOPUS, PMC, and Google Scholar. Knowing risk factors is a mode of fighting malignancy. Diet, lifestyle, practises, and laboratory/clinical interventions were among risk factors of diverse malignancy. We conclude that risk factors can prevent the development of many malignancies in a century where this conundrum is raising disproportionably. It is treated here is to make the public aware of the modifiable risks of cancers.

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“…Many studies have focused on alcoholism and the risk of colorectal carcinoma [38]. The main metabolite of ethanol is acetaldehyde, which is carcinogenic [35].…”

Section: Colorectal Cancermentioning

confidence: 99%

Narrative Literature Review on Risk Factors Involved in Lung Cancers, Breast Cancers, Brain Cancers, Gastrointestinal Cancers, Gynecologic Cancers, and Urogenital Cancers

Vaillant

Gardiner

Mohammed

et al. 2021

JCTI

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In this study, we described the most critical risk factors for different malignancies including breast, prostate, lung, and colorectal carcinoma among others, with an emphasis on modifiable risk factors. We revised the literature review about risk factors involved in the genesis of cancer in various databases, including articles indexed in PUBMED, SCOPUS, PMC, and Google Scholar. Awareness of risk factors enables conscious decisions to be made in an effort to combat malignancies. Knowing risk factors is a mode of fighting malignancy. Diet, lifestyle, practises, and laboratory/clinical interventions were among risk factors of diverse malignancy. Diet, lifestyle, laboratory/clinical interventions all contribute to the genesis and prognosis in a variety of malignancies. We concluded that abstaining from risk factors can prevent the development of many malignancies in a century where this conundrum is raising disproportionately. By informing the public about modifiable risk factors cancer mortality rates can be reduced. It is treated here is to make the public aware of the modifiable risks of cancers.

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Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study

Cited by 39 publications

References 18 publications

Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex

Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex

Narrative Literature Review on Risk Factors Involved In Breast Cancer, Brain Cancer, Colon Rectal Cancer, Gynecological Malignancy, Lung Cancer, and Prostate Cancer<strong> </strong>

Narrative Literature Review on Risk Factors Involved in Lung Cancers, Breast Cancers, Brain Cancers, Gastrointestinal Cancers, Gynecologic Cancers, and Urogenital Cancers

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