Analysis of ocular inflammation in anterior chamber—involving uveitis using swept-source anterior segment OCT

Baghdasaryan, Elmira; Tepelus, Tudor; Marion, Kenneth M.; Huang, Jianyan; Huang, Ping; Sadda, Srinivas R.; Lee, Olivia L

doi:10.1007/s10792-018-1005-0

Cited by 16 publications

(16 citation statements)

References 19 publications

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“…In recent studies, it was demonstrated that there is a significant correlation between the number of anterior chamber cells on OCT and the grade of anterior chamber cells on slit-lamp biomicroscopy. 6,10,12,[14][15][16]25 This study revealed the value of OCT for cell evaluation based on the significant correlation between slit lamp-based cell scores and OCT cell counts, although the cell grade through the slit-lamp biomicroscopy was not detailed. In addition, the SD-OCT used in this study had a sufficiently high resolution to capture anterior chamber cells in dogs.…”

Section: Discussionmentioning

confidence: 84%

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The feasibility of clinical evaluation for anterior uveitis through spectral‐domain optical coherence tomography in dogs

Jeong

Kang

Shim

et al. 2021

Veterinary Ophthalmology

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Objective: To evaluate the clinical application of spectral-domain optical coherence tomography (SD-OCT) for anterior uveitis in dogs. Animals and procedures:Client-owned dogs presenting with anterior uveitis and clinically healthy dogs were enrolled in this study. Included eyes were divided into 5 groups by flare grade and 3 groups by cell grade through slit-lamp biomicroscopy. Each eye was examined using SD-OCT following slit-lamp biomicroscopy. The ratio of aqueous signal intensity to air signal intensity, which is called the aqueous-to-air relative intensity (ARI) index, was used to evaluate the flare grade. Cell number, central corneal thickness (CCT), and the presence of keratic precipitates (KPs) were analyzed on SD-OCT. The OCT parameters, including ARI index, cell number, and CCT, were compared to the slit-lamp clinical flare and cell grade.Results: Thirty-six eyes with anterior uveitis and 27 healthy eyes were enrolled. The ARI index showed a significant correlation with clinical flare grade (r s = 0.811, p < .001). In multiple regression analysis, the ARI index and CCT showed a significant negative correlation (r = −0.258, p = .044). The number of cells on SD-OCT significantly increased with cell grade on slit-lamp biomicroscopy (r s = 0.653, p < .001). The clinical flare grade and CCT were significantly correlated in the partial correlation analysis after controlling for age (partial correlation coefficient = 0.471, p = .002). KPs were observed in 61% of the eyes with flare using SD-OCT (22/36 eyes).Conclusions: Spectral-domain optical coherence tomography could provide quantitative information, including the ARI index, cell counts, and CCT in dogs. SD-OCT is an auxiliary modality for slit-lamp biomicroscopy when evaluating anterior uveitis in dogs.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

The feasibility of clinical evaluation for anterior uveitis through spectral‐domain optical coherence tomography in dogs

Jeong

Kang

Shim

et al. 2021

Veterinary Ophthalmology

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“…2017; Baghdasaryan et al. 2019). Manual and automated segmentation seemed equivalent in previous reports, though, automated algorithms can be easily developed, enhancing reliability (Agarwal et al.…”

Section: Discussionmentioning

confidence: 99%

“…2017; Baghdasaryan et al. 2019). Even though stronger correlation between OCT cell counts and ACC grading (SUN) has been found in HLA‐B27 acute anterior uveitis than in other forms of uveitis (Igbre et al.…”

Section: Discussionmentioning

confidence: 99%

Swept‐source optical coherence tomography objective composite activity score for uveitis

Llorenç

Serrano

Mesquida

et al. 2021

Acta Ophthalmologica

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Purpose To develop an objective intraocular inflammation composite score. Methods Cross‐sectional study. Non‐invasive image acquisition and processing were conducted from April 2017 to April 2019. Inflammation‐grade stratified eyes from patients with active, inactive uveitis and healthy controls were recruited. After clinical assessment, four anterior and posterior segment image acquisition protocols per eye, using swept‐source optical coherence tomography (SS‐OCT), were performed at inclusion. Eight imaging biomarkers in three domains: anterior, intermediate and posterior were studied. They were ranked and selected by discriminatory power and correlation with clinical scores. A final SS‐OCT‐derived composite uveitis activity score (SS‐UAS) was developed through multiple linear regression. Results We studied 224 eyes with uveitis (165 active and 59 inactive) from 165 patients (mean age 46.6 SD 15.5 years; 55.3% women) and 38 eyes from 19 healthy controls (mean age 43.6 SD 17.1; 47% women). The selected SS‐OCT‐derived biomarkers to build the final score were anterior chamber hyper‐reflective dots (anterior), high‐definition relative vitreous intensity (intermediate) and the averaged thickened retinal index (posterior). Swept‐source (SS)‐UAS was highly discriminant between active and inactive, and between active and healthy eyes (means 2.06 SD 1.86, 0.93 SD 0.44, and 0.96 SD 0.38, respectively, both p ‐, Mann–Whitney U). Construct validity (Cronbach's alpha = 0.7), internal consistency, criterion validity and reliability (concordance correlation coefficient intra‐rater = 0.99, 95% CI: 0.98–0.99; inter‐rater = 0.98, 95% CI: 0.96–0.99) were favourable. Conclusions Global intraocular inflammation can potentially be staged and scored objectively, continuously, consistently and in a valid manner through the combined processing of SS‐OCT scans.

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“… 15 Moreover, the advent of higher resolution OCT has paved the way for quantitative evaluation and monitoring of uveitis. 14 , 16 The objective quantification of uveitis by OCT enables reliable assessment of progression or regression of disease, with less reliance on child cooperation at the slit lamp.…”

Section: Overview Of Imaging Modalitiesmentioning

confidence: 99%

Multimodal imaging in pediatric uveitis

et al. 2021

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Pediatric uveitis accounts for up to 10% of all uveitis cases, so special attention must be paid to ensure early diagnosis as well as treatment and follow-up of these young patients in order to decrease the risk of possible ocular complications and consequently vision loss. Multimodal imaging has been an effective and important adjunct in the diagnoses and management of uveitis, especially in children. Reviewed here are the currently utilized modalities, advances, as well as their applications in juvenile idiopathic arthritis–associated uveitis, pars planitis, retinal vasculitis, tubulointerstitial nephritis and uveitis syndrome, Behçet disease, Blau syndrome, and Vogt–Koyanagi–Harada syndrome.

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Analysis of ocular inflammation in anterior chamber—involving uveitis using swept-source anterior segment OCT

Cited by 16 publications

References 19 publications

The feasibility of clinical evaluation for anterior uveitis through spectral‐domain optical coherence tomography in dogs

The feasibility of clinical evaluation for anterior uveitis through spectral‐domain optical coherence tomography in dogs

Swept‐source optical coherence tomography objective composite activity score for uveitis

Multimodal imaging in pediatric uveitis

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