The feasibility of clinical evaluation for anterior uveitis through spectral‐domain optical coherence tomography in dogs

Abstract

Objective: To evaluate the clinical application of spectral-domain optical coherence tomography (SD-OCT) for anterior uveitis in dogs. Animals and procedures:Client-owned dogs presenting with anterior uveitis and clinically healthy dogs were enrolled in this study. Included eyes were divided into 5 groups by flare grade and 3 groups by cell grade through slit-lamp biomicroscopy. Each eye was examined using SD-OCT following slit-lamp biomicroscopy. The ratio of aqueous signal intensity to air signal intensity, which is called the aqueous-to-air relative intensity (ARI) index, was used to evaluate the flare grade. Cell number, central corneal thickness (CCT), and the presence of keratic precipitates (KPs) were analyzed on SD-OCT. The OCT parameters, including ARI index, cell number, and CCT, were compared to the slit-lamp clinical flare and cell grade.Results: Thirty-six eyes with anterior uveitis and 27 healthy eyes were enrolled. The ARI index showed a significant correlation with clinical flare grade (r s = 0.811, p < .001). In multiple regression analysis, the ARI index and CCT showed a significant negative correlation (r = −0.258, p = .044). The number of cells on SD-OCT significantly increased with cell grade on slit-lamp biomicroscopy (r s = 0.653, p < .001). The clinical flare grade and CCT were significantly correlated in the partial correlation analysis after controlling for age (partial correlation coefficient = 0.471, p = .002). KPs were observed in 61% of the eyes with flare using SD-OCT (22/36 eyes).Conclusions: Spectral-domain optical coherence tomography could provide quantitative information, including the ARI index, cell counts, and CCT in dogs. SD-OCT is an auxiliary modality for slit-lamp biomicroscopy when evaluating anterior uveitis in dogs.

Alterações Oftálmicas Secundárias À Erliquiose Monocítica Canina

“…Embora seja uma ferramenta oftalmológica muito útil na visualização das estruturas oculares, a biomicroscopia com lâmpada de fenda pode ter algumas limitações em situações de opacidade severa das estruturas oculares (HEINRICH, 2014). Nesses casos, outros exames complementares, como a ultrassonografia ocular ou a tomografia de coerência óptica, podem ser utilizados para auxiliar no diagnóstico (JEONG et al, 2021).…”

A Pilot Study to Evaluate the Usefulness of Optical Coherence Tomography for Staging Iris Pigmented Lesions in Cats

“…A report comparing AS-OCT with UBM showed that while UBM offered better visualization of the posterior margin, AS-OCT provided better resolution of the anterior margin of the tumor than UBM [ 13 ]. In veterinary medicine, an increasing number of reports on the use of OCT for evaluating the anterior segment including the cornea, anterior chamber, and iridocorneal angle in dogs have been published [ 15 , 16 , 17 , 18 ]. However, there are no clinical reports focusing on the use of AS-OCT for examining iris lesions in cats.…”