Rhodomyrtosone B, a membrane-targeting anti-MRSA natural acylgphloroglucinol from Rhodomyrtus tomentosa

Zhao, Liyun; Liu, Hongxin; Wang, Lei; Xu, Zhifang; Tan, Haibo; Qiu, Shaofu

doi:10.1016/j.jep.2018.09.011

Cited by 23 publications

(23 citation statements)

References 29 publications

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“…The berries, leaves and stems of R. tomentosa are traditionally used to treat diarrhea, wound infections and traumatic hemorrhage (Ong and Nordiana, 1999;Li and Xing, 2016). The leaf ethanol extract exhibited MICs of 7.8-32 μg/mL against Gram-positive bacteria such as Bacillus cereus, S. aureus (including MRSA), Streptococcus mutans, S. agalactiae and Listeria monocytogenes (Phoem and Voravuthikunchai, 2012;Limsuwan and Voravuthikunchai, 2013;Odedina et al, 2015;Na-Phatthalung et al, 2017;Zhao et al, 2019). Rhodomyrtone 25, an acylphloroglucinol, is responsible for the antibacterial (bactericidal) activity against Gram-positive bacteria but is not active against Gram-negative bacteria (Limsuwan et al, 2011).…”

Section: Myrtaceaementioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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Background: Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s’ golden age of discovery. Plants produce a variety of bioactive secondary metabolites that could be used to fuel the future discovery pipeline. While many studies have focused on specific aspects of plants and plant natural products with antibacterial properties, a comprehensive review of the antibacterial potential of plants has never before been attempted.Objectives: This systematic review aims to evaluate reports on plants with significant antibacterial activities.Methods: Following the PRISMA model, we searched three electronic databases: Web of Science, PubMed and SciFinder by using specific keywords: “plant,” “antibacterial,” “inhibitory concentration.”Results: We identified a total of 6,083 articles published between 1946 and 2019 and then reviewed 66% of these (4,024) focusing on articles published between 2012 and 2019. A rigorous selection process was implemented using clear inclusion and exclusion criteria, yielding data on 958 plant species derived from 483 scientific articles. Antibacterial activity is found in 51 of 79 vascular plant orders throughout the phylogenetic tree. Most are reported within eudicots, with the bulk of species being asterids. Antibacterial activity is not prominent in monocotyledons. Phylogenetic distribution strongly supports the concept of chemical evolution across plant clades, especially in more derived eudicot families. The Lamiaceae, Fabaceae and Asteraceae were the most represented plant families, while Cinnamomum verum, Rosmarinus vulgaris and Thymus vulgaris were the most studied species. South Africa was the most represented site of plant collection. Crude extraction in methanol was the most represented type of extraction and leaves were the main plant tissue investigated. Finally, Staphylococcus aureus was the most targeted pathogenic bacteria in these studies. We closely examine 70 prominent medicinal plant species from the 15 families most studied in the literature.Conclusion: This review depicts the current state of knowledge regarding antibacterials from plants and provides powerful recommendations for future research directions.

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Section: Myrtaceaementioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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“…Scanning electron microscope results revealed the morphological changes in chelerythrine-treated bacteria, such as the damage of both cell wall and cell membrane and the destruction of the channels across the bacterial cell membranes, which allowed protein to leak out of the cell and suppressed protein biosynthesis. Zhao et al (2019) (Li et al, 2019).…”

Section: Effect On the Permeability Of Cell Membranementioning

confidence: 99%

Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria

Qiu

Hua

et al. 2020

Front. Microbiol.

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Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditional Chinese medicine (TCM). Here, we summarized the inhibitory mechanism of TCM herbs and their active ingredients on bacteria, discussed the regulatory mechanism of TCM on antibiotic-resistant bacteria, and revealed preclinical results of TCM herbs and their active components against antibiotic-resistant bacteria in mouse models. Those data suggest that TCM herbs and their effective constituents exhibit potential blockage ability on antibiotic-resistant bacteria, providing novel therapeutic ideas for reversing antibiotic resistance.

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“…Currently, many medicinal plants and their components have been used to treat infectious diseases (Wu et al, 2016, 2018), such as Coptis chinensis Franch. (Yu et al 2005), and Rhodomyrtus tomentosa (Zhao et al, 2019). Licorice, the root and rhizome of Glycyrrhiza spp., is widely used in prescriptions of traditional Chinese medicine, food, and cosmetics industry (Vaya et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus

Yang

Liu

et al. 2019

Front. Microbiol.

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Staphylococcus aureus is a bacterial pathogen that causes food poisoning, various infections, and sepsis. Effective strategies and new drugs are needed to control S. aureus associated infections due to the emergence and rapid dissemination of antibiotic resistance. In the present study, the antibacterial activity, potential mode of action, and applications of flavonoids from licorice were investigated. Here, we showed that glabrol, licochalcone A, licochalcone C, and licochalcone E displayed high efficiency against methicillin-resistant Staphylococcus aureus (MRSA). Glabrol, licochalcone A, licochalcone C, and licochalcone E exhibited low cytotoxicity without hemolytic activity based on safety evaluation. Glabrol displayed rapid bactericidal activity with low levels of resistance development in vitro. Meanwhile, glabrol rapidly increased bacterial membrane permeability and dissipated the proton move force. Furthermore, we found that peptidoglycan, phosphatidylglycerol, and cardiolipin inhibited the antibacterial activity of glabrol. Molecular docking showed that glabrol binds to phosphatidylglycerol and cardiolipin through the formation of hydrogen bonds. Lastly, glabrol showed antibacterial activity against MRSA in both in vivo and in vitro models. Altogether, these results suggest that glabrol is a promising lead compound for the design of membrane-active antibacterial agents against MRSA and can be used as a disinfectant candidate as well.

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Rhodomyrtosone B, a membrane-targeting anti-MRSA natural acylgphloroglucinol from Rhodomyrtus tomentosa

Cited by 23 publications

References 29 publications

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria

Antibacterial Effect and Mode of Action of Flavonoids From Licorice Against Methicillin-Resistant Staphylococcus aureus

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