Differential effects of β-glucan on oxidative stress, inflammation and copper transport in two intestinal regions of large yellow croaker Larimichthys crocea under acute copper stress

Zeng, Lin; Wang, Yonghong; Ai, Chunxiang; Zhang, Jianshe

doi:10.1016/j.ecoenv.2018.08.098

Cited by 25 publications

(15 citation statements)

References 67 publications

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“…In the current study, β-glucan supplementation did not affect fish growth performance over the course of the trial (8 weeks), independently from its source. However, it did show immunomodulatory effects and improved oxidative stress status in accordance with the findings reported in other studies [23,[44][45][46][47]. Dietary treatments appeared to modulate peripheral lymphocyte numbers.…”

Section: Discussionsupporting

confidence: 90%

“…BGs are reported to have antioxidant properties and modulate antioxidant enzymes activity as well as inhibiting lipid peroxidation in mammals [54]. In fish, BG injection increased SOD and CAT activities in the intestine [46] and blood erythrocytes [55], suggesting that BGs could improve anti-oxidative capacity. Accordingly, hepatic lipid peroxidation decreased in Phaeo37-and MG-fed animals at an early stage (2 weeks), while hepatic SOD showed a long-term (8 weeks) stimulation pattern, with the Phaeo37-fed group showing the highest activity.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, hepatic lipid peroxidation decreased in Phaeo37-and MG-fed animals at an early stage (2 weeks), while hepatic SOD showed a long-term (8 weeks) stimulation pattern, with the Phaeo37-fed group showing the highest activity. Zeng, et al [46] reported a correlation between higher mRNA transcription of nuclear factor erythroid 2-related factor 2 (Nrf2) gene and increased SOD and CAT genes transcription, which translated in higher enzyme activity in fish injected with a 0.1% BG solution. Nrf proteins, under oxidative conditions translocate to the nucleus where they bind to the antioxidant response element (ARE) [56].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported higher antioxidant enzyme activity and lower lipid peroxidation when fish are previously treated with BGs through different administration routes (i.e., i.p. injection; oral route) [46,55,58]. After a toxicological insult, pre-treated fish with barley-derived BG were able to prevent intestinal Cu-induced lipid peroxidation [46].…”

Section: Discussionmentioning

confidence: 99%

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Immune Status and Hepatic Antioxidant Capacity of Gilthead Seabream Sparus aurata Juveniles Fed Yeast and Microalga Derived β-glucans

et al. 2021

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This work aimed to evaluate the effects of dietary supplementation with β-glucans extracted from yeast (Saccharomyces cerevisiae) and microalga (Phaeodactylum tricornutum) on gene expression, oxidative stress biomarkers and plasma immune parameters in gilthead seabream (Sparus aurata) juveniles. A practical commercial diet was used as the control (CTRL), and three others based on CTRL were further supplemented with different β-glucan extracts. One was derived from S. cerevisiae (diet MG) and two different extracts of 21% and 37% P. tricornutum-derived β-glucans (defined as Phaeo21 and Phaeo37), to give a final 0.06% β-glucan dietary concentration. Quadruplicate groups of 95 gilthead seabream (initial body weight: 4.1 ± 0.1 g) were fed to satiation three times a day for 8 weeks in a pulse-feeding regimen, with experimental diets intercalated with the CTRL dietary treatment every 2 weeks. After 8 weeks of feeding, all groups showed equal growth performance and no changes were found in plasma innate immune status. Nonetheless, fish groups fed β-glucans supplemented diets showed an improved anti-oxidant status compared to those fed CTRL at both sampling points (i.e., 2 and 8 weeks). The intestinal gene expression analysis highlighted the immunomodulatory role of Phaeo37 diet after 8 weeks, inducing an immune tolerance effect in gilthead seabream intestine, and a general down-regulation of immune-related gene expression. In conclusion, the results suggest that the dietary pulse administration of a P. tricornutum 37% enriched-β-glucans extract might be used as a counter-measure in a context of gut inflammation, due to its immune-tolerant and anti-oxidative effects.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Immune Status and Hepatic Antioxidant Capacity of Gilthead Seabream Sparus aurata Juveniles Fed Yeast and Microalga Derived β-glucans

et al. 2021

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“…Moreover, (1 → 3)-β-D-glucan treatments profoundly enhanced the testis toxicity induced by bortezomib-dependent oxidative stress. These results are in agreement with a recent study showing that β-glucan induced the copper transport, oxidative stress, and inflammation were varied between the anterior and mid intestines under Copper stress on fish(Zeng, Wang, Ai, & Zhang, 2018).…”

supporting

confidence: 93%

(1 → 3)‐β‐ d ‐glucan enhances the toxicity induced by Bortezomib in rat testis

et al. 2020

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We aimed to determine the possible effects of the antioxidant agent (1 → 3)‐β‐D‐glucan on bortezomib‐induced rat testis damage. We used five groups of rats; control, (1 → 3)‐β‐D‐glucan (75 mg/kg), bortezomib group, bortezomib + (1 → 3)‐β‐D‐glucan groups (injection of (1 → 3)‐β‐D‐glucan after bortezomib and sacrificed at 48th or 72nd h). The effects of these substances were assessed by measuring the levels of the antioxidant enzymes and LPO, and by performing immunohistochemical analysis with NF‐κB. The histology of testis was evaluated using aniline blue staining. (1 → 3)‐β‐D‐glucan leads to significant reductions in the levels of antioxidant enzymes and increased levels of LPO in testes. Moreover, it increased the NF‐κB immunopositivity significantly in testis, especially in Bortezomib + (1 → 3)‐β‐D‐glucan group at 48th h. The histological changes were observed in the bortezomib and/or (1 → 3)‐β‐D‐glucan groups. Our results demonstrated that testis damage caused by the treatment with bortezomib was not eliminated by (1 → 3)‐β‐D‐glucan and shockingly it increased the damage. Practical applications The testis damage caused by the treatment with bortezomib was not eliminated by (1 → 3)‐β‐D‐glucan and as a result, β‐1,3‐(D)‐glucan enhanced the toxicity by leading a decrease in the levels of GSH, SOD, and CAT, thus caused an elevation in the immunoreactivity of NF‐κB and altered the histopathological changes by enhancing the toxic effects of bortezomib. The findings of the previous studies about the antioxidative activity of (1 → 3)‐β‐D‐glucan are controversial. So, it is necessary to consider the cytotoxicity of (1 → 3)‐β‐D‐glucan in testis tissue. Thus, more studies on testis tissue are necessary to confirm that (1 → 3)‐β‐D‐glucan is safe as an antioxidant.

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Toxicity of Copper in Epinephelus marginatus (Perciformes; Serranidae) After Ingestion of Contaminated Food

Francisco

Aride

Souza

et al. 2020

Bull Environ Contam Toxicol

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Differential effects of β-glucan on oxidative stress, inflammation and copper transport in two intestinal regions of large yellow croaker Larimichthys crocea under acute copper stress

Cited by 25 publications

References 67 publications

Immune Status and Hepatic Antioxidant Capacity of Gilthead Seabream Sparus aurata Juveniles Fed Yeast and Microalga Derived β-glucans

Immune Status and Hepatic Antioxidant Capacity of Gilthead Seabream Sparus aurata Juveniles Fed Yeast and Microalga Derived β-glucans

(1 → 3)‐β‐ d ‐glucan enhances the toxicity induced by Bortezomib in rat testis

Toxicity of Copper in Epinephelus marginatus (Perciformes; Serranidae) After Ingestion of Contaminated Food

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