Immune Status and Hepatic Antioxidant Capacity of Gilthead Seabream Sparus aurata Juveniles Fed Yeast and Microalga Derived β-glucans

Reis, Bruno; Gonçalves, Ana Teresa; Santos, Paulo; Sardinha, Manuel; Conceição, Luı́s E.C.; Serradeiro, Renata; Pérez‐Sánchez, Jaume; Calduch-Giner, Josep À.; Schmid‐Staiger, Ulrike; Frick, Konstantin; Dias, Jorge; Costas, Benjamín

doi:10.3390/md19120653

Cited by 22 publications

(19 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are found as components in plants, fungi, yeasts, and bacteria, among other microorganisms, playing a structural role or as an energy reservoir [ 1 ]. These molecules are known to have several interesting properties, such as anti-cancer activity [ 3 ], antiseptic effects [ 4 ], antioxidant properties [ 5 ], decreasing the risk of cardiovascular disease [ 6 ], and improving immunological responses in several animals [ 7 , 8 , 9 ]. This last observation has been reported in studies carried out on salmon and trout species, whereby supplementing fish diets with β-glucans improve its resistance to pathogens [ 10 , 11 ]…”

Section: Introductionmentioning

confidence: 99%

A Modeled High-Density Fed-Batch Culture Improves Biomass Growth and β-Glucans Accumulation in Microchloropsis salina

Ocaranza

Balic²,

Bruna³

et al. 2022

Plants

View full text Add to dashboard Cite

Algae and microalgae are used as a source of different biomolecules, such as lipids and carbohydrates. Among carbohydrates, polysaccharides, such as β-glucans, are important for their application as antioxidants, antisepsis, and immunomodulators. In the present work, the β-glucans production potential of Microchloropsis salina was assessed using two different culture conditions: a high-density batch and a modeled high-density fed-batch. From the biochemical parameters determined from these two cultures conditions, it was possible to establish that the modeled high-density fed-batch culture improves the biomass growth. It was possible to obtain a biomass productivity equal to 8.00 × 10−2 ± 2.00 × 10−3 g/(L × day), while the batch condition reached 5.13 × 10−2 ± 4.00 × 10−4 g/(L × day). The same phenomenon was observed when analyzing the β-glucans accumulation, reaching volumetric productivity equal to 5.96 × 10−3 ± 2.00 × 10−4 g of product/(L × day) against the 4.10 × 10−3 ± 2.00 × 10−4 g of product/(L × day) obtained in batch conditions. These data establish a baseline condition to optimize and significantly increase β-glucan productivity, as well as biomass, adding a new and productive source of this polymer, and integrating its use in potential applications in the human and animal nutraceutical industry.

show abstract

Section: Introductionmentioning

confidence: 99%

A Modeled High-Density Fed-Batch Culture Improves Biomass Growth and β-Glucans Accumulation in Microchloropsis salina

Ocaranza

Balic²,

Bruna³

et al. 2022

Plants

View full text Add to dashboard Cite

show abstract

“…They are already used in foods, medicine, and cosmetics [24] due to nutraceutical functions, such as antitumor, anti-inflammatory, antioxidant, anticoagulant, and immunostimulant effects [23,25]. Similar properties have already been reported for laminarin [26], Chrl [27,28], and Chrl from PT [29,30]. Due to the various ingredients of PT and their health-promoting properties, it is suspected to promote intestinal health.…”

Section: Introductionmentioning

confidence: 60%

“…A negative correlation was measured between the n-3 PUFA in the liver, which was increased by the PT diets, and pro-inflammatory IL-1β, suggesting an anti-inflammatory effect of PT, which is further supported by the reducing effect of the PT diets on the n-6:n-3 ratio. The Chrl-rich extract of PT (0.06%) has immunomodulatory effects in sea bream [30], which might be related to induction of intestinal TNF-α levels. The increase in TNF-α levels observed in our studies requires further investigation, and measurement inaccuracies must be prevented.…”

Section: Discussionmentioning

confidence: 99%

The Microalgae Phaeodactylum tricornutum Is Well Suited as a Food with Positive Effects on the Intestinal Microbiota and the Generation of SCFA: Results from a Pre-Clinical Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

Microalgae such as Phaeodactylum tricornutum (PT) are a sustainable source of nutrients, especially eicosapentaenoic acid (EPA), fucoxanthin (Fx), and chrysolaminarin (Chrl), the concentrations of which can vary depending on the culture conditions. We generated three types of diets containing either an EPA- and Fx-rich (EPA/Fx) or Chrl-rich microalgae (with 5, 15, or 25% added to the diet) or an isocaloric control diet (CD). These diets were evaluated over 14 days in young C57BL/6J mice for safety and bioavailability, short-chain fatty acid (SCFA) production, and microbiome analysis. Both microalgae diets increased body weight gain dose-dependently compared to the CD. Microalgae-derived EPA was well absorbed, resulting in increased liver and fat tissue levels and a decrease in the n-6:n-3 ratio in liver tissue. Both microalgae diets increased the production of selected SCFA and decreased the Firmicutes/Bacteriodota ratio, whereas the Chrl-rich diet led to an increase in Akkermansia. Doses of up to 4621 mg Chrl, 920 mg EPA, and 231 mg Fx per kg body weight daily were tolerated without adverse effects. This pre-clinical study shows that PT is suitable for mouse feed, with positive effects on microbiota composition and SCFA production, suggesting beneficial effects on gut health.

show abstract

“…The effects of β-glucans extracted from the microalga Phaeodactylum tricornutum have been recently evaluated following their application as food supplements for seabream Sparus aurata juveniles, a valuable fish species for European aquaculture [ 62 ]. P. tricornutum is a marine diatom that is rich in numerous health-beneficial compounds, including β-glucans [ 63 , 64 , 65 ].…”

Section: Marine Microorganisms As Source Of Immunomodulatory Compoundsmentioning

confidence: 99%

Recent Discoveries on Marine Organism Immunomodulatory Activities

2022

View full text Add to dashboard Cite

Marine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity and in the variety of chemical structures of marine natural products. Various studies have focused on marine organism compounds with potential pharmaceutical applications, for instance, as immunomodulators, to treat cancer and immune-mediated diseases. Modulation of the immune system is defined as any change in the immune response that can result in the induction, expression, amplification, or inhibition of any phase of the immune response. Studies very often focus on the effects of marine-derived compounds on macrophages, as well as lymphocytes, by analyzing the release of mediators (cytokines) by using the immunological assay enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and real-time PCR. The main sources are fungi, bacteria, microalgae, macroalgae, sponges, mollusks, corals, and fishes. This review is focused on the marine-derived molecules discovered in the last three years as potential immunomodulatory drugs.

show abstract

Immune Status and Hepatic Antioxidant Capacity of Gilthead Seabream Sparus aurata Juveniles Fed Yeast and Microalga Derived β-glucans

Cited by 22 publications

References 87 publications

A Modeled High-Density Fed-Batch Culture Improves Biomass Growth and β-Glucans Accumulation in Microchloropsis salina

A Modeled High-Density Fed-Batch Culture Improves Biomass Growth and β-Glucans Accumulation in Microchloropsis salina

The Microalgae Phaeodactylum tricornutum Is Well Suited as a Food with Positive Effects on the Intestinal Microbiota and the Generation of SCFA: Results from a Pre-Clinical Study

Recent Discoveries on Marine Organism Immunomodulatory Activities

Contact Info

Product

Resources

About