Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis

Sadatsuki, R.; Ishijima, Muneaki; Kaneko, Haruka; Liu, Lizu; Futami, I.; Hada, S.; Kinoshita, M.; Kubota, Mitsuaki; Aoki, Takako; Takazawa, Yuji; Ikeda, Hiroshi; Okada, Yasunori

doi:10.1007/s00774-018-0950-z

Cited by 10 publications

(14 citation statements)

References 44 publications

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“…Bone marrow lesions (sometimes called bone marrow edema) have been demonstrated to be present in individuals without [ 8 , 22 ] and with [ 23 ] clinical OA; to wax and wane with weight-bearing activity (e.g., in marathon runners [ 24 , 25 ]); and to be associated with incident knee pain in individuals at risk of OA [ 26 ], and with pain and disability for activities of daily living in patients with established OA [ 9 ]. Joint fluid overload correlates with symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…The search yielded 135 articles (Supplementary Appendix) of which 113 were excluded by title, abstract, or full-text review for the following reasons: study of a medical treatment, surgical study, or procedure (23), bone density or mechanical properties of bone or cartilage (19), specific patient or animal subgroup (12), posttraumatic osteoarthritis (6), or receptors, hormones, or biological markers (6); interventional study (14); test of imaging technique (7); histological or morphometric study (5); review article (14) or letter (1); non-English language (6). Twenty-two articles were eligible, of which 13 [6][7][8][9][10][11][12][13][14][15][16][17][18] were cited because they had the highest relevance to inform the proposed clinical model (Fig. 2).…”

Section: Literature Searchmentioning

confidence: 99%

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Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Gourlay

2020

Clin Rheumatol

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Because the pathophysiology of knee osteoarthritis is poorly understood, optimal evidence-based clinical management is uncertain. Sibling comparison studies can help inform a clinical model to guide preventive care. We compared the 8-year clinical outcomes in 2 sisters with a family history of osteoarthritis, normal BMI, and absence of knee pain at baseline. Both patients had Kellgren–Lawrence grade 1 in the affected knee at the time of twisting knee injuries leading to osteoarthritis diagnoses at age 50 (patient 1) and 51 (patient 2). Patient 1 developed a chronic right knee effusion, and progressed to Kellgren–Lawrence grade 3 bilaterally by the time she had a right total knee replacement at age 58. Patient 2 had subchondral fractures of the right knee with transient effusion, which healed after 1 year of partial weight-bearing with crutches and subsequent daily use of knee sleeves. Patient 2 had Kellgren–Lawrence grade 0 bilaterally upon surveillance imaging at age 58. The terms “osteoarthritis and knee and diagnostic imaging and subchondral bone and pathophysiology” were searched in the PubMed database to identify original research articles to inform a clinical model consistent with the patients’ outcomes. A fluid model of osteoarthritis was the best explanatory model for the discordant clinical trajectories of the age-matched siblings. Patient recommendations are presented based on these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Gourlay

2020

Clin Rheumatol

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“…Diagnostic criteria for KOA KOA was diagnosed according to the "Guidelines for the Diagnosis and Treatment of Osteoarthritis (2007 edition)" that were revised and issued by the Chinese Orthopaedic Association [5]: 1) repeated knee joint pain within the past month; 2) X-ray (standing position or weight-bearing position) exhibiting reduced joint space, osteosclerosis, or cystic degeneration of subchondral bone, and osteophyte formation at joint margin; 3) clear and sticky synovial uid (in at least two measurements) with WBC < 2000/mL; 4) middleaged or elderly patients (≥ 40 years old); 5) morning stiffness ≤ 3 min; and 6) bony crepitus during activities. The patients were diagnosed with KOA if they met the items of 1 + 2, 1 + 3 + 5 + 6, or 1 + 4 + 5 + 6.…”

Section: Patientsmentioning

confidence: 99%

“…These long-term injuries could induce articular cartilage degeneration [3]. KOA mainly occurs in middle-aged or elderly individuals, and its progression may result in severe complications such as pain and loss of mobility of the knee joint [4,5].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Deep Hyperthermia Combined with Dynamic Traction in the Treatment of Knee Osteoarthritis

Wang¹,

Liu²,

Zhang³

et al. 2021

Preprint

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Background: Different treatments with varying clinical efficacies have been applied to treat knee osteoarthritis (KOA). This study observes the effectiveness of deep hyperthermia combined with dynamic traction in KOA treatment. Methods: Deep hyperthermia and dynamic traction was administered to 60 patients with KOA. The pretreatment and 20- and 40-day post-treatment visual analog scale (VAS) and Lysholm score, knee joint cavity effusion, synovium thickness, and synovial blood flow signal (by high-frequency ultrasound) of the patients were recorded. The pretreatment and 20- and 40-day post-treatment Lysholm scores were 47.17 ± 5.07, 63.22 ± 3.44, and 81.98 ± 3.30 (P < 0.001), respectively. Results: The pretreatment and 20- and 40-day post-treatment VAS scores were 5.67 ± 0.91, 2.92 ± 0.81, and 0.60 ± 0.72 (P < 0.001), respectively. The pretreatment and 20- and 40-day post-treatment articular effusion was 5.41 ± 0.46 mm, 4.34 ± 0.34 mm, and 2.32 ± 0.32 mm (P < 0.001), respectively. The pretreatment and 20- and 40-day post-treatment synovial thickness was 3.44 ± 0.31 mm, 2.79 ± 0.15 mm, and 2.32 ± 0.32 mm (P < 0.001), respectively. The pretreatment and 20- and 40-day post-treatment grades of synovial blood flow signal exhibited a significant difference (P < 0.001). Conclusion: Deep hyperthermia combined with dynamic traction can significantly improve the clinical symptoms and pain degree in KOA, reduce joint cavity effusion, synovium thickness, and internal blood flow, and the effect improves with time. The changes in soft tissues observed by high-frequency ultrasound are reliable and consistent with clinical signs.

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“…Morphological changes in knee OA were semiquantitatively evaluated according to the Whole Organ MRI Score 82. Medial meniscus extrusion was also evaluated, we previously described83–86…”

Section: Measurementsmentioning

confidence: 99%

Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study

et al. 2019

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PurposeThe proportion of elderly individuals (age ≥65 years) in Japan reached 27.7% in 2017, the highest in the world. A serious social problem in a super-aged society is the rise in the number of elderly people who need long-term care (LTC), which is mainly due to cerebrovascular disease, dementia, age-related frailty, falls and fractures, and joint disease. We hypothesised that decreased muscle mass, muscle strength and insulin sensitivity are the common risk factors for these diseases related to needing LTC. We developed a prospective cohort study of elderly subjects in an urban community to test this hypothesis. The primary objective is to prospectively investigate associations between muscle mass, muscle strength, and insulin sensitivity and incidence of main disease and risk factors of needing LTC. The primary outcomes are the incidence of cerebrovascular disease and cognitive decline.ParticipantsParticipants were 1629 people aged 65–84 years living in 13 communities in an urban area (Bunkyo-ku, Tokyo, Japan). Average age was 73.1±5.4 years.Findings to dateWe obtained baseline data on cognitive function, cerebral small vessel disease (SVD) determined by brain MRI, body composition, bone mineral density, arteriosclerosis, physical function, muscle mass, muscle strength and insulin sensitivity. Mild cognitive impairment and dementia were observed in 18.1% and 3.3% of participants, respectively. The prevalence of cerebral SVD was 24.8%. These characteristics are similar to those previously reported in elderly Japanese subjects.Future plansWe will ask participants about their health status, including incidence of cerebrovascular disease, falls, fractures and other diseases every year by mail. We plan to re-evaluate cognitive function, brain MRI parameters and other parameters at 5 and 10 years after the baseline evaluation. We will evaluate whether low muscle function (muscle mass, muscle strength or insulin sensitivity) is a risk factor for cognitive decline or cerebrovascular disease.

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Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis

Cited by 10 publications

References 44 publications

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Comparison of 8-year knee osteoarthritis progression in 2 siblings: a case-based review

Effectiveness of Deep Hyperthermia Combined with Dynamic Traction in the Treatment of Knee Osteoarthritis

Skeletal muscle function and need for long-term care of urban elderly people in Japan (the Bunkyo Health Study): a prospective cohort study

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